-
Does finasteride block dht or cause the body to produce less dht?
I have been on finasteride now for about a year, though I lowered my dosage to .05mg about 4 months ago when the sides were getting bad. Things have improved slightly since then. I have read that finasteride is only in the system for a matter of hours and in that time it blocks dht production. What I am curious about is why it takes a matter of months to see improvement from side effects were one to stop taking the drug? If it takes months this leads me to believe that not only does finasteride block dht when taken it also causes the body to produce less dht whilst on the drug. Am I correct in assuming this? Blocking dht and causing the body to produce less dht are two different things, are they not?
-
Good question. I await a response from everyone who promotes the safety of Propecia, as I assume they wouldn't do so without knowing the answer.
-
![Quote](https://www.baldtruthtalk.com/images/misc/quote_icon.png) Originally Posted by chrisis
Good question. I await a response from everyone who promotes the safety of Propecia, as I assume they wouldn't do so without knowing the answer.
By the same token, you rail against the dangers so shouldn't you know the answer to this yourself. If you do, just answer the question without the diatribe and passive aggressive attacks.
-
![Quote](https://www.baldtruthtalk.com/images/misc/quote_icon.png) Originally Posted by MackJames
By the same token, you rail against the dangers so shouldn't you know the answer to this yourself. If you do, just answer the question without the diatribe and passive aggressive attacks.
If describing my experience with finasteride openly and honestly is "railing against the dangers" then yeah, I rail.
Also, the onus is on the drug pusher to prove its safety, not the patient or victim. That's why we have clinical trials. The fact Merck and the FDA have been backtracking recently is cause for concern. Clearly not enough is known about how finasteride interacts with the male hormonal system resulting in side effects in an unknown number of men. I believe finasteride promoters ought to act with conscience and consider that fact, and I believe more investigations are needed.
I maintain that questions like this should be answered by those who promote the safety of finasteride. The brutal fact is no one knows why there are so many reports of side effects and why there's so much variation in terms of when they kick in, whether they're temporary or permanent and the degree of severity. This is undeniably a matter of great concern for all of us.
-
Senior Member
![Quote](https://www.baldtruthtalk.com/images/misc/quote_icon.png) Originally Posted by chrisis
If describing my experience with finasteride openly and honestly is "railing against the dangers" then yeah, I rail.
Also, the onus is on the drug pusher to prove its safety, not the patient or victim. That's why we have clinical trials. The fact Merck and the FDA have been backtracking recently is cause for concern. Clearly not enough is known about how finasteride interacts with the male hormonal system resulting in side effects in an unknown number of men. I believe finasteride promoters ought to act with conscience and consider that fact, and I believe more investigations are needed.
I maintain that questions like this should be answered by those who promote the safety of finasteride. The brutal fact is no one knows why there are so many reports of side effects and why there's so much variation in terms of when they kick in, whether they're temporary or permanent and the degree of severity. This is undeniably a matter of great concern for all of us.
Once again, I agree. Hormones have so many feedback loops based around various levels of the hormones themselves and other compounds. The endocrine system is so ridiculously complicated that it damn near defies reason. If people would be a little more critical of finasteride and admit "Okay, so it is a little bad," there could be a lot more research into what levels actually cause variations in symptoms and the particular feedback loops and levels could be controlled for.
Unrestrained defense of a drug is not a good way to handle things.
-
thanks davey for your response--unfortunately what is still unclear is how the body seems to change when on finasteride, i.e., the whole question of why it takes months to get sides to go away (if they do go away at all). clearly there is too little information. i am not a finasteride basher--i, like many of us on this forum, want to know as much as possible about the substances i put into my body to combat hairloss. i do wish the fda would be more forthcoming with finasteride's potential "dark side."
-
And for those who think side effect reports are constrained to these forums.
You're wrong
-
![Quote](https://www.baldtruthtalk.com/images/misc/quote_icon.png) Originally Posted by chrisis
Also, the onus is on the drug pusher to prove its safety, not the patient or victim.
But since finasteride did pass the required safety protocols of those clinical trials, the onus is really now upon those who claim it is unsafe to prove their case.
-
![Quote](https://www.baldtruthtalk.com/images/misc/quote_icon.png) Originally Posted by gmonasco
But since finasteride did pass the required safety protocols of those clinical trials, the onus is really now upon those who claim it is unsafe to prove their case.
Never heard of Accutane?
In 2009, Roche decided to pull Accutane off the US market after juries had awarded millions of dollars in damages to former Accutane users over inflammatory bowel disease claims. Among others, actor James Marshall sued Roche for $11 million in damages over Accutane-related disease that resulted in removal of his colon.
Accutane was cleared by the FDA, until people started killing themselves and reporting depression.
I got this from elsewhere and I can't improve on the wording so I quote:
"Don't take something as gospel just because "science" tested it and the FDA approved it. Scientists can lie just like everyone else. The FDA isn't some superhuman infallible agency. Biotechnology is INCREDIBLY competitive and a huge portion of companies are living month to month and/or barely making it on angel funding. The pressure to prove efficacy and publish good results can be incredible. I admire your faith and I do think the FDA does a good job. But blind faith will kill you."
-
Senior Member
![Quote](https://www.baldtruthtalk.com/images/misc/quote_icon.png) Originally Posted by philippe
I have been on finasteride now for about a year, though I lowered my dosage to .05mg about 4 months ago when the sides were getting bad. Things have improved slightly since then. I have read that finasteride is only in the system for a matter of hours and in that time it blocks dht production. What I am curious about is why it takes a matter of months to see improvement from side effects were one to stop taking the drug? If it takes months this leads me to believe that not only does finasteride block dht when taken it also causes the body to produce less dht whilst on the drug. Am I correct in assuming this? Blocking dht and causing the body to produce less dht are two different things, are they not?
The body does not produce DHT directly, really. Basically, testosterone in your bloodstream is binded to a substance that prevents it's breakdown. This allows testosterone to get to androgen receptors in a functional state. Once unbinded though (as it must be to bind to receptor sites and enzymes), substances can convert testosterone into other hormones. You're probably familiar with the fact that test converts to estrogen. It also converts to DHT though, once combined with a particular enzyme. Fin, however, is more competative in reacting with this enzyme. Thus, fin sort of uses up all of that substance by binding with it instead of test, allowing testosterone to remain as testosterone. It doesn't do anything to DHT itself.
So the answer to your question is that yes, those are different processes. Fin does the stop production one.
(A substance that "blocked" DHT would instead be more competative in binding with the receptor site. But as the site in question is the androgen receptor site, I'd imagine blocking that would be bad news bears even harder than fin is already sometimes bad news bears.)
Similar Threads
-
By Della in forum Women's Hair Loss: Start Your Own Topic
Replies: 7
Last Post: 11-02-2011, 08:20 AM
-
By jonnykino in forum Men's Hair Loss: Start Your Own Topic
Replies: 12
Last Post: 10-12-2011, 01:22 PM
-
By abusername in forum Hair Loss Treatments
Replies: 12
Last Post: 07-01-2011, 12:00 PM
-
By UK Boy in forum Cutting Edge / Future Treatments
Replies: 5
Last Post: 05-13-2011, 11:28 AM
-
By SE19 in forum Men's Hair Loss: Start Your Own Topic
Replies: 4
Last Post: 03-15-2011, 03:41 AM
Tags for this Thread
Posting Permissions
- You may not post new threads
- You may not post replies
- You may not post attachments
- You may not edit your posts
Forum Rules
|
» IAHRS
» The Bald Truth
» americanhairloss.org
|
Bookmarks