baldness treatment may lie in stressed hair follicles

[Mentalist]

http://ajw.asahi.com/article/behind_...AJ201207140020

[UK_]

They mention "proteins that guide the immune cells" - could this have any relation to Dr Cots study surrounding PGD2??

[neversaynever]

They mention "proteins that guide the immune cells" - could this have any relation to Dr Cots study surrounding PGD2??

Yea totally, PGd2 is involved there. So its a paradox. The hair cells sense a problem, they signal for immune cells, immune cells produce pgd2, death of follicle?

Rather than 'stress applied to skin'. For MPB, its the immune system reacting to DHT?

http://www.nature.com/ni/journal/vao...l/ni.2353.html

Thats the study. Heres another that says Langerhans cells release PGd2...

http://www.nature.com/jid/journal/v1.../5700586a.html

[neversaynever]

Im noticing the rate in which new information is become available is getting faster and faster...

[john2399]

As long as they keep finding these new discoveries, i have no problem with it. We can say atleast they are working on it and didn't give up on baldness.

[bananana]

what about scalproller? it's also stress for the follicules - but it helps growth?

[UK_]

Yea totally, PGd2 is involved there. So its a paradox. The hair cells sense a problem, they signal for immune cells, immune cells produce pgd2, death of follicle?

Rather than 'stress applied to skin'. For MPB, its the immune system reacting to DHT?

http://www.nature.com/ni/journal/vao...l/ni.2353.html

Thats the study. Heres another that says Langerhans cells release PGd2...

http://www.nature.com/jid/journal/v1.../5700586a.html

The way I read it is:

DHT (which is a very potent androgen) comes into contact with follicles, the follicles react by releasing proteins to guide immune cells to remove the DHT but they end up destroying the cells required for the follicle to regenerate over time, leading to thinner and thinner hair after every cycle because before each cycle another chunk of cells have been attacked by this process. Eventually the hair follicle is attacked so much that it is so small the immune system doesnt even recognise it as a problem (this links to Dr Cots study on hair follicles in slick bald scalps STILL producing microscopic invisible to the naked eye hairs). OR... the hair follicle is attacked so much it loses the ability to produce the proteins to call the immune cells.