Fin Doseage Question...

[JulioGP]

Guys can someone address why 0.05mg/day would not be the best way to take this drug?

Look at the chart, slight decrease after one dose at 0.04mg. We know that daily doses of 0.05mg cuts DHT by 50%, and Serum DHT by 62% (which is almost the same as for 1mg). So take daily doses of 0.05 and your DHT slowly decreases by 50%, rather than a rapid drop after one daily dose at a higher amount.

Someone please explain why it would not be best to do 0.05mg/day.

Dan26,

You mean 0.5mg instead 0.05mg day?

[KO1]

Guys can someone address why 0.05mg/day would not be the best way to take this drug?

Look at the chart, slight decrease after one dose at 0.04mg. We know that daily doses of 0.05mg cuts DHT by 50%, and Serum DHT by 62% (which is almost the same as for 1mg). So take daily doses of 0.05 and your DHT slowly decreases by 50%, rather than a rapid drop after one daily dose at a higher amount.

Someone please explain why it would not be best to do 0.05mg/day.

Because serum DHT concentration is not the same as hair counts. Furthermore, we know for a FACT that a dosage less than 0.2 mg daily is not as good as 1mg daily. There is no reason to believe that 0.05mg a day is advisable.

[KO1]

Thanks guys for all the above, this stuff is frightening to me, but if i were to try it, would 0.25mg Mon and Thurs be ok do you think? I guess it's down to me to try it ultimately tho..

This is unlikely to be effective. But you can try it if you want. Personally, what I would do if I were you and suffered sides, is take 0.25 mg about 3x a week, evaluate, and then continue to increase until you're taking 0.25mg everyday.

The problem for you is that (from what I read) you had no sides initially, but later on they developed, so in a sense, just because you tolerate it now, does not mean you will tolerate in the future. But with a lower dosage, it should be reduced. May I ask what nature of sides did you get, and how severe they were?

[KO1]

But it is up to you. You can take as little or as much as you want. 0.05mg, well get a microscope.

[Jcm800]

This is unlikely to be effective. But you can try it if you want. Personally, what I would do if I were you and suffered sides, is take 0.25 mg about 3x a week, evaluate, and then continue to increase until you're taking 0.25mg everyday.

The problem for you is that (from what I read) you had no sides initially, but later on they developed, so in a sense, just because you tolerate it now, does not mean you will tolerate in the future. But with a lower dosage, it should be reduced. May I ask what nature of sides did you get, and how severe they were?

You must be thinking of someone else mate, I've never taken the drug.

I'm always on here asking questions about it tho.

[KO1]

Ok, I had you mixed with Julio. Just do what you're comfortable with, but remember, 1mg is the "sweet spot" dosage for the widest group of people, you may do well on a lower dosage, you may not.

[Jcm800]

Ok, I had you mixed with Julio. Just do what you're comfortable with, but remember, 1mg is the "sweet spot" dosage for the widest group of people, you may do well on a lower dosage, you may not.

Just want to start off at a low level really, without shocking my system, but at what level I'm not sure.. How long have you been on it? You sure sing it's praises dude

[KO1]

Julio, I read your post, your sides sound strong, so you may be better off using something like RU.

[Dan26]

Because serum DHT concentration is not the same as hair counts. Furthermore, we know for a FACT that a dosage less than 0.2 mg daily is not as good as 1mg daily. There is no reason to believe that 0.05mg a day is advisable.

Ok, but look at dose ranging studies. There is a direct correlation between SCALP DHT and HAIR COUNT. 1mg reduced scalp DHT by more than 0.2mg, and haircount is higher. Same holds true for the other doses. Makes sense, right? 0.05mg/day has only 2% less scalp DHT reduction than 1mg. It SHOULD have similar haircount, if they were to test it in dose ranging studies. AND, serum DHT is only reduced by 50%, much less than 1mg.

And how do we know for a FACT dosage less than 0.2mg daily is not as good as 1mg daily?? It wasn't even tested! Besides 0.01, which obviously blows as it was on par with placebo.

So again, if 0.05mg/day reduces SCALP SHT by almost the same as 1mg/day, what makes you think hair count would not be almost the same aswell? The fact there was no dose ranging study for 0.05/day, when they knew it reduced scalp DHT by almost he same as 1mg/day, yet serum DHT by 20% less (less side effects ), makes absolutely no sense whatsoever at all point blank period

[KO1]

And how do we know for a FACT dosage less than 0.2mg daily is not as good as 1mg daily?? It wasn't even tested! Besides 0.01, which obviously blows as it was on par with placebo.

Efficacy was demonstrated for all end points for finasteride at doses of 0.2 mg/day or higher, with 1 and 5 mg demonstrating similar efficacy that was superior to lower doses. Efficacy of the 0.01 mg dose was similar to placebo. No significant safety issues were identified in the trials.

http://www.ncbi.nlm.nih.gov/pubmed/10495375

[Dan26]

http://www.ncbi.nlm.nih.gov/pubmed/10495375

Dude...stop....lol

You are missing the point!

I GET IT! WE CAN ONLY KNOW FOR CERTAIN THE EFFECT ON HAIRCOUNT FOR THE DOSES THAT WERE TESTED.

BUT ANSWER THIS QUESTION FOR ME PLEASE...

WHAT MAKES YOU THINK THAT, IF 0.05mg/day WAS CHOSEN TO BE TESTED TOO, IT WOULD NOT PERFORM ON PAR WITH 1mg/day???

Give me a reason, BESIDES the fact that it wasn't actually tested.

[KO1]

I repeat, we know for a FACT that less than 1mg is not as effective as 1mg (the study I posted says that). Given that 0.05mg is < 1mg, there's strong reason to believe that it is not as effective

[JulioGP]

K01
I do not feel safe to use the RU, I think that few studies have been done on this drug. I would venture on Finasteride with a lower dosage.

If we look at the chart that is quoted "scalp DHT", Dan26 would be right.

Really there was no difference between the dosages of 0.05mg and 1mg. When using the 0.2mg dose of DHT in the scalp was still greater, which is something strange.

I posted this study because I think that everyone takes a very high dosage without needed. Would only have to evaluate whether the study was done only in one individual or in a group.

Another thing is that here in Brazil, we have only the dosage of 1mg and 5mg. To share one 1mg tablet in half is easy, but to share 1mg in 0.05mg is virtually impossible to do it at home, and can ruin the medicine and undermine its effect.

But I agree that the graph, the same effect would 0.05mg and 1mg.

Perhaps the easiest to do and that is not in the graph would take 0.5mg every other day. I think there would be much change compared to 0.05 to 1mg.

[Jcm800]

So, in simple terms and ease of cutting, is half of a 1mg tablet a good place to start EOD or is a quarter going to be worthwhile twice a week?

[JulioGP]

So, in simple terms and ease of cutting, is half of a 1mg tablet a good place to start EOD or is a quarter going to be worthwhile twice a week?

Not sure I understand your question correctly (language problems), but it would be efficient and effective take 0.5mg every other day. In theory, it would almost the same effect as a dose of 1 mg daily.