Replicel

[bigentries]

That's probably a simplistic estimate, as DHT production is not constant over the course of a lifetime.

And its still a mistery how to quantify the damage caused by DHT, considering that the majority of people start balding after the end of puberty

[stillinHS1994]

And its still a mistery how to quantify the damage caused by DHT, considering that the majority of people start balding after the end of puberty

Or you can start in late puberty...like me... Ugh ...thanks for them genes mom and dad

[Maradona]

Haters gon' Hate

Right, because the only thing stopping those other companies from getting to market sooner is that they're all just lollygagging around, waiting for a competitor to spur them into hurrying up.

doesn't histogen and aderans have a potent formula already? they just want to improve their product, if replicel shows high results, other companies will release and go to phase 2,3 without delays with whatever they had and improve their results at the same time.

or should they wait 10/15 years until they get 100% results and replicel/follica is already at your local store?

One product is sure to dominate the market if it's fairly effective and comes first.

[Pate]

Yeah my understanding is that Histogen hair will last as long as your original hair before you started balding. Do if you started balding at 30 you get another 30 years. Im sure by then none of this will matter and entirely new and different options will be available.

So who cares if Histogen hair isnt truly permament :P

The 30 year thing is what Gail Naughton said in one of her interviews but as a couple of other guys have pointed out, there are some problems with that argument:

1. You don't go through baldness until adolesence. So if you start balding at 25 and hit puberty at 15 that's only 10 years. Which is still great but... Problem #2 is a bit more of an issue.

2. It's not just a case of cumulative DHT exposure. The mechanism of DHT damage is not fully understood but seems to involve age somehow. If you stop taking Propecia you experience 'catch-up baldness' even though your follicles have been exposed to much less DHT over the time you took Propecia. If cumulative DHT exposure was the only cause, you wouldn't experience catch-up baldness, you'd just start balding again where you left off at the same rate you were balding before. It's like there's some sort of body clock running independently of DHT, and when the DHT levels return to normal, you 'fast-forward' straight to where you are on the clock.

So I think realistically we just have no idea how long Histogen will last and there's only one way to find out - conduct the trials and wait and see.

But even if it only lasts two years, I don't even care. I would sit through a series of injections every two years if it restored me my flowing locks.

[Losing_It]

2. It's not just a case of cumulative DHT exposure. The mechanism of DHT damage is not fully understood but seems to involve age somehow. If you stop taking Propecia you experience 'catch-up baldness' even though your follicles have been exposed to much less DHT over the time you took Propecia. If cumulative DHT exposure was the only cause, you wouldn't experience catch-up baldness, you'd just start balding again where you left off at the same rate you were balding before. It's like there's some sort of body clock running independently of DHT, and when the DHT levels return to normal, you 'fast-forward' straight to where you are on the clock.

I often wonder about this. Surely, it must relate to the aggresiveness of a person's hairloss. I understand that you lose what you gained within a year of stopping treatment, but surely you can't go from 3 to 5 within a year, especially if you taken fin for say ten years? IDK maybe I am just confused. Anyways hope replicel works out for all of us, even if it stops further progression.

[67mph]

Kinda close now aren't we, phase 1 results to be announced (more than what they've given us thus far) end of March, phase 2 about to be underway, everyone holding tight til then?, i feel the thread's gone of the boil some what.

If any of you, like me, have seen the amount of good things coming out in the news regarding Stem Cells being used in all manner of human 'improvements', you'll see why i am actually excited by Replicel sorting us lot out.

Though, on a downlow, it wouldn't be for atleast 10 years for the average jo to have this new advancement done due to the legalities, money and of course the queue.

good luck you lot, regards,
57mph

[2020]

10 years? really? Both Histogen and Replicel claim that they will release their treatments in 2015.

[67mph]

i know i know sorry, but that's just me saying it, the classic 10 years sorry.

What i meant was -
released in 2015 (4 years away if end of 2015)
cash to get the treament (say 4 years saving)
balls to go ahead and get it done when you've the cash (12 months thought process)

umm, ok lets opt for 9 years, that ok?

You may have to update your profile name by then 2020, haa!

regrads,
57mph

[Follicle Death Row]

10 years? really? Both Histogen and Replicel claim that they will release their treatments in 2015.

As much as it pains me to say it there's zero chance of either being out in 2015.

So many hoops to jump through. Actually that's not fair, they have to go through all these checks.

[2020]

As much as it pains me to say it there's zero chance of either being out in 2015.

So many hoops to jump through. Actually that's not fair, they have to go through all these checks.

you do realize that investors too are pressuring them to release their treatment as soon as possible so that they can make their money back. It's in the best interest for those companies to work as fast as possible.
btw, Replicel has been working on this for the past 9 years. I'm sure they're very close by now.
We already know that Histogen stuff works, the rest is just tweaking and maximizing results...

[gmonasco]

you do realize that investors too are pressuring them to release their treatment as soon as possible so that they can make their money back. It's in the best interest for those companies to work as fast as possible.

The process takes as long as it takes. Nobody is served by releasing a product before it's ready.

btw, Replicel has been working on this for the past 9 years. I'm sure they're very close by now.

People have been working on a whole lot of cures for much longer than that, without success.

We already know that Histogen stuff works, the rest is just tweaking and maximizing results...

Actually, "we" know no such thing.

[2020]

Actually, "we" know no such thing.

http://histogen.com/aboutus/news_events.htm#25

[gmonasco]

Those of us who actually know how to interpret data understand the difference between "here are some preliminary results that might possibly indicate we have something" and "it works."

[2020]

Those of us who actually know how to interpret data understand the difference between "here are some preliminary results that might possibly indicate we have something" and "it works."

but they already tested it on humans and it worked. Do you see the percentages?

[gmonasco]

Yes, and those percentages don't demonstrate in themselves that Histogen's HSC actually creates any new hairs at all. For all that one can tell from the data, HSC might simply be coaxing existing hairs out of the catagen/telogen phase early.