S-equol again

[burtandernie]

The problem with inhibiting 5 alpha reductase is that the enzyme is responsible for producing neurosteroids that are involved in sex drive, mood, and believe it or not tear formation. 5 alpha reductase inhibitors decrease tear formation leading to dry eye, and this is well documented.

Yeah actually I guess that is true. That is one of the big things that has kind of made me very hesitant to ever try finasteride myself over the years. The 5 ar 3 enzyme discovered after fin supposedly only stopped the 5-ar 2 is a little nerve racking when you consider how little anyone knows about the brain like neurosteroids. I mean anything going wrong there will never be fixable because no one has any idea how it works.
Yes for the last 25 years we have been wishing for a safer alternative to fin to just hair on our heads now yet alone regrowing anything. Still waiting.

[nobs]

It would be nice to see something like this that is affordable and can accomplish the same as propecia for just maintaining. If this worked though why would it not have sides just like propecia? This way or the enzyme the end result is just lower DHT

The problem with inhibiting 5 alpha reductase is that the enzyme is responsible for producing neurosteroids that are involved in sex drive, mood, and believe it or not tear formation. 5 alpha reductase inhibitors decrease tear formation leading to dry eye, and this is well documented.

[burtandernie]

It would be nice to see something like this that is affordable and can accomplish the same as propecia for just maintaining. If this worked though why would it not have sides just like propecia? This way or the enzyme the end result is just lower DHT

[Swooping]

Anyone know why NatureMade has spent years studying s-equol instead of releasing a damn product already? It's not like they can patent the molecule since it is naturally occurring.

You want that specific product you buy from Otsuka.. Look at their site;

Not everyone can produce S-equol after eating soy. Therefore, Pharmavite LLC, a subsidiary of Otsuka Pharmaceutical Co., Ltd., developed a rigorous clinical trials program to study a nutritional supplement containing S-equol to help manage menopausal symptoms. Additionally, researchers are studying S-equol for other potential health benefits.

supplement," said coauthor Belinda H. Jenks, Ph.D., director of Scientific Affairs & Nutrition Education at Pharmavite LLC, the makers of Nature MadeŽ vitamins and minerals and a subsidiary of Otsuka Pharmaceutical Co., Ltd., which supported the study.

[nobs]

It seems to me that we are going to have a new maintance drug. If the price will be low, Fin or Dut will not be necessary anymore.

Anyone know why NatureMade has spent years studying s-equol instead of releasing a damn product already? It's not like they can patent the molecule since it is naturally occurring.

[kuba197]

It seems to me that we are going to have a new maintance drug. If the price will be low, Fin or Dut will not be necessary anymore.

[kuba197]

http://www.asm.org/index.php/journal-press-releases/93952-recombinant-bacterium-boosts-production-of-compound-that-can-relieve-menopause-symptoms

[nobs]

This is the right one ; https://www.otsuka.co.jp/en/product/equelle/

http://equelle.jp

You can buy it on e-bay.

Looks legit, Otsuka is a very reputable pharma company. It is on the expensive side, but I wouldn't mind giving it a try if it means just dumping it into a bottle of minoxidil and posting before and after pics.

[Swooping]

I was reading that nature's sunshine's product doesn't really specify whether its r or s equal, and reps for the company havent answered that question upon request. Naturemade, probably the biggest supplement company, was talking about releasing an s equol product some 4 years ago but there hasnt been any updates recently.

This is the right one ; https://www.otsuka.co.jp/en/product/equelle/

http://equelle.jp

You can buy it on e-bay.

[nobs]

I was reading that nature's sunshine's product doesn't really specify whether its r or s equal, and reps for the company havent answered that question upon request. Naturemade, probably the biggest supplement company, was talking about releasing an s equol product some 4 years ago but there hasnt been any updates recently.

[Pray The Bald Away]

Is there any evidence that it works topically? I'd like to know more about this product if you have more info. I don't think getting quantity of s equol would be terribly difficult since it is a naturally occurring substance and not a licensed chemical.

https://www.google.com/search?q=s+eq...obile&ie=UTF-8 There's a lot of good info in this patent by Brigham Young University. There are more sources but this is a good place to start.

[Pray The Bald Away]

I took a 5hitload of it orally, but nothing happened, like 2 grams daily for 6 months...
but I got it from China, who knows was it pure and at what level.

Orally is gonna require enormous doses and even then it may metabolize too quickly. Topically is definitely the way to go.

[bananana]

I took a 5hitload of it orally, but nothing happened, like 2 grams daily for 6 months...
but I got it from China, who knows was it pure and at what level.

[nobs]

I'm not sure how good the penetration will be but you need to apply it daily because Equol doesn't attack the source. 5ar2 won't need to regenerate DHT levels so there will be a constant stream towards the scalp. If you decide to wait, there will be a product coming out in 2017 that uses cationic liposomal penetration to deliver S-Equol. This will likely be better than a standard ethanol solution. In fact, I'm not sure where you could reliably find S-Equol. Do you have a supplier?

Is there any evidence that it works topically? I'd like to know more about this product if you have more info. I don't think getting quantity of s equol would be terribly difficult since it is a naturally occurring substance and not a licensed chemical.

[Pray The Bald Away]

What's a good vehicle for s-equol? Standard ethanol/pg?

I'm not sure how good the penetration will be but you need to apply it daily because Equol doesn't attack the source. 5ar2 won't need to regenerate DHT levels so there will be a constant stream towards the scalp. If you decide to wait, there will be a product coming out in 2017 that uses cationic liposomal penetration to deliver S-Equol. This will likely be better than a standard ethanol solution. In fact, I'm not sure where you could reliably find S-Equol. Do you have a supplier?