Jup good especially in combination with minoxidil (preferably mixed into it or applied directly after eachother. Def boosted my regrowth!
Retin-a works supposedly (even more so when combined with minoxidil);
- Increases ERK/AKT pathways.
- Increase bcl2/Bax
- Decrease P53 and downstream of it P21
(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693596/)
Here some more studies about retin-a def showing remarkable increased hair growth icm minoxidil (or stand-alone) ;
Ferry JJ, et al. Influence of tretinoin on the percutaneous absorbtion of minoxidil from an aqueous topical solution.Clin Pharmacol Ther (1990) 47:439-46.
Gazzano GS, et al. Topical tretinoin for hair growth promotion. J Am Acad Dermatol (1986) 15:880-883.
Shin HS, et al. Efficacy of 5% minoxidil versus combined 5% minoxidil and 0.01% tretinoin for male pattern hair loss:a randomized, double-blind, comparative clinical trial. Am J Clin Dermatol. 2007;8(5):285-90.
vi
Lewenberg A. Treatment of alopecia with a minoxidil-tretinoin combination. Adv Ther. (1991) 8:190-198.
Kligman AM, et al. Topical tretinoin for photoaged skin. J Am Acad Dermatol. 1986 Oct;15(4 Pt 2):836-59.
Now hydrocortisone has obviously anti-inflammatory actions.. and what is even way more interesting it upregulates sulfotransferase (this is the enzyme that is responsible for minoxidil effectiveness. Thats why some people go easily from nw4 to nw1 or 2 and some don't react at all). There is research going into this now. They are trying to find agents to upregulate sulfotransferase so more people can "hyper" respond to minoxidil.
So are they worth it stand-alone? Yes, but even more so in combination with minoxidil. It is basically my regimen for including RU and im heading to nw 1.5 where as i was NW4 almost. Good luck.
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