How might flutamide treat androgenetic alopecia
Flutamide is the generic name for the commercial brand name drugs Euflex and Eulexin by Schering. Flutamide comes as 250mg oral tablets.
Flutamide is a non-steroidal antiandrogen which inhibits androgen uptake. Flutamide also stops androgens from binding to receptors in the nuclei of cells. Flutamide is used to treat a variety of androgen influenced diseases such as prostate carcinomas, hirsutism, acne, and alopecia. As an antiandrogen oral flutamide has been used to treat female androgenetic alopecia, but only one or two published studies on its effectiveness are available. One study involved treating women with hirsutism, acne, or alopecia. The investigators reported an 80% success rate for women with acne of alopecia when treated with flutamide. They reported that Flutamide was significantly superior to Spironolactone for treating androgen dependant conditions in women. There are several studies on the use of flutamide to treat androgen dependent hirsutism in women and all suggest moderate to good success rates.
Another study looked at the efficacy of topically applied flutamide versus finasteride in human bladnig sclpa skin grafted onto mice. The researchers observed that flutamide was better than finasteride in terms of promoting hair growth. From this study it may be possible for men to use topical flutamide and avoid the systemic side effects that men develop when taking the drug orally.
How might flutamide treat androgenetic alopecia references
Luthy I, Caron S, Belanger A, Labrie F. Effects of flutamide, a pure antiandrogen, on endocrine parameters, in the adult female rat. Gynecol Endocrinol. 1987 Jun;1(2):151-68.
Cusan L, Dupont A, Gomez JL, Tremblay RR, Labrie F. Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial. Fertil Steril. 1994 Feb;61(2):281-7.
Sintov A, Serafimovich S, Gilhar A. New topical antiandrogenic formulations can stimulate hair growth in human bald scalp grafted onto mice. Int J Pharm. 2000 Jan 20;194(1):125-34.
Singh SM, Gauthier S, Labrie F. Androgen receptor antagonists (antiandrogens): structure-activity relationships. Curr Med Chem. 2000 Feb;7(2):211-47.
Muderris II, Bayram F, Sahin Y, Kelestimur F, Tutus A, Ayata D. The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism. Fertil Steril. 1996 Aug;66(2):220-2.
Marcondes JA, Minnani SL, Luthold WW, Wajchenberg BL, Samojlik E, Kirschner MA. Treatment of hirsutism in women with flutamide. Fertil Steril. 1992 Mar;57(3):543-7.
Flutamide is the generic name for the commercial brand name drugs Euflex and Eulexin by Schering. Flutamide comes as 250mg oral tablets.
Flutamide is a non-steroidal antiandrogen which inhibits androgen uptake. Flutamide also stops androgens from binding to receptors in the nuclei of cells. Flutamide is used to treat a variety of androgen influenced diseases such as prostate carcinomas, hirsutism, acne, and alopecia. As an antiandrogen oral flutamide has been used to treat female androgenetic alopecia, but only one or two published studies on its effectiveness are available. One study involved treating women with hirsutism, acne, or alopecia. The investigators reported an 80% success rate for women with acne of alopecia when treated with flutamide. They reported that Flutamide was significantly superior to Spironolactone for treating androgen dependant conditions in women. There are several studies on the use of flutamide to treat androgen dependent hirsutism in women and all suggest moderate to good success rates.
Another study looked at the efficacy of topically applied flutamide versus finasteride in human bladnig sclpa skin grafted onto mice. The researchers observed that flutamide was better than finasteride in terms of promoting hair growth. From this study it may be possible for men to use topical flutamide and avoid the systemic side effects that men develop when taking the drug orally.
How might flutamide treat androgenetic alopecia references
Luthy I, Caron S, Belanger A, Labrie F. Effects of flutamide, a pure antiandrogen, on endocrine parameters, in the adult female rat. Gynecol Endocrinol. 1987 Jun;1(2):151-68.
Cusan L, Dupont A, Gomez JL, Tremblay RR, Labrie F. Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial. Fertil Steril. 1994 Feb;61(2):281-7.
Sintov A, Serafimovich S, Gilhar A. New topical antiandrogenic formulations can stimulate hair growth in human bald scalp grafted onto mice. Int J Pharm. 2000 Jan 20;194(1):125-34.
Singh SM, Gauthier S, Labrie F. Androgen receptor antagonists (antiandrogens): structure-activity relationships. Curr Med Chem. 2000 Feb;7(2):211-47.
Muderris II, Bayram F, Sahin Y, Kelestimur F, Tutus A, Ayata D. The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism. Fertil Steril. 1996 Aug;66(2):220-2.
Marcondes JA, Minnani SL, Luthold WW, Wajchenberg BL, Samojlik E, Kirschner MA. Treatment of hirsutism in women with flutamide. Fertil Steril. 1992 Mar;57(3):543-7.
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