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  1. #11
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    Feb 2011
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    Some thoughts on TRT, please feel free to weigh in:

    I personally feel testosterone therapy will not have the desired impact as finasteride has created some sort of intracellular down-regulation of 5AR activity. In this sense, your body has been endocrinologically moved toward converting more test into estradiol, if estradiol is excessive your body simply reduces its 'baseline' production of testosterone. So individuals are now left with the symptoms of low testosterone, but remember that testosterone production is something the body has no problem with, it's the down-regulated activity of 5AR that is pushing estradiol up and reducing the activity of neurosteroids throughout the nervous system. Doctors simply look at the low testosterone levels and put the patient on TRT, so now they have created two problems from one, not only has the body gained an intracellular down-regulation of 5AR, but it is now with the belief that it does not need to naturally produce any more testosterone due to the new exogenous supply. The problems may seem resolved, as the return of increased testosterone alleviates some symptoms, but the root of the problem is still there, and what is all that excess testosterone being converted to? That's right, ESTRADIOL.

    DHT therapy might help, but will it last? That's the main concern, some people suffering from PFS have had some success with Proviron - but nothing amazing which tells me something serious has gone wrong with the function of 5AR. The fact that some individuals feel as if they have entered some prepubertal state also indicates that finasteride may have destroyed a large proportion of androgen receptors, if something in your body is not in use, the body will simply remove it.

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