Antiandrogen kamikaze thread

[25 going on 65]

hmm tru man

u can order RU premade from anagen though which helps with convenience, and i have definitely seen people with long hair using it. You just part the hair in 6 different places and apply through out

you seem commited to trying spiro tho so good luck hopefully no sides

Thanks man. I still have not taken any, hate to admit it but I am nervous.
I did consider premixed RU but from what I have read it is quite a bit less effective than mixing fresh batches. Any opinion on this?

[Dan26]

Thanks man. I still have not taken any, hate to admit it but I am nervous.
I did consider premixed RU but from what I have read it is quite a bit less effective than mixing fresh batches. Any opinion on this?

Theres a thread on it I think lilpauly started it. Kane tested the stability/degradation of RU for 60 days or somthin I cant remember exactly, and there didn't seem to be any problem.

Are you shedding much these days? Many RU users can tell really quickly if it is working, I think in your case it is worth the gamble to order one premade mix and give it a shot. If it doesn't work then at least you can say you've tried.

RU personally did nothing for me as did fin, dut is my last shot at an AA. I THINK part of the reason RU didn't do much for me is because my DHT levels are still out of control. Id prob give it another try once dut lowers them.

[25 going on 65]

It does seem like I am shedding a good amount. Some days not so much, other days definitely. I know nothing about Anagen....are they supposed to be legitimate?

[Dan26]

It does seem like I am shedding a good amount. Some days not so much, other days definitely. I know nothing about Anagen....are they supposed to be legitimate?

Ya man they are legit Anagen is just Kanes Europe office because some European countries customs are real tough on stuff from China

[lilpauly]

It does seem like I am shedding a good amount. Some days not so much, other days definitely. I know nothing about Anagen....are they supposed to be legitimate?

Yes they are legit . U must attack hairloss from all angles . Dut , Minox and niz. Ru is the best experimental . Is it better then fin? Nope . It's good for targeting g areas and it works for lots and lots of people . In my honest option we gotta work on better vehicles . Ethanol sucks and pg f'n sucks

[25 going on 65]

Yes they are legit . U must attack hairloss from all angles . Dut , Minox and niz. Ru is the best experimental . Is it better then fin? Nope . It's good for targeting g areas and it works for lots and lots of people . In my honest option we gotta work on better vehicles . Ethanol sucks and pg f'n sucks

KB solution is the best vehicle for RU then?
Also do you still use fin+dut at the same time?

[Bjimmy]

Hello, TC. I've been alternating oral spironolactone (100-300 mg) and cyproterone acetate (50-200 mg) for just over a year now; I'll answer the questions in the relevant section of your OP as best I can.

If yes, how did it go for your hair?

Wonderfully. I went from a NW 3.5 with thinning in a NW 5A pattern to a very decent NW 2 in an exceedingly short period of time.

How were the sides?

On spironolactone, the sides were very mild... slight loss of sex drive and and decreased facial oiliness, in addition to the obvious diuretic side effect. The androgen-related sides were essentially unnoticeable up to 300 mg, although from what I gather, I am an aberration in that regard. The cyproterone acetate was different; at the highest doses, it all but killed my sex drive, and would often leave me in a state of lethargy. I would intermittently get random aches throughout my body. Facial oiliness and scalp itch were completely nonexistent. My body hair thinned out on both spironolactone and cyproterone acetate, although I would consider that a positive. Facial hair growth seemed to be inhibited. Oh, and spironolactone gave me VERY vivid dreams; as strange as that sounds, a few other guys on spiro reported the same thing over at another hairloss forum. No facial feminisation or (perceptible) muscle loss whatsoever.

Another thing that concerns me, it seems like this drug has not been studied much for andro alopecia in men. I would be more scared of it not working than the sides tbh

It was very, very efficacious for me, especially in light of the fact that my hair had previously actually marginally worsened after a year on finasteride.

[whatsgoingon]

Hello, TC. I've been alternating oral spironolactone (100-300 mg) and cyproterone acetate (50-200 mg) for just over a year now; I'll answer the questions in the relevant section of your OP as best I can.

If yes, how did it go for your hair?

Wonderfully. I went from a NW 3.5 with thinning in a NW 5A pattern to a very decent NW 2 in an exceedingly short period of time.

How were the sides?

On spironolactone, the sides were very mild... slight loss of sex drive and and decreased facial oiliness, in addition to the obvious diuretic side effect. The androgen-related sides were essentially unnoticeable up to 300 mg, although from what I gather, I am an aberration in that regard. The cyproterone acetate was different; at the highest doses, it all but killed my sex drive, and would often leave me in a state of lethargy. I would intermittently get random aches throughout my body. Facial oiliness and scalp itch were completely nonexistent. My body hair thinned out on both spironolactone and cyproterone acetate, although I would consider that a positive. Facial hair growth seemed to be inhibited. Oh, and spironolactone gave me VERY vivid dreams; as strange as that sounds, a few other guys on spiro reported the same thing over at another hairloss forum. No facial feminisation or (perceptible) muscle loss whatsoever.

Another thing that concerns me, it seems like this drug has not been studied much for andro alopecia in men. I would be more scared of it not working than the sides tbh

It was very, very efficacious for me, especially in light of the fact that my hair had previously actually marginally worsened after a year on finasteride.

why are you alternating between two drugs? And can you go into more detail on the regime and time period?

[25 going on 65]

Hello, TC. I've been alternating oral spironolactone (100-300 mg) and cyproterone acetate (50-200 mg) for just over a year now; I'll answer the questions in the relevant section of your OP as best I can.

If yes, how did it go for your hair?

Wonderfully. I went from a NW 3.5 with thinning in a NW 5A pattern to a very decent NW 2 in an exceedingly short period of time.

How were the sides?

On spironolactone, the sides were very mild... slight loss of sex drive and and decreased facial oiliness, in addition to the obvious diuretic side effect. The androgen-related sides were essentially unnoticeable up to 300 mg, although from what I gather, I am an aberration in that regard. The cyproterone acetate was different; at the highest doses, it all but killed my sex drive, and would often leave me in a state of lethargy. I would intermittently get random aches throughout my body. Facial oiliness and scalp itch were completely nonexistent. My body hair thinned out on both spironolactone and cyproterone acetate, although I would consider that a positive. Facial hair growth seemed to be inhibited. Oh, and spironolactone gave me VERY vivid dreams; as strange as that sounds, a few other guys on spiro reported the same thing over at another hairloss forum. No facial feminisation or (perceptible) muscle loss whatsoever.

Another thing that concerns me, it seems like this drug has not been studied much for andro alopecia in men. I would be more scared of it not working than the sides tbh

It was very, very efficacious for me, especially in light of the fact that my hair had previously actually marginally worsened after a year on finasteride.

Very great informative post, exactly something I wanted to see when I started this thread. Thanks!!
Can I ask....since you are alternating between 2 drugs that reduce androgens, do you think your results were more from cyproterone acetate than spiro? How can you know what drug was doing the heavy lifting?
Also how much do you think your facial hair growth was reduced? Can you give a rough %? I want to avoid feminization as much as I can, only thing I do not care about is body hair

[25 going on 65]

I also should have asked.....were you usign anything else w/ these medications that could promote hair growth? Minox, nizoral, etc? Also did you stay on finasteride?

[Bjimmy]

why are you alternating between two drugs? And can you go into more detail on the regime and time period?

No one particular reason. After ~2 months of spiro, I decided to switch to cyproterone acetate because I'd heard it was more effective for hair loss; after two months of that, I used spiro and cyp. acetate concomitantly for another two months because someone on another forum had very nice results on such a regimen. I then figured that there was probably no point stacking a weak and strong antiandrogen together (much like how there's absolutely no benefit in fin + dut over dut alone), so I dropped the spiro. A while after that, I decided I didn't want to risk the possible liver toxicity and switched back to spiro. A while after THAT, I found a doctor who would monitor my liver enzymes and switched back to cyp. acetate. Etc. There was no particular reason for me vacillating between treatments, if that's what you were wondering. It certainly didn't factor into any concerted regimen.

Timeframe... I'll try to give it as accurately as I can, although lamentably I didn't keep any detailed logs.

2012:

July-September: Spiro 100mg
September-November: Cyp. Acetate 100mg
November-January: Spiro 200mg, Cyp. Acetate 50 then 100mg
January-mid March: Cyp. Acetate 100 then 200mg
Mid March-May: Nothing (bank was blocking the online pharmacy I was using to procure these medications)
May-July: Spiro 300mg (trying to recoup any losses that had occurred, although in hindsight I don't think there were any)
July-September: Cyp. Acetate 100mg
September-Now: Spironolactone 100 then 200mg (switched because it was cheaper)

As you can see, it's laughable to even call it a regimen. I wish I'd been more consistent so that my case could be of more use to others, but... eh.

Can I ask....since you are alternating between 2 drugs that reduce androgens, do you think your results were more from cyproterone acetate than spiro? How can you know what drug was doing the heavy lifting?

That's honestly very difficult to say. There were no perceptible results after my first two months of spiro, whereas two months into cyproterone acetate there was rather marked regrowth that suddenly made me feel like a normal 19 year old again. Results sort of plateaued when I was using them concomitantly (or at least the speed of regrowth slowed to a significant degree). At the time I obviously felt that cyproterone acetate contributed more, although in hindsight it may have simply expedited things, or I could even be attributing delayed-onset spiro regrowth to the cyproterone. Honestly, it's very difficult to say. My almost complete lack of sides on spiro, and the timeframes involved, would probably still lead me to believe that the cyproterone was more effective. I'm sorry I can't give a more conclusive answer.

Also how much do you think your facial hair growth was reduced? Can you give a rough %? I want to avoid feminization as much as I can, only thing I do not care about is body hair

Oh, I'm sorry; I must have phrased that badly in my first post. My facial hair wasn't inhibited, exactly; rather, its proliferation was. I started this regimen at 19 (and fin at 18, before that) - consequently, I've not developed any more facial hair in years. Given that I didn't have much at 18 to begin with, well... let's just say it looks rather incongruous. Antiandrogen therapy doesn't reduce existing facial hair, though (even in transgender mtf regimens, much to their chagrin), so if you're truly 25 (or 28 now) you'd have absolutely nothing to worry about. Oh, and speaking of feminisation, something I forgot to mention in my OP - I didn't get the 'feminine, glowing skin' from either of the drugs that people customarily report. So... hooray for thick, tough man-skin!

I also should have asked.....were you usign anything else w/ these medications that could promote hair growth? Minox, nizoral, etc? Also did you stay on finasteride?


I used finasteride for the first month of spiro and then never bothered refilling my prescription. From late October this year I've added a bunch of other stuff, but that's not really relevant to my antiandrogen results. The bulk of the past year and a half has been nothing but antiandrogens.

Btw, sorry if the above was difficult to understand; atm I'm in an environment that's REALLY not conducive to cogent writing, haha. Obviously, feel free to ask me to clarify any unclear points.

[25 going on 65]

why are you alternating between two drugs? And can you go into more detail on the regime and time period?

No one particular reason. After ~2 months of spiro, I decided to switch to cyproterone acetate because I'd heard it was more effective for hair loss; after two months of that, I used spiro and cyp. acetate concomitantly for another two months because someone on another forum had very nice results on such a regimen. I then figured that there was probably no point stacking a weak and strong antiandrogen together (much like how there's absolutely no benefit in fin + dut over dut alone), so I dropped the spiro. A while after that, I decided I didn't want to risk the possible liver toxicity and switched back to spiro. A while after THAT, I found a doctor who would monitor my liver enzymes and switched back to cyp. acetate. Etc. There was no particular reason for me vacillating between treatments, if that's what you were wondering. It certainly didn't factor into any concerted regimen.

Timeframe... I'll try to give it as accurately as I can, although lamentably I didn't keep any detailed logs.

2012:

July-September: Spiro 100mg
September-November: Cyp. Acetate 100mg
November-January: Spiro 200mg, Cyp. Acetate 50 then 100mg
January-mid March: Cyp. Acetate 100 then 200mg
Mid March-May: Nothing (bank was blocking the online pharmacy I was using to procure these medications)
May-July: Spiro 300mg (trying to recoup any losses that had occurred, although in hindsight I don't think there were any)
July-September: Cyp. Acetate 100mg
September-Now: Spironolactone 100 then 200mg (switched because it was cheaper)

As you can see, it's laughable to even call it a regimen. I wish I'd been more consistent so that my case could be of more use to others, but... eh.

Can I ask....since you are alternating between 2 drugs that reduce androgens, do you think your results were more from cyproterone acetate than spiro? How can you know what drug was doing the heavy lifting?

That's honestly very difficult to say. There were no perceptible results after my first two months of spiro, whereas two months into cyproterone acetate there was rather marked regrowth that suddenly made me feel like a normal 19 year old again. Results sort of plateaued when I was using them concomitantly (or at least the speed of regrowth slowed to a significant degree). At the time I obviously felt that cyproterone acetate contributed more, although in hindsight it may have simply expedited things, or I could even be attributing delayed-onset spiro regrowth to the cyproterone. Honestly, it's very difficult to say. My almost complete lack of sides on spiro, and the timeframes involved, would probably still lead me to believe that the cyproterone was more effective. I'm sorry I can't give a more conclusive answer.

Also how much do you think your facial hair growth was reduced? Can you give a rough %? I want to avoid feminization as much as I can, only thing I do not care about is body hair

Oh, I'm sorry; I must have phrased that badly in my first post. My facial hair wasn't inhibited, exactly; rather, its proliferation was. I started this regimen at 19 (and fin at 18, before that) - consequently, I've not developed any more facial hair in years. Given that I didn't have much at 18 to begin with, well... let's just say it looks rather incongruous. Antiandrogen therapy doesn't reduce existing facial hair, though (even in transgender mtf regimens, much to their chagrin), so if you're truly 25 (or 28 now) you'd have absolutely nothing to worry about. Oh, and speaking of feminisation, something I forgot to mention in my OP - I didn't get the 'feminine, glowing skin' from either of the drugs that people customarily report. So... hooray for thick, tough man-skin!

I also should have asked.....were you usign anything else w/ these medications that could promote hair growth? Minox, nizoral, etc? Also did you stay on finasteride?


I used finasteride for the first month of spiro and then never bothered refilling my prescription. From late October this year I've added a bunch of other stuff, but that's not really relevant to my antiandrogen results. The bulk of the past year and a half has been nothing but antiandrogens.

Btw, sorry if the above was difficult to understand; atm I'm in an environment that's REALLY not conducive to cogent writing, haha. Obviously, feel free to ask me to clarify any unclear points.

Excellent contributions you are making to this thread. Your crazy schedule of going between the drugs makes it hard to sort things out. But no one else having much experience w/ real antiandrogens has posted here yet
Cyproterone acetate sounds effective but seems like a heavy drug for hair loss. Not sure if I am ready for something like that but I will be singing a different tune if my case gets worse....
Since you switched back to spiro have you noticed any differences in hair? Or does it seem like you are maintaining?

[Bjimmy]

Your crazy schedule of going between the drugs makes it hard to sort things out.

Yeah, exactly; so sorry for that. If you want, I can PM you the links to various other threads on other forums that I used as reference points before embarking on this regimen.

Since you switched back to spiro have you noticed any differences in hair? Or does it seem like you are maintaining?

Improvement. Interminably slow improvement, it seems at times, but improvement nonetheless.

And yeah, I wouldn't recommend the cyproterone acetate either; its effect on testosterone production is much stronger than spiro, and even 50mg can send a lot of people down to female ranges. Not good at all.

[25 going on 65]

Your crazy schedule of going between the drugs makes it hard to sort things out.

Yeah, exactly; so sorry for that. If you want, I can PM you the links to various other threads on other forums that I used as reference points before embarking on this regimen.

Unfortunately there are no PMs here or I would say yes

[mpbsucks]

I ordered oral spiro last night. I can always quit if the sides are too strong, hair is too important not to take the risk

Hey 25 on 65, I've been coming the forum tonight and seen abunch of your threads; it seems we are in the same situation. I went from fin to dut and then stopped antiandgrogens altogther to see if I was allergic or something. I have been thinking about trying spiro but I cannot find it in solution form. Are you ordering the cream? That would be a nightmare to apply right? Anyways lemme know if it works for you and where your getting it from.