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Example 1
Method of Treatment of Skin
A method according to the present invention for effecting treatment of the skin on a human scalp is performed as follows. A subject with near complete hair loss and mild dyspigmentation on the scalp is seated in a stationary examination chair.
Next, using a programmed protocol for treating physical features that are known to be present on the subject's scalp (the practitioners having assessed the subject's scalp, determined that germane features included “featureless” areas of skin, age spots, terminal hairs, and sweat glands, and provided such information to the computer in order to trigger the use of an appropriate protocol), the computer positions a fractional laser above the scalp, and the laser is activated for a prescribed time and at a prescribed power for removal of a column of tissue at the target area to a depth of about 1 mm, thereby forming a channel at the location of injury. Using a protocol that is appropriate for an area in which a channel has been formed, the computer positions an applicator at a location above the scalp that corresponds to the site of injury in the second further target area. The applicator includes an inkjet-type head for delivering a composition substantially directly into the channel. A small volume (about 50 μL) of a composition comprising 6-bromo-indirubin-3′-oxime (a GSK3β modulator) and carrier comprising PEO-PPO-PEO (a thermoreversible polymer that gels when exposed to human physiological temperatures) is delivered as a fluid to the location.
The computer then uses the preprogrammed protocol to select a new target area on the portion of the scalp that is precisely 4 mm “above” (i.e., at a 90° angle from) the first target area. The selection of the further target area is in accordance with a preset directive that instructs the computer to select further target areas from a rectilinear grid defined by points that are separated from one another by 4 mm.
Next, using the programmed protocol for treating a scalp having the characteristics described above, the computer positions an applicator that is configured for propelling particles at a location above the scalp that corresponds to the further target area, and the applicator is activated for a prescribed time to deliver lithium-containing particles at a prescribed velocity (calculated to penetrate the skin to a depth of 1 to 3 mm) at the location of the further target area. Using a protocol that is appropriate for an area that has been bombarded with lithium-containing particles, the computer positions a second applicator at a location above the scalp that corresponds to the further target area. The applicator includes a spray nozzle for delivering a composition to the body surface. A small volume (about 50 μL) of a composition comprising aminoxidil and an appropriate excipient is delivered as a fluid to the location.
The computer again uses the preprogrammed protocol to select a new target area (a “second further target area”) on the portion of the scalp that is precisely 4 mm “above” (i.e., at a 90° angle from) the further target area. In accordance with the preprogrammed protocol for treating a scalp having the characteristics described above, the computer again positions a fractional laser above the scalp, and the laser is activated for a prescribed time and at a prescribed power for removal of a column of tissue at the second further target area to a depth of about 1 mm, thereby forming a channel at the location of the second further target area. Using the protocol that is appropriate for an area in which a channel has been formed, the computer positions an applicator at a location above the scalp that corresponds to the site of injury in the second further target area. The applicator includes an inkjet-type head for delivering a composition substantially directly into the channel. A small volume (about 50 μL) of a composition comprising 6-bromo-indirubin-3′-oxime and carrier comprising acrylate-lactate-PEO-PPO-PEO-lactate-acrylate is delivered as a fluid to the location.
The computer again uses the preprogrammed protocol to select a new target area (a “third further target area”) on the portion of the scalp that is precisely 4 mm “above” (i.e., at a 90° angle from) the second further target area. Once again using the programmed protocol for treating a scalp having the characteristics described above, the computer positions the applicator that is configured for propelling particles at a location above the scalp that corresponds to the third further target area, and the applicator is activated for a prescribed time to deliver lithium-containing particles at a prescribed velocity (calculated to penetrate the skin to a depth of 1 to 3 mm) at the location of the further target area. Using a protocol that is appropriate for an area that has been bombarded with lithium-containing particles, the computer positions a second applicator at a location above the scalp that corresponds to the third further target area. The applicator includes a spray nozzle for delivering a composition to the body surface. A small volume (about 50 μL) of a composition comprising aminoxidil and an appropriate excipient is delivered as a fluid to the location.
The described process is performed iteratively to give rise to additional target areas, wherein the additional target areas form a rectilinear grid relative to the portion of scalp.
Taken from Follicas most recent patent
Method of Treatment of Skin
A method according to the present invention for effecting treatment of the skin on a human scalp is performed as follows. A subject with near complete hair loss and mild dyspigmentation on the scalp is seated in a stationary examination chair.
Next, using a programmed protocol for treating physical features that are known to be present on the subject's scalp (the practitioners having assessed the subject's scalp, determined that germane features included “featureless” areas of skin, age spots, terminal hairs, and sweat glands, and provided such information to the computer in order to trigger the use of an appropriate protocol), the computer positions a fractional laser above the scalp, and the laser is activated for a prescribed time and at a prescribed power for removal of a column of tissue at the target area to a depth of about 1 mm, thereby forming a channel at the location of injury. Using a protocol that is appropriate for an area in which a channel has been formed, the computer positions an applicator at a location above the scalp that corresponds to the site of injury in the second further target area. The applicator includes an inkjet-type head for delivering a composition substantially directly into the channel. A small volume (about 50 μL) of a composition comprising 6-bromo-indirubin-3′-oxime (a GSK3β modulator) and carrier comprising PEO-PPO-PEO (a thermoreversible polymer that gels when exposed to human physiological temperatures) is delivered as a fluid to the location.
The computer then uses the preprogrammed protocol to select a new target area on the portion of the scalp that is precisely 4 mm “above” (i.e., at a 90° angle from) the first target area. The selection of the further target area is in accordance with a preset directive that instructs the computer to select further target areas from a rectilinear grid defined by points that are separated from one another by 4 mm.
Next, using the programmed protocol for treating a scalp having the characteristics described above, the computer positions an applicator that is configured for propelling particles at a location above the scalp that corresponds to the further target area, and the applicator is activated for a prescribed time to deliver lithium-containing particles at a prescribed velocity (calculated to penetrate the skin to a depth of 1 to 3 mm) at the location of the further target area. Using a protocol that is appropriate for an area that has been bombarded with lithium-containing particles, the computer positions a second applicator at a location above the scalp that corresponds to the further target area. The applicator includes a spray nozzle for delivering a composition to the body surface. A small volume (about 50 μL) of a composition comprising aminoxidil and an appropriate excipient is delivered as a fluid to the location.
The computer again uses the preprogrammed protocol to select a new target area (a “second further target area”) on the portion of the scalp that is precisely 4 mm “above” (i.e., at a 90° angle from) the further target area. In accordance with the preprogrammed protocol for treating a scalp having the characteristics described above, the computer again positions a fractional laser above the scalp, and the laser is activated for a prescribed time and at a prescribed power for removal of a column of tissue at the second further target area to a depth of about 1 mm, thereby forming a channel at the location of the second further target area. Using the protocol that is appropriate for an area in which a channel has been formed, the computer positions an applicator at a location above the scalp that corresponds to the site of injury in the second further target area. The applicator includes an inkjet-type head for delivering a composition substantially directly into the channel. A small volume (about 50 μL) of a composition comprising 6-bromo-indirubin-3′-oxime and carrier comprising acrylate-lactate-PEO-PPO-PEO-lactate-acrylate is delivered as a fluid to the location.
The computer again uses the preprogrammed protocol to select a new target area (a “third further target area”) on the portion of the scalp that is precisely 4 mm “above” (i.e., at a 90° angle from) the second further target area. Once again using the programmed protocol for treating a scalp having the characteristics described above, the computer positions the applicator that is configured for propelling particles at a location above the scalp that corresponds to the third further target area, and the applicator is activated for a prescribed time to deliver lithium-containing particles at a prescribed velocity (calculated to penetrate the skin to a depth of 1 to 3 mm) at the location of the further target area. Using a protocol that is appropriate for an area that has been bombarded with lithium-containing particles, the computer positions a second applicator at a location above the scalp that corresponds to the third further target area. The applicator includes a spray nozzle for delivering a composition to the body surface. A small volume (about 50 μL) of a composition comprising aminoxidil and an appropriate excipient is delivered as a fluid to the location.
The described process is performed iteratively to give rise to additional target areas, wherein the additional target areas form a rectilinear grid relative to the portion of scalp.
Taken from Follicas most recent patent
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