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Thread: bimatoprost

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  1. #19
    Junior Member
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    Apr 2013
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    Also, this may be of interest:

    "Prostaglandin E2 induces fibroblast growth factor 9 via EP3-dependent protein kinase Cdelta and Elk-1 signaling."

    http://www.ncbi.nlm.nih.gov/pubmed/16982695

    So it seems there is a link between PGE2 and FGF9, which could be interesting for those following these two strands of research. Now I don't know if this relationship is sufficient to induce the kind of feedback signaling that Cotsarelis describes in his article in Nature as being necessary to instigate follicular neogenesis, but it seems to me that the main thing coming out of that article is that they need to introduce some chemical that either induces FGF9 production or mimics FGF9 (similar to how bimatoprost is a PGE2 analogue and not PGE2 itself) that they can introduce during the wounding process. They used some chemical to induce FGF9 production in mice during the studies reported in the Nature article, so either that chemical, or perhaps a PGE2 analogue. Or maybe just the PGE2 analogue could play an important role in FGF9 production without other processes.

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