So just to be clear, you are saying that the PGD2 and DHT are not in the blood that is delivered to the sides of your head? But they are in the blood that is delivered to the top?
Prostaglandin Graphic
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if anything dr costerlais research has created more questions than it has answered.
dht-> cox2 -> pgd2
for one reason or another the follicles at the top seem to be heavily affected by dht-> cox2 ->pgd2.
dht->cox2->pgd2 is present in ALL hair follicles.Comment
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In the study it says "We show that prostaglandin D2 synthase (PTGDS) is elevated at the mRNA and protein levels in bald scalp compared to haired scalp of men with AGA.". I wonder if they meant follicle instead of scalp. Obviously the cure is in the follicle, or else hair transplants would not work. Maybe hair follicles on top of our head have more GPR44 receptors.Comment
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In the study it says "We show that prostaglandin D2 synthase (PTGDS) is elevated at the mRNA and protein levels in bald scalp compared to haired scalp of men with AGA.". I wonder if they meant follicle instead of scalp. Obviously the cure is in the follicle, or else hair transplants would not work. Maybe hair follicles on top of our head have more GPR44 receptors.Comment
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As usual scientists and doctors are just coming up with treatments, not cures. Oh it must be too much DHT, lets block it all and screw with your whole endocrine system. Oh its PGD2, lets figure out howto block it. The problem is in the follicle. Why cant someone just figure this shit out. We don't have the technology to accurately compare 2 hair follicles?Comment
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So is everyone saying that the follicles CRTH2 receptor is uptaking PGD2 and causing the hair not to grow? If that's the case, then why do only the follicles on the top of our heads do it, not the sides? The same amount of PGD2 would be running through our blood to the sides of our head.Comment
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As usual scientists and doctors are just coming up with treatments, not cures. Oh it must be too much DHT, lets block it all and screw with your whole endocrine system. Oh its PGD2, lets figure out howto block it. The problem is in the follicle. Why cant someone just figure this shit out. We don't have the technology to accurately compare 2 hair follicles?Comment
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I agree totally. Would not a COMPLETE comparison between donor and recepient sites in an AGA victim versus a COMPLETE comparison between a "lucky sob" without AGA not yield some results? How about comparing the two? Surely a comprehensive analysis would yield something! You would think that balding, in a pattern, would be easier to define if it were simply and only determined by a gene.
comparisons have been done with regards to 5 alpha reductase activity between differnet regions of the scalp as well as hormonal profiles of aga victims against non aga victims.
baldness is not genetic as you are being taught.
Dormancy is a cancer prevention mecahanism used by the body in times when over expression of cox2 enzymes gets over the limit the body decides to shut down production to prevent cancer.
In effect - baldness is your bodies way of stopping you from getting folliclular cancer!Comment
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As usual scientists and doctors are just coming up with treatments, not cures. Oh it must be too much DHT, lets block it all and screw with your whole endocrine system. Oh its PGD2, lets figure out howto block it. The problem is in the follicle. Why cant someone just figure this shit out. We don't have the technology to accurately compare 2 hair follicles?
Also with fin there not blocking DHT there lowering it, even in not AGA scalps DHT is there
Also there not blocking PGD2 there talking about stopping the elevated PGD2 from binding to the CRTH2 Receptor.
PGD2 is just one of the Prostaglandins..
its not the follicles thats the problem its the environment within the scalpComment
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Dormancy is a cancer prevention mecahanism used by the body in times when over expression of cox2 enzymes gets over the limit the body decides to shut down production to prevent cancer.
In effect - baldness is your bodies way of stopping you from getting folliclular cancer!Comment
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its not the follicles thats the problem its the environment within the scalpComment
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in simple terms baldness is due to over expression of cox2 initiated by androgens.
over expression of cox2 is known to cause cancer.Comment
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HT's are only perceieved to work...
the men who get ht's are usually men in their 40-50's..those mens hormonal profile natrually declines with age thus reducing the possibility of transplanted hairs being damaged due to excess dht/androgens.
This is the reason why ht's work and the reason why the rate of hair loss declines with age and the reason why some mens hair loss stops at nw2.
If you got a hair from the donor regions and pumped it full of dht, you will almost certainly see them minutuarise.Comment
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Yet the Androgen receptors on the back of our head aren't susceptible? Sounds like you are trying to point to inflammation as the culprit like others do. How do you explain the marked difference from top and back of our heads though?Comment
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HT's are only perceieved to work...
the men who get ht's are usually men in their 40-50's..those mens hormonal profile natrually declines with age thus reducing the possibility of transplanted hairs being damaged due to excess dht/androgens.
This is the reason why ht's work.
If you got a hair from the donor regions and pumped it full of dht, you will almost certainly see them minutuarise.Comment
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