Prostaglandin Graphic

[ferwin]

. The second form of attack would be PGD2 synthase inhibitory effects and PGD2 receptor blockers of some kind.

This could be one of the components you're looking for:


50% suppression of the PGD2 level by cetirizine

http://www.ncbi.nlm.nih.gov/m/pubmed/2469708/

ferwin

[CurlyBird]

One other thing, the ideal topical would actually be a shampoo that would have 5AR inhibitory effects, along with androgen receptor blocking molecules. The second form of attack would be PGD2 synthase inhibitory effects and PGD2 receptor blockers of some kind. Attacking the problem at 4 distinct steps would stop signalling nearly completely. Of course hairloss may be even more complex still but to date this is all we know.

In a nutshell it would have to be a shampoo with 4 different molecules that can be absorbed locally. A big ask but not impossible.

Unfortunately, there is research that shows topical finasteride is absorbed systemically. So a topical 5-AR inhibitor would not necessarily be preferable. And should it be a shampoo, it better be able to penetrate the scalp easily and quickly or else most of the ingredients will be washed off.

[rdawg]

Any companies looking into creating a full-market product for this.

and anyone have any actual experience/results with using a PGD2 inhibitor?

It seems like a very worthy thing to go through a trial for.

Wouldn't it essentially be Minoxidil mixed with a PGD2 inhibitor? super minoxidil.

[youngin]

So is everyone saying that the follicles CRTH2 receptor is uptaking PGD2 and causing the hair not to grow? If that's the case, then why do only the follicles on the top of our heads do it, not the sides? The same amount of PGD2 would be running through our blood to the sides of our head.

[gutted]

So is everyone saying that the follicles CRTH2 receptor is uptaking PGD2 and causing the hair not to grow? If that's the case, then why do only the follicles on the top of our heads do it, not the sides? The same amount of PGD2 would be running through our blood to the sides of our head.

some believe its because of "genetics"

feed the back and sides with a continuous supply of pgd2(dht), and the hairs would minutuarise too but this doesnt happen because blood and lymphatic circulation/drainage is good in this region.

[youngin]

So just to be clear, you are saying that the PGD2 and DHT are not in the blood that is delivered to the sides of your head? But they are in the blood that is delivered to the top?

[gutted]

So just to be clear, you are saying that the PGD2 and DHT are not in the blood that is delivered to the sides of your head? But they are in the blood that is delivered to the top?

thats not what im saying...of course they are.

if anything dr costerlais research has created more questions than it has answered.

dht-> cox2 -> pgd2

for one reason or another the follicles at the top seem to be heavily affected by dht-> cox2 ->pgd2.

dht->cox2->pgd2 is present in ALL hair follicles.

[youngin]

In the study it says "We show that prostaglandin D2 synthase (PTGDS) is elevated at the mRNA and protein levels in bald scalp compared to haired scalp of men with AGA.". I wonder if they meant follicle instead of scalp. Obviously the cure is in the follicle, or else hair transplants would not work. Maybe hair follicles on top of our head have more GPR44 receptors.

[idw2bb]

In the study it says "We show that prostaglandin D2 synthase (PTGDS) is elevated at the mRNA and protein levels in bald scalp compared to haired scalp of men with AGA.". I wonder if they meant follicle instead of scalp. Obviously the cure is in the follicle, or else hair transplants would not work. Maybe hair follicles on top of our head have more GPR44 receptors.

Does not part of the scalp accompany the follicle in a hair transplant? Is there not evidence of cross-talk between internal and external components of the scalp hair follicle?

[youngin]

As usual scientists and doctors are just coming up with treatments, not cures. Oh it must be too much DHT, lets block it all and screw with your whole endocrine system. Oh its PGD2, lets figure out howto block it. The problem is in the follicle. Why cant someone just figure this shit out. We don't have the technology to accurately compare 2 hair follicles?