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This is one product I have been dying to try and add to my regime, I have been constantly researching and before Dr Klein passed away I think he was going to do trials on topical Melatonin.
Anyways good news after several emails begging Susan to formulate this for the hairloss community she was convinced by the studies to add his on her wesbite for us guys
.
We now have an option to BUY topical Melatonin, so for anyone interested here are the details I will deffinatly be ordering this next month when my funds are better.
Studies;
http://www.pubfacts.com/detail/23766...netic-alopecia.
Int J Trichology. 2012 Oct;4(4):236-45. doi: 10.4103/0974-7753.111199.
Topical melatonin for treatment of androgenetic alopecia.
Fischer TW, Trüeb RM, Hänggi G, Innocenti M, Elsner P.
Source
Department for Dermatology, Allergology and Venereology, University of Lübeck, Lübeck, Germany.
Abstract
BACKGROUND:
In the search for alternative agents to oral finasteride and topical minoxidil for the treatment of androgenetic alopecia (AGA), melatonin, a potent antioxidant and growth modulator, was identified as a promising candidate based on in vitro and in vivo studies.
MATERIALS AND METHODS:
One pharmacodynamic study on topical application of melatonin and four clinical pre-post studies were performed in patients with androgenetic alopecia or general hair loss and evaluated by standardised questionnaires, TrichoScan, 60-second hair count test and hair pull test.
RESULTS:
FIVE CLINICAL STUDIES SHOWED POSITIVE EFFECTS OF A TOPICAL MELATONIN SOLUTION IN THE TREATMENT OF AGA IN MEN AND WOMEN WHILE SHOWING GOOD TOLERABILITY: (1) Pharmacodynamics under once-daily topical application in the evening showed no significant influence on endogenous serum melatonin levels. (2) An observational study involving 30 men and women showed a significant reduction in the degree of severity of alopecia after 30 and 90 days (P < 0.001) based on questionnaires completed by investigators and patients. (3) Using a digital software-supported epiluminescence technique (TrichoScan) in 35 men with AGA, after 3 and 6 months in 54.8% to 58.1% of the patients a significant increase of hair density of 29% and 41%, respectively was measured (M0: 123/cm(2); M3: 159/cm(2); M6: 173/cm(2) (P < 0,001). (4) In 60 men and women with hair loss, a significant reduction in hair loss was observed in women, while hair loss in men remained constant (P < 0.001). (5) In a large, 3-month, multi-center study with more than 1800 volunteers at 200 centers, the percentage of patients with a 2- to 3-fold positive hair-pull test decreased from 61.6% to 7.8%, while the percentage of patients with a negative hair-pull test increased from 12.2.% to 61.5% (P < 0.001). In addition, a decrease in seborrhea and seborrheic dermatitis of the scalp was observed.
CONCLUSIONS:
Since safety and tolerability in all of the studies was good, the topical application of a cosmetic melatonin solution can be considered as a treatment option in androgenetic alopecia.
Anyways good news after several emails begging Susan to formulate this for the hairloss community she was convinced by the studies to add his on her wesbite for us guys
.We now have an option to BUY topical Melatonin, so for anyone interested here are the details I will deffinatly be ordering this next month when my funds are better
.
Studies;
http://www.pubfacts.com/detail/23766...netic-alopecia.
Int J Trichology. 2012 Oct;4(4):236-45. doi: 10.4103/0974-7753.111199.
Topical melatonin for treatment of androgenetic alopecia.
Fischer TW, Trüeb RM, Hänggi G, Innocenti M, Elsner P.
Source
Department for Dermatology, Allergology and Venereology, University of Lübeck, Lübeck, Germany.
Abstract
BACKGROUND:
In the search for alternative agents to oral finasteride and topical minoxidil for the treatment of androgenetic alopecia (AGA), melatonin, a potent antioxidant and growth modulator, was identified as a promising candidate based on in vitro and in vivo studies.
MATERIALS AND METHODS:
One pharmacodynamic study on topical application of melatonin and four clinical pre-post studies were performed in patients with androgenetic alopecia or general hair loss and evaluated by standardised questionnaires, TrichoScan, 60-second hair count test and hair pull test.
RESULTS:
FIVE CLINICAL STUDIES SHOWED POSITIVE EFFECTS OF A TOPICAL MELATONIN SOLUTION IN THE TREATMENT OF AGA IN MEN AND WOMEN WHILE SHOWING GOOD TOLERABILITY: (1) Pharmacodynamics under once-daily topical application in the evening showed no significant influence on endogenous serum melatonin levels. (2) An observational study involving 30 men and women showed a significant reduction in the degree of severity of alopecia after 30 and 90 days (P < 0.001) based on questionnaires completed by investigators and patients. (3) Using a digital software-supported epiluminescence technique (TrichoScan) in 35 men with AGA, after 3 and 6 months in 54.8% to 58.1% of the patients a significant increase of hair density of 29% and 41%, respectively was measured (M0: 123/cm(2); M3: 159/cm(2); M6: 173/cm(2) (P < 0,001). (4) In 60 men and women with hair loss, a significant reduction in hair loss was observed in women, while hair loss in men remained constant (P < 0.001). (5) In a large, 3-month, multi-center study with more than 1800 volunteers at 200 centers, the percentage of patients with a 2- to 3-fold positive hair-pull test decreased from 61.6% to 7.8%, while the percentage of patients with a negative hair-pull test increased from 12.2.% to 61.5% (P < 0.001). In addition, a decrease in seborrhea and seborrheic dermatitis of the scalp was observed.
CONCLUSIONS:
Since safety and tolerability in all of the studies was good, the topical application of a cosmetic melatonin solution can be considered as a treatment option in androgenetic alopecia.
cheers
.
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