Anderans underwhelming?

[Desmond84]

If they can cultivate the cells from the 1st 1cm/2 strip, why would they need another 1cm/2 strip? Why not just use the same original batch and inject again? Also, why not go for repeat treatments if yield is low? So lets say we get 30% regrowth from the first round of injections another 15% from a second rate 3 months later? (obviously im guessing and making up numbers).

Why couldnt further injections be done with Aderans?

It's because we've only been able to maintain trichogenicity of DP cells (hair inducing potential) for about 6-8 weeks. After that they are useless!

Btw, one thing we don't know yet is how far apart would the injections have to be distance wise? Will we need 100s of injections like Histogen or will 20 or so be sufficient?

[Desmond84]

Desmond84, What if Histogen success and Aderans fails? Will it be a problem to us? I think they are having almost similar roles? Just wondering!!!

I think in that case we'll definitely get to stay above baseline + hopefully 20-30% regrowth for about 3-5 years!

But I have a feeling because it doesn't address the DHT issue, it's efficacy will start to fade as MPB progresses just like Minoxidil.

Also, one thing that has surprised me about Histogen is their study design! Generally, in Phase 1/2 studies your main focus is safety, so your aim is to find the maximum tolerated dose. Hence, you would naturally start with 8 injections then 20, 30, 50, 100 etc till you find patients either complaining of side effects or the entire treatment area is covered... But they just stuck to 8 injections in a small area in all 54 trial patients!

Let's hope their next study design is a bit more thought-out or FDA will never allow them to exceed 8-10 injections per session!

[hellouser]

I think in that case we'll definitely get to stay above baseline + hopefully 20-30% regrowth for about 3-5 years!

But I have a feeling because it doesn't address the DHT issue, it's efficacy will start to fade as MPB progresses just like Minoxidil.

Also, one thing that has surprised me about Histogen is their study design! Generally, in Phase 1/2 studies your main focus is safety, so your aim is to find the maximum tolerated dose. Hence, you would naturally start with 8 injections then 20, 30, 50, 100 etc till you find patients either complaining of side effects or the entire treatment area is covered... But they just stuck to 8 injections in a small area in all 54 trial patients!

Let's hope their next study design is a bit more thought-out or FDA will never allow them to exceed 8-10 injections per session!

The DHT issue *really* bothers me. I hope Aderans treatment will permanently halt hair loss, that would be HUGE. Everyguy that starts to recede would then go for a treatment with Aderans and they'd hopefully be set for life.

If Aderans does NOT prove to do this, then I guess its RU/CB for me until the next best thing....

DAMN YOU DR. LAUSTER! Guy has been sitting on the holy grail for 2+ years and we've heard nothing since!

[baldozer]

The DHT issue *really* bothers me. I hope Aderans treatment will permanently halt hair loss, that would be HUGE. Everyguy that starts to recede would then go for a treatment with Aderans and they'd hopefully be set for life.

If Aderans does NOT prove to do this, then I guess its RU/CB for me until the next best thing....

DAMN YOU DR. LAUSTER! Guy has been sitting on the holy grail for 2+ years and we've heard nothing since!

Does RU work differently than propecia. Aren't both of them 5 alpha reductase inhibitors or does RU work differently?

[hellouser]

Does RU work differently than propecia. Aren't both of them 5 alpha reductase inhibitors or does RU work differently?

I'm not entirely sure, but RU is supposed to be as effective if not more effective than Finasteride. Its going to completely depend on the vehicle, coverage and dosage. According to this article; http://www.ncbi.nlm.nih.gov/pubmed/9449168

RU is a blocker.

Considering CB is supposed to be 2-4X as effective as FIN, this should be prove to be quite the next step in fighting hair loss.... and NO SIDE EFFECTS. I'll be combining Minoxidil with RU and applying both mixed together during the day and an application of CB at night. We'll see where it gets me.

[garethbale]

DAMN YOU DR. LAUSTER! Guy has been sitting on the holy grail for 2+ years and we've heard nothing since!

What's Dr Lauster done that's so amazing?

Why does everyone keep saying he has a cure...

[hellouser]

What's Dr Lauster done that's so amazing?

Why does everyone keep saying he has a cure...

He cultured entire hair follicles.... and grown hair with them. That right there is the holy grail.

Watch this video:

https://www.youtube.com/watch?v=iAS_k1IrJpA

[LMS]

You're gonna be using RU and CB at the same time?

Seems like it might be tough to judge the efficacy of CB that way. What vehicle are you using?

[garethbale]

He cultured entire hair follicles.... and grown hair with them. That right there is the holy grail.

Watch this video:

https://www.youtube.com/watch?v=iAS_k1IrJpA

Yeah I have seen that video, but I take all that stuff with a pinch of salt...

[UK Boy]

I really hope Aderans can immunitise follicles, it's the only way they're gonna have a worthwhile product but they've never addressed the topic in presentations, they've always focused on regrowth not maintenence. I supposed if it's compoundable it'll also be more promising but again this is all only relevant if you're one of the lucky 60%. The problem with repeat sessions is that as it stands they've not mentioned cell banking, if they don't find some way to keep your cells 'on file' then you're gonna have to give up a cm squared of scalp each time, they'll probably charge you extra for cell banking too.

Histogen's next trial will deal with more injections etc. Dr. Ziering and the other doctor in Asia who are both doing their own independant trials of HSC have been trying different numbers of injections and have seen no negative effects so far.

Desmond I have no issue with most of what you say but I think it's pointless to speculate how long these treatments will work for. You said that Aderans could maintain for 10 years and Histogen could for 3-5 but that's based on nothing other than you comparing them to Minoxidil and Finasteride.

[FearTheLoss]

To be honest...we know practically nothing about Aderans..it's all speculation really. It would be nice if they could give us a ****ing update now..

[UK_]

What's Dr Lauster done that's so amazing?

Why does everyone keep saying he has a cure...

Dr Lauster created a fully functional hair follicle in a Petri dish - sebaceous glands and all.

[hellouser]

Dr Lauster created a fully functional hair follicle in a Petri dish - sebaceous glands and all.

If that aint the holy grail, I don't know what is.

[FearTheLoss]

and now we don't even know if he has continued research...depressing

[stayhopeful]

This is really, really lame guys. I think we should honestly all stay off this forum UNTIL there is some news release... I mean, it is nice to have support.. but literally, if you really think about it, every little thing we talk about is pure speculation. Let's all just STAY HOPEFUL and keep cool until the next news release--hopefully in the next couple of months from Anderans & Histogen. Anything else is just noise. Good luck to you all, 2013 is the year that we will learn what the real outlook will be for companies like Anderans and Histogen (i.e. phase II results and whether phase III initiates). Until then, I am going to try to limit my time on the forum as much as possible, and focus on stuff like going to the gym and studying--stuff that is contributory to pulling bitches. I'll be back here the second we get a news release, and hopefully at that time we will all be celebrating on the forum!