My MPB hypothesis.

[youngin]

I have been doing alot of reading lately about MPB since I read the study that implicated PGD-2 as the cause of it. One thing that stood out to me in that study was that there was an enlargement of sebaceous glands in balding areas. All of this reading got me wondering why in all of the cures and studies, no one has addressed why the side of our head never go bald.

To me it seems very simplistic.. what does the top of our head get that the rest of our head doesn't, A LOT OF SUNLIGHT. I found that an Indian doctor had implicated UV as the reason for MPB and wrote a book about it, unfortunately he wants like 300$ for the book, so I never got to read it. Upon more of my own research I came across this study: http://journal.scconline.org//pdf/cc...523-p00536.pdf which suggests that larger/more sebaceous glands may cause higher uptake of ALL testosterone, including DHT in balding scalps, than non-balding. It also proves that DHT is not really the culprit, ALL TYPES of testosterone are. Also, you can find studies that prove UV rays absolutely increase sebaceous glands.

My theory is this... Over years of our heads being exposed to the sun, many sebaceous glands continue to form. The more that form, the more the hair follicles are being blocked, and the more testosterone uptake there is. Since the sebaceous gland is pulling excessive testosterone into the follicle, the follicle will die or have a shortened anagen stage. Maybe the follicle even gets damaged so that it malfunctions by the process above.

Different thickness of hair, conditions, proximity to the sun, hair style, diet, etc would all effect the quickness which balding set in. Personally, I always had thin hair, I always kept it short, I had a bad diet, and my MPB set in when I was 17.

Has anyone tried medication that shrinks sebaceous glands, along with Minoxidil or something? I have read that Retin-A is proven to increase efficiency of Minoxidil.

[youngin]

From the study: "It has been reported that bald scalps contain larger sebaceous glands than hairy scalps (19) and since sebaceous glands are believed to be target organs for androgens (20) this may in part account for the greater uptake of testosterone by bald skin"

[FlightTL]

I have been doing alot of reading lately about MPB since I read the study that implicated PGD-2 as the cause of it. One thing that stood out to me in that study was that there was an enlargement of sebaceous glands in balding areas. All of this reading got me wondering why in all of the cures and studies, no one has addressed why the side of our head never go bald.

To me it seems very simplistic.. what does the top of our head get that the rest of our head doesn't, A LOT OF SUNLIGHT. I found that an Indian doctor had implicated UV as the reason for MPB and wrote a book about it, unfortunately he wants like 300$ for the book, so I never got to read it. Upon more of my own research I came across this study: http://journal.scconline.org//pdf/cc...523-p00536.pdf which suggests that larger/more sebaceous glands may cause higher uptake of ALL testosterone, including DHT in balding scalps, than non-balding. It also proves that DHT is not really the culprit, ALL TYPES of testosterone are. Also, you can find studies that prove UV rays absolutely increase sebaceous glands.

My theory is this... Over years of our heads being exposed to the sun, many sebaceous glands continue to form. The more that form, the more the hair follicles are being blocked, and the more testosterone uptake there is. Since the sebaceous gland is pulling excessive testosterone into the follicle, the follicle will die or have a shortened anagen stage. Maybe the follicle even gets damaged so that it malfunctions by the process above.

Different thickness of hair, conditions, proximity to the sun, hair style, diet, etc would all effect the quickness which balding set in. Personally, I always had thin hair, I always kept it short, I had a bad diet, and my MPB set in when I was 17.

Has anyone tried medication that shrinks sebaceous glands, along with Minoxidil or something? I have read that Retin-A is proven to increase efficiency of Minoxidil.

Could a healthy diet help to reduce over active sebaceous gland? Perhaps.

[youngin]

I think it would. I haven't researched anything specifically that will shrink them, but I am positive that the growth hormone in Milk stimulates the sebaceous glands. This has been proven in studies of Acne. Anything that boosts testosterone or HGH will stimulate your sebaceous glands. Including heavy weight lifting. That doesn't mean not to do it. I think the point is not to be exposed to the sun for too long at a time.

[2020]

I have been doing alot of reading lately about MPB since I read the study that implicated PGD-2 as the cause of it. One thing that stood out to me in that study was that there was an enlargement of sebaceous glands in balding areas. All of this reading got me wondering why in all of the cures and studies, no one has addressed why the side of our head never go bald.

To me it seems very simplistic.. what does the top of our head get that the rest of our head doesn't, A LOT OF SUNLIGHT. I found that an Indian doctor had implicated UV as the reason for MPB and wrote a book about it, unfortunately he wants like 300$ for the book, so I never got to read it. Upon more of my own research I came across this study: http://journal.scconline.org//pdf/cc...523-p00536.pdf which suggests that larger/more sebaceous glands may cause higher uptake of ALL testosterone, including DHT in balding scalps, than non-balding. It also proves that DHT is not really the culprit, ALL TYPES of testosterone are. Also, you can find studies that prove UV rays absolutely increase sebaceous glands.

My theory is this... Over years of our heads being exposed to the sun, many sebaceous glands continue to form. The more that form, the more the hair follicles are being blocked, and the more testosterone uptake there is. Since the sebaceous gland is pulling excessive testosterone into the follicle, the follicle will die or have a shortened anagen stage. Maybe the follicle even gets damaged so that it malfunctions by the process above.

Different thickness of hair, conditions, proximity to the sun, hair style, diet, etc would all effect the quickness which balding set in. Personally, I always had thin hair, I always kept it short, I had a bad diet, and my MPB set in when I was 17.

Has anyone tried medication that shrinks sebaceous glands, along with Minoxidil or something? I have read that Retin-A is proven to increase efficiency of Minoxidil.

https://www.youtube.com/watch?v=5hfYJsQAhl0

[youngin]

Yah, its so ridiculous that's why a doctor wrote a book about it...

http://www.quithairloss.com/new-book.html

And study:

http://www.ncbi.nlm.nih.gov/pubmed/19138021

2020 is such a genius. He has figured out the problem its PGD-2. LOL. Read the studies you asshole.

[2020]

Yah, its so ridiculous that's why a doctor wrote a book about it...

http://www.quithairloss.com/new-book.html

yup... that's how it always is. Some "doctor" has a cure for something and it's available to everyone for just $29.99!

Anyone can write a book you idiot

And study:

http://www.ncbi.nlm.nih.gov/pubmed/19138021

it's funny how the opposite is actually observed: northern europeans bald like crazy with little sunshine and there is little baldness in all those south american countries. Amazing how australian aborigines have virtually no baldness.

are you ****ing kidding me? sunshine causes baldness??? take your crap to IH forums

2020 is such a genius. He has figured out the problem its PGD-2. LOL. Read the studies you asshole.

I didn't figure that out. Scientists did back in 2007. When you apply PGD2, follicle shrinks. It's not actually all PGD2 either. Upregulated inflammation in general is probably the cause of baldness. Even his patent describes a way of treating baldness by just using a COX-2 inhibitor... More than one person has reversed baldness by reducing inflammation

[youngin]

There's no proof of the cause in any study. PGD-2 may very well be a bi-product of the real CAUSE. Your guesses are just as hypothetical as mine. Blaming PGD-2 doesn't explain why hairs on the side of our heads don't suffer the same as the top, and also why hair transplants WORK. So quit pretending like you know it all. Did you even read the first study I posted?

There's tons of factors that could cause one persons scalp to have more or less sun exposure than another persons. I guess no one in northern Europe ever gets skin cancer either huh? Use your ****in eyes and do some research as to what causes cancers and acne. The possible causes of cell mutation are endless. Enlighten yourself. You sure are stupid for someone who thinks they know everything.

[youngin]

http://www.nature.com/jid/journal/v1...d2008418a.html Read up jackass. Now dispute that study please while I laugh at your stupidity.

[2020]

There's no proof of the cause in any study. PGD-2 may very well be a bi-product of the real CAUSE. Your guesses are just as hypothetical as mine.

right, inflammation. PGD2 is directly responsible for shrinking follicles. The real cause of elevated PGD2 is probably inflammation and not ****ing sunshine.

Blaming PGD-2 doesn't explain why hairs on the side of our heads don't suffer the same as the top, and also why hair transplants WORK. So quit pretending like you know it all. Did you even read the first study I posted?

oh thanks for mentioning that - WHY don't they respond to "sunshine damage" then?

There's tons of factors that could cause one persons scalp to have more or less sun exposure than another persons. I guess no one in northern Europe ever gets skin cancer either huh? Use your ****in eyes and do some research as to what causes cancers and acne. The possible causes of cell mutation are endless. Enlighten yourself. You sure are stupid for someone who thinks they know everything.

amazing... prostate cancer is linked with baldness and lack of sunshine is linked to prostate cancer. Nothing fits

by the way:

We are aware that it is rather unlikely that normal human hair bulbs are exposed to UVB doses as high as 20 or 50 mJ cm−2 in situ. Therefore, we do not claim that our model imitates the actual in vivo situation.

so what is your solution to this? Avoid sunshine?

[youngin]

Its a hypothesis that's alot stronger than yours. If you don't like it, then don't comment. Quit being a ****ing troll just because you think you know everything.

[2020]

Its a hypothesis that's alot stronger than yours. If you don't like it, then don't comment. Quit being a ****ing troll just because you think you know everything.

who says I know everything? I never even knew about PGD2 before that study came out...

answer my questions:

if sunshine causes baldness, how come you're not balding all over?
prostate cancer is linked to baldness AND lack of sunshine. How would you explain that?
that study says that a person is very unlikely to experience that much ultraviolet radiation.

and again: what do you propose we do if your theory is right?

[youngin]

right, inflammation. PGD2 is directly responsible for shrinking follicles. The real cause of elevated PGD2 is probably inflammation and not ****ing sunshine.

Even if its true, what cause inflammation ONLY ON THE TOP OF YOUR HEAD?? HUH? Explain it please.

oh thanks for mentioning that - WHY don't they respond to "sunshine damage" then?

Use some ****in common sense, you ever had a sunburn on the side of your head? Go stand outside or play some sports and see what parts of you get burned first. The top of your head, top of your shoulders/back. The top of your head is exposed to the sun far more than any other part of your body in your life.

amazing... prostate cancer is linked with baldness and lack of sunshine is linked to prostate cancer. Nothing fits

Inflammation is linked to diet, and diet is linked to obesity, so all obese people must be bald! NOTHINGS FITS!

by the way:
Therefore, we do not claim that our model imitates the actual in vivo situation.

They would be stupid to make that claim, then be quoted by other doctors as proof. It's not empirical proof, but its a hell of alot better than your proof.

so what is your solution to this? Avoid sunshine?

Who said I had a solution?

People like you are the reason forums go down the shitter. I make a simple hypothesis and want some logical debate and you come in just to insult me. ****ing troll. Go away.

[2020]

Even if its true, what cause inflammation ONLY ON THE TOP OF YOUR HEAD?? HUH? Explain it please.

microinflammation? There was that study where they found more 5AR in balding sites so that's why "balding zones" go away faster than "donor sites". Overtime you would go bald all over.

Use some ****in common sense, you ever had a sunburn on the side of your head? Go stand outside or play some sports and see what parts of you get burned first. The top of your head, top of your shoulders/back. The top of your head is exposed to the sun far more than any other part of your body in your life.

amazing... how come it starts with a recession then? Sides and donor do thin. How come removing androgens cures MPB despite sunshine?

Inflammation is linked to diet, and diet is linked to obesity, so all obese people must be bald! NOTHINGS FITS!

DHT is not always inflammatory and yes insulin resistance(obesity?) has been linked to baldness. It fits.

They would be stupid to make that claim, then be quoted by other doctors as proof. It's not empirical proof, but its a hell of alot better than your proof.

what my proof are you talking about!??! I haven't said anything new. It's all in this patent:

http://www.google.com/patents/US20110021599?ei=mPY8ULuoMOjaywHe8IDYAQ

they proved that PGD2 inhibits hair growth while getting rid of PGD2 restores hair growth. What's the problem?

Who said I had a solution?

People like you are the reason forums go down the shitter. I make a simple hypothesis and want some logical debate and you come in just to insult me. ****ing troll. Go away.

your hypothesis is probably the worst I've ever read...

why do balding people have so much body hair? How come they associate so many other health problems with balding?

[youngin]

You look down a tunnel. I can adequately answer all of your questions, and you could too if you stopped being such a know it all. I wont be responding to anymore of your comments.