Enterolactone reduces DHT - Bald Truth Talk - Hair Loss, Hair Transplant and Hair Restoration Community

LF365

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Join Date: Oct 2009

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Enterolactone reduces DHT

10-25-2009, 12:28 AM

It has been know for some time that enterolactone is a plant lignan that has demonstrated inhibition of 5 alpha-reductase. These can be found in flax seeds and in supplement form.

Effects of dietary flaxseed lignan extract on symptoms of benign prostatic hyperplasia - PubMed

http://www.ncbi.nlm.nih.gov/pubmed/18358071

A flaxseed lignan extract containing 33% secoisolariciresinol diglucoside (SDG) was evaluated for its ability to alleviate lower urinary tract symptoms (LUTS) in 87 subjects with benign prostatic hyperplasia (BPH). A randomized, double-blind, placebo-controlled clinical trial with repeated measureme …

Inhibition of 5 alpha-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids - PubMed

http://www.ncbi.nlm.nih.gov/pubmed/7490559

Isoflavonoids and lignans, constituents of many plant foods, have been proposed as protective agents in those populations with a low incidence of hormone-dependent cancers. They may act by their inhibition of the metabolism of growth-promoting steroid hormones. This report describes the inhibition o …

Lignans interfering with 5 alpha-dihydrotestosterone binding to human sex hormone-binding globulin - PubMed

http://www.ncbi.nlm.nih.gov/pubmed/9461660

The natural lignans (-)-3,4-divanillyltetrahydrofuran (1), (-)-matairesinol (2), (-)-secoisolariciresinol (3), (+/-)-enterolactone (4), (+/-)-enterodiol (5), and nordihydroguaiaretic acid (NDGA) (6) reduce the binding of 3H-labeled 5 alpha-dihydrotestosterone (DHT) to human sex hormone-binding globu …

A more recent study has found that higher enterolactone levels, found lower risk of colon cancer among women and higher risk of rectal cancer among men.

Plasma enterolactone and risk of colon and rectal cancer in a case-cohort study of Danish men and women - PubMed

http://www.ncbi.nlm.nih.gov/pubmed/19844797

This case-cohort study examined the association between plasma enterolactone concentration and incidence of colon and rectal cancer in the Diet, Cancer and Health cohort, which enrolled 57,053 participants aged 50-64. Information about diet and lifestyle was obtained by questionnaire, and data on pr …
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