CB-03-01 - new antiandrogenic

[BaldingJugZ]

Anyone ever heard of a supposed new anti-androgenic drug called CB-03-01?

I've looked into it and read a few threads on the subject.

Apparently, it is still in the next phase of testing. However, there is a few Chinese labs producing it at a hefty price.

So, was just wondering if anyone has bought it from China and how they went about getting it into a topical solution? (as it's in crystal form)

Any thoughts on it?

[mlao]

At this stage I think it's a bad idea. All those guys on *** and HLH never post a lot of pictures of their success on things like RU58841. Now they are trying to go in on a group buy for CB-03-01 from the same labs that they buy the RU from.
Don't get me wrong I hope it works and they show great results but even Cosmos the company that owns the patent and is doing the clinical trials hasn't released any photo evidence of results. Nor is there an established method on how to use it. I would wait.

[Kirby_]

Update from Cosmo.

http://www.cosmopharma.com/~/media/F...25JAN13_v5.pdf

[Thinning87]

very interesting, this would be a topical application and wouldn't affect the 5 alpha reductase, in that way causing less side effects (correct me if I'm wrong)

[NotBelievingIt]

very interesting, this would be a topical application and wouldn't affect the 5 alpha reductase, in that way causing less side effects (correct me if I'm wrong)

Nope, you read that correctly. What it reads like it does is binds to the androgen receptors in hair follicile where it is applied, thereby basically taking the place of DHT on the hair follicile.

Fin/Dut bind with 5AR and prevent that enzyme from converting T to DHT, hence side effects. This basically does the same thing, but bypasses the hormone altering.

Who knows what side effects it might have. Your hair might stop falling out, but it might degrade hair quality if active androgen receptors are decreased, thereby decreasing potential protein uptake....

Something interesting to follow.

[Thinning87]

yeah, or virtually this may be a cure in the sense that if it doesn't have side effects it would pretty much save all the hair or highly slow down MPB.

I see some people were getting some shipped from China, these people are in very early stages of development so I definitely wouldn't try it!

[burtandernie]

Interesting for all the different timelines people say their projection is early 2015 to be on the market if all goes well. Also for all the talk about vehicles they mention the vehicle they are looking at for the 5% cream.
Nothing is ever certain with this stuff, but I doubt the androgen receptors interact with proteins uptake. They say this chemical gets converted into a natural substance in the blood stream so it seems like sides will be pretty minimal, but again its unpredictable in nature given how complicated this all is.

[35YrsAfter]

Update from Cosmo.

http://www.cosmopharma.com/~/media/F...25JAN13_v5.pdf

Thanks for posting. I believe that treatments more effective than Propecia and Avodart will be available within the next few years.

35YrsAfter also posts as CITNews and works at Dr. Cole's office - forhair.com - Cole Hair Transplant 1070 Powers Place Alpharetta, Georgia 30009 - Phone 678-566-1011 - email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice. Please feel free to call or email me with any questions. Ask for Chuck

[FearTheLoss]

Thanks for posting. I believe that treatments more effective than Propecia and Avodart will be available within the next few years.

35YrsAfter also posts as CITNews and works at Dr. Cole's office - forhair.com - Cole Hair Transplant 1070 Powers Place Alpharetta, Georgia 30009 - Phone 678-566-1011 - email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice. Please feel free to call or email me with any questions. Ask for Chuck

Correct me if I'm wrong, but they finish POC in March of 2015, so we could see this hit the market by the end of 2016, baring they get the results they want in POC.

CB won't need a phase IIb? Also, this could be released overseas in 2015?

[sdsurfin]

How did the acne product go so fast from IND to phase II? If you look at the alopecia product, the timeline goes from IND to a long time in proof of concept. Is proff of concept the same as phase II or I? Either way I'm not sure why people are saying 3-5 years, it seems more like 2 more for phase 1, another 2 probably for phase 2, and maybe another for phase 3, and then putting it out to market after that. 6-8 seems more realistic. And that's if this BS even works, they compare it to flutamide on here, didn't people try that with no success? Also, I doubt there's any great mystery to the vehicle, they are just using anhydrous solution, I'm sure if this was really a bette treatment than propecia then people would have seen results by now. Wouldnt put my hopes on this stuff.