Histogen Update - Spencer Kobren Speaks With Dr. Craig L. Ziering

[tizzle]

thx a lot Pate! sounds very promising considering in the second trial they are going to inject more HSC. I cant wait to see the results

[2020]

Okay, so. In order to stop these figures flying back and forth all over BTT and the other forums... I have bought the Histogen paper published in the JDD and linked to on their website. Cost 15 USD for a one-time purchase. Unfortunately I am not a student any more I would have free access to journals like these through my university but oh well, 15 USD is a small price to pay.

you bought this?
http://www.************/hair-loss/im...879_file54.pdf

hairsite already had it apparently....


those numbers you're giving us are only from TWO subjects. If you want the averages:

The improvements caused by HSC treatment were significantly greater than those observed in placebo-treated sites for
hair shaft thickness (6.3%±2.5% vs. -0.63%±2.1%; F=0.046),
thickness density (12.8%±4.5% vs. -0.2% ± 2.9%; P=0.028),
and terminal hair density (20.6±4.9% vs. 4.4±4.9%; P=0.029).

Although a similar trend was seen at 22 weeks, significance was lost as there was no further growth improvement in the subjects. However, at one year, we observed significant improvements in
hair count (16.0±6.6% vs. 3.65±3.7%)
and substantial increases in thickness density (17.6±8.39% vs. 0.67±4.3%),
and terminal hair density (29.5±14.8 vs. 2.4±6.8%)

^ this is all from their official paper:

http://jddonline.com/articles/dermatology/1650

EDIT: pate was right:

Subject 027 showed a 123.4% increase in total hair count at one year following a single injection of HSC

[tizzle]

Subject 027 is one lucky bastard

[BoSox]

123% ???? That's gotta be a fluke. This would be incredible if they can get results like this consistently.

[gmonasco]

Subject 027 showed a 123.4% increase in total hair count at one year following a single injection of HSC

Eh? Where does this figure come from?

[2020]

Eh? Where does this figure come from?

from this:
http://www.************/hair-loss/im...879_file54.pdf

page 3

[gmonasco]

from this: page 3

But if you look at the figure referenced in that note, it shows photos displaying a hair count going from a baseline of 214.5 hairs to 324.5 hairs after one year, which is only a 51.2% increase.

[jpm]

With growth rates like this, I and many other are probably thinking, sod the healthy and safety trials. Pump industrial quantities of that sweet sweet HSC into my scalp please


.......only kidding, health and safety first guys!!

[jpm]

Just reading through the Histogen article and it states, 'HSC's effect on hair growth was concentrated within 1-2mm of the site of injection'.

I read somewhere that it spread out once injected...otherwise you would need hundreds of injections. ouch!

[LarryDavid]

Why is the haircount increasing in the placebo group?
Even when you look at the average of all subjects it is increasing after one year.

[tizzle]

I read somewhere that it spread out once injected...otherwise you would need hundreds of injections. ouch!

i would take a thousand needles as long as i get my hair back

[jpm]

Why is the haircount increasing in the placebo group?
Even when you look at the average of all subjects it is increasing after one year.

I'm curious about this too!

[tizzle]

maybe there were many hair follicles which went from resting to growing phase (sorry i dont know the scientific terms)

I read a study once (i think it was a Fin Study) where i saw the same thing

[WillhasWill]

Why is the haircount increasing in the placebo group?
Even when you look at the average of all subjects it is increasing after one year.

It almost shows that there is a tendency to be over generous. Human error still occurs I'd imagine when counting hairs and when your conducting a study into a treatment for hairloss, you'll always want to see more hairs. But the people conducting the study do not know who had the real injection or placebo.

[bigentries]

The hair count increasing in the placebo group is probably a mixture of margin of error and the nature of the hair cycle