Prostaglandin Graphic

[Davey Jones]

I was just reading about the 5-lox inhibition for combating inflammation, and I noticed that the other side of the cascade for archidonic acid is the production of prostaglandins (like PGE2 and PGD2). I've been trying to wrap my head around the whole prostaglandins thing recently, and this helped get a handle on things. Figured I'd post it:



I also have a few questions, if anyone is already all read up anyway.

It is my understanding that your hair would benefit from an environment heavy on the PGE2 and light on the PGD2, or that's one of the newer theories at least. OC000459 is said to block PGD2. It is a CRTH2 antagonist. Problem is...CRTH2 is not on that graphic. Does anyone know by what mechanism OC000459 lowers PGD2?

Are we sure that OC000459 is the only safe chemical out that can lower PGD2? Is there nothing that will inhibit the actions of PGD synthase, perhaps, as lipoxygenase inhibitors can lower levels of leukotrienes?

Lastly which chemicals are out/on the horizon that can promote/act as PGE2?

P.S. I know that there are many theories behind hairloss. Some competing, some related, some ambiguously competing/related. However, in this thread, I'd like to just discuss prostaglandins and their mechanisms and potential relation to hairloss.