Histogen Update - Spencer Kobren Speaks With Dr. Craig L. Ziering

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  • KeepHoping
    Senior Member
    • Dec 2010
    • 182

    I asked if they had started the trail and this was the response:

    "In response to your further questions, all 55 subjects have been enrolled and injected in the Phase I/II clinical trial of HSC, and that trial is currently in progress.

    Best,
    Eileen"

    And in an earlier email she said:

    "Thank you for your interest and message. Please excuse the delay in my response, we are working through a large number of inquiries. In response to your question, the mechanism of action of HSC indicates that the complex both stimulates existing follicles to produce new hairs as well as triggers stem cells in the scalp to become new hair follicles. Details from the pilot trial of HSC can be found on our website, and we look forward to sharing data from the Phase I/II trial in the coming months."

    Comment

    • sausage
      Senior Member
      • Jan 2012
      • 1064

      Originally posted by KeepHoping
      I asked if they had started the trail and this was the response:

      "In response to your further questions, all 55 subjects have been enrolled and injected in the Phase I/II clinical trial of HSC, and that trial is currently in progress.

      Best,
      Eileen"

      And in an earlier email she said:

      "Thank you for your interest and message. Please excuse the delay in my response, we are working through a large number of inquiries. In response to your question, the mechanism of action of HSC indicates that the complex both stimulates existing follicles to produce new hairs as well as triggers stem cells in the scalp to become new hair follicles. Details from the pilot trial of HSC can be found on our website, and we look forward to sharing data from the Phase I/II trial in the coming months."

      How long do they wait to see growth? I bet they must wait a year and study every guinea pigs heads after that time even if say 80% of them grow hair in the first month they probably wait to see if it lasts and also wait to see if growth eventually happens in the other 20%.

      So I guess the trials take a year at a time?

      Comment

      • Pate
        Senior Member
        • Sep 2011
        • 427

        Originally posted by sausage
        How long do they wait to see growth? I bet they must wait a year and study every guinea pigs heads after that time even if say 80% of them grow hair in the first month they probably wait to see if it lasts and also wait to see if growth eventually happens in the other 20%.

        So I guess the trials take a year at a time?
        Last time they released initial results at 3 months, then 5 months, then 12 months.

        The growth was fair at 3 months, then slipped a bit at 5 months, and it was looking like HSC wasn't long term.

        But then at 12 months the results were even better than at 3 months. So it looks like the 5 months was just the new growth cycling before coming back stronger.

        If you really want to know all about the last trial, click on the link to their scientific paper published in the dermatology journal and buy a copy of it. Or alternatively find somebody with online journal access (a university student or researcher) and get them to get a copy of it for free.

        Comment

        • UK_
          Senior Member
          • Feb 2011
          • 2744

          Originally posted by Pate
          But then at 12 months the results were even better than at 3 months. So it looks like the 5 months was just the new growth cycling before coming back stronger.

          If you really want to know all about the last trial, click on the link to their scientific paper published in the dermatology journal and buy a copy of it. Or alternatively find somebody with online journal access (a university student or researcher) and get them to get a copy of it for free.
          Yeah that 12 month peak was really promising, it showed that the HSC had a lasting impact on the actual growth cycle, im glad to hear of them communicating with the public, its nice of them and we should all appreciate that. It is also great to hear that they've been cracking on with Phase I/II.

          Thanks for posting up the email KeepHoping.

          Comment

          • sausage
            Senior Member
            • Jan 2012
            • 1064

            Does anyone know if those people still have the new hair that grew during those tests?

            Do they still have that hair today?

            Comment

            • KeepHoping
              Senior Member
              • Dec 2010
              • 182

              No problem guys, keep your fingers crossed a lot of good things are coming.

              Comment

              • 2020
                Senior Member
                • Jan 2012
                • 1527

                Originally posted by KeepHoping
                No problem guys, keep your fingers crossed a lot of good things are coming.
                is that sarcasm?

                Comment

                • NeedHairASAP
                  Senior Member
                  • Jul 2011
                  • 1410

                  this thread is a bunch of useless guessing, people fighting, and people saying, "come on guys were all in this together blah blah blah"

                  Comment

                  • UK Boy
                    Senior Member
                    • Apr 2011
                    • 244

                    Originally posted by NeedHairASAP
                    this thread is a bunch of useless guessing, people fighting, and people saying, "come on guys were all in this together blah blah blah"
                    There was no guessing about what I stated in my post. If you go on the clinical trials website it's there in black and white and backed up by the email from Histogen - they have def started there phase I/II trial!

                    I agree that it's annoying to come on here and read a whole string of posts that have no truth or evidence behind them and are just people speculating but your coment is posted at a time when what has been discusssed is actual FACT not speculation.

                    This is good news, it means the trial should be finished by Dec 2012 /Jan 2013 and hopefully (now that their legal issues are out of the way) Histogen will be able to move on promtly thereafter. I know to some this isn't a huge thing because it's still gonna be years before it's released but considering that some though Histogen died back in mid 2011 then it is a big deal - they didn't die and they're moving forward with trials.

                    Comment

                    • KeepHoping
                      Senior Member
                      • Dec 2010
                      • 182

                      It's not sarcasm at all, I honestly believe that there will be new options for hairloss soon, within 2012 or next year we may have bimatoprost for the scalp and things to help enhance growth and stop the progression until better treatments arrive in 2013/2014. If you think about it, this is in fact a race for these companies, the first to come up with a solution will become billionaires pretty quickly, the incentive for them to get their products to the market is VERY high and they know that, all the negative chatter is a waste of time and helps nobody. Histogen was on the verge of shutting down and got some big investments and is moving forward, that alone is reason to stay hopeful.

                      Comment

                      • sausage
                        Senior Member
                        • Jan 2012
                        • 1064

                        They need to up these doses quicker then, get on with it, I don't have time!!!

                        Even when they do realise these products work it will probably take at least a year to get them produced on a huge scale.

                        Comment

                        • Kirby_
                          Senior Member
                          • Jan 2012
                          • 447

                          Originally posted by KeepHoping
                          It's not sarcasm at all, I honestly believe that there will be new options for hairloss soon, within 2012 or next year we may have bimatoprost for the scalp and things to help enhance growth and stop the progression until better treatments arrive in 2013/2014. If you think about it, this is in fact a race for these companies, the first to come up with a solution will become billionaires pretty quickly, the incentive for them to get their products to the market is VERY high and they know that, all the negative chatter is a waste of time and helps nobody. Histogen was on the verge of shutting down and got some big investments and is moving forward, that alone is reason to stay hopeful.
                          This.

                          Let's stay hopeful (even if some treatments all by the wayside, at least one or more will emerge on the market) and above all solidaristic, we're all in the same balding boat after all.

                          Comment

                          • sausage
                            Senior Member
                            • Jan 2012
                            • 1064

                            If a cure comes out we should all meet up in trafalgar square and celebrate.

                            Comment

                            • Kirby_
                              Senior Member
                              • Jan 2012
                              • 447

                              Originally posted by sausage
                              If a cure comes out we should all meet up in trafalgar square and celebrate.
                              With plenty of alcoholic drinks.

                              Comment

                              • Follicle Death Row
                                Senior Member
                                • May 2011
                                • 1066

                                Originally posted by sausage
                                If a cure comes out we should all meet up in trafalgar square and celebrate.
                                I'd up for that.

                                Comment

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