Histogen Update - Spencer Kobren Speaks With Dr. Craig L. Ziering

[RichardDawkins]

I have to agree...... Didnt you listen to the interview

[reset]

Thanks for the interview Spencer. It`s great we`re able to hear directly from the guys in the field. I don`t know if any one at Histogen is taking taking questions now, but I`ve heard about `Pan-Asian` trials but aside from Singapore I haven`t heard of any other countries in Asia taking part in the trials. Which, if any, other countries are going to take part in the trials? Thanks.

[CVAZBAR]

Right now Singapore but possibly Korea as well.

I know you spoke about the 2 year trials so far and how hairs were still present after that time. If histogen does not do much as far as growth for some, will it at least guarantee no further hair loss? Did you notice this in pre trials?

[reset]

Right now Singapore but possibly Korea as well.

Thanks for answering my question. Don`t mind the negative posts. A lot of anger/frustration over losing hair sometimes translates to negative posts. I hope you`ll be able to keep us apprised of new developments.

On a side note, Singapore has transformed itself as the leading bio-tech hub in Asia and among the top hubs across the entire globe. Seems no coincidence Histogen chose Singapore as a place to conduct trials. Some links for anyone that`s interested.

http://www.massdevice.com/blogs/nik-...o-science-hubs

http://www.channelnewsasia.com/stori...106583/1/.html

http://www.outsourcing-pharma.com/Cl...linical-trials

[blowmeup]

Great post reset! We’re all bitter about losing our hair, but I could never understand why some guys try to take it out on these forums. It only detracts from the point and it’s obnoxious.

[gmonasco]

Didnt you listen to the interview

Yes, I did. Didn't you read my post? I could hardly have said I found it lacking in detail if I hadn't listened to it.

As I said, there was lots of happy noise about what Histogen might do, but precious little solid info about what it has actually proved to do so far.

[RichardDawkins]

But right now there isnt much else to say they did test if HSC could be dangerous, and it isnt.

They saw hair still be there after two years and now they gonna for different approches after 6 weeks etc which is exactly according to plan.

I dont think that it was all happy talk, it was a realistic observation from someone at the source.

The most important thing is, its safe AND the hair stays, who knows what can be achieved with higher injections here and there. At least from the data it could hairtransplants make more sufficient with less grafts to plant.

Also the idea about Histogen in the first round to stop hairloss and grow back special parts and then go for Acell orientated hair transplant is pretty damn good.

[gmonasco]

But right now there isnt much else to say

My point exactly. No substantive information is not exactly something to be optimistic about.

it was a realistic observation from someone at the source

But someone who also has a vested interest in making things seem as positive as possible.

The most important thing is, its safe AND the hair stays

Neither of those factors has been established yet.

First of all, early stage clinical trials seek to determine whether a particular treatment manifests any immediately obvious deleterious effects serious enough to warrant discontinuation of the trials. If if doesn't, then the trials can proceed, but that milestone is very far from demonstrating that a treatment is "safe" in an overall sense. Safety is something which can only be determined with much wider trials, a much larger user base, and the passage of time (as numerous recalls of previously approved drugs have demonstrated).

Second, any trial of a treatment for regrowing hair would realistically have run at least two years (and possibly longer) just to determine whether the new hairs produced by the treatment survive an anagen/telogen cycle. Even then, you don't know for sure -- a newly produced hair might survive the first cycle, but that's no guarantee it won't, say, (akin to miniaturization) grow progressively weaker and fail to survive subsequent cycles. What the long term benefits or effects will be are something that can only be determined in the long term, and obviously none of us here is going to be able to wait a couple of lifetimes to verrify how things pan out.

[CVAZBAR]

My point exactly. No substantive information is not exactly something to be optimistic about.



But someone who also has a vested interest in making things seem as positive as possible.



Neither of those factors has been established yet.

First of all, early stage clinical trials seek to determine whether a particular treatment manifests any immediately obvious deleterious effects serious enough to warrant discontinuation of the trials. If if doesn't, then the trials can proceed, but that milestone is very far from demonstrating that a treatment is "safe" in an overall sense. Safety is something which can only be determined with much wider trials, a much larger user base, and the passage of time (as numerous recalls of previously approved drugs have demonstrated).

Second, any trial of a treatment for regrowing hair would realistically have run at least two years (and possibly longer) just to determine whether the new hairs produced by the treatment survive an anagen/telogen cycle. Even then, you don't know for sure -- a newly produced hair might survive the first cycle, but that's no guarantee it won't, say, (akin to miniaturization) grow progressively weaker and fail to survive subsequent cycles. What the long term benefits or effects will be are something that can only be determined in the long term, and obviously none of us here is going to be able to wait a couple of lifetimes to verrify how things pan out.

Well if you already knew all the answers, why are you disappointed? I doubt you will have to wait a LIFETIME homie so don't worry about that ha. So what if the hair wont survive the cycle? If it grew it in the first place, then get another injection. I think its pretty obvious that we still don't know shit about it but i do know we wont have to wait a couple of lifetimes to find out. We will know soon enough.

[gmonasco]

Well if you already knew all the answers, why are you disappointed? I doubt you will have to wait a LIFETIME homie so don't worry about that ha. So what if the hair wont survive the cycle? If it grew it in the first place, then get another injection. I think its pretty obvious that we still don't know shit about it but i do know we wont have to wait a couple of lifetimes to find out. We will know soon enough.

You might find this system works best if you actually take the time to read and comprehend material prior to responding to it.