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hello guysl
so for approx 3 months I've been putting a decent amount of research into propecia dutasteride etc
what really frustrated with mt about propecia is that despite its high success rate 83-90% i didn't know why it worked for some and not others well now I'm fairly confident i know why
essentially people who suffer from mpb have hair follicles that are sensitive to dht. This is the cause of MPB. Propecia works by inhibiting the production of dht by around 70%. This figure varies from person to person but very little (61-75%). Therefore as there is less dht then less attacks the dht sensitive hair follicles preventing further MPB giving the 83-90% figure.
Now for regrowth. A lot is to be said for propecia producing regrowth in younger patients more so than older. Although this may be due to younger bodies being able to metabolise drugs more effectively than older people the main reason regrowth is seen more so in younger patients is because the hair loss is more recent. Therefore the hair follicles are not yet dead and have went through less damage by dht. Therefore by lowering dht concentration hair follicles that were not producing hair are able to start producing hair again. Whereas hair follicles that has been long gone are likely dead and so regrowth is unlikely.
Now to the most interesting part the 17%-10% that it dosent work for. The reason that this drug does not work for them is because despite the reduction in dht there follicles are so sensitive to dht that they continue to be attacked by the remaining dht and so the person continues to lose hair although it should be noted at a slower rate. For these people dutasteride should be considered as this reduces dht by over 90% and so hairless should essentially be stopped.
for those curious as to wether finasteride looses its effectiveness in short no it does not. If you have successfully used finasteride for years and seem to notice your hair thinning finasteride is still lowering your dht levels by 70% but your hair follicles have become mor sensitive to dht over time and so hairless will resume but at a very slow rate
So for those worrying about factors such as age or event to extent of hairloss as to wether propecia will work for you a better gauge is to think about the aggression of your hairloss. This is not dictated by your age i.e. if you started loosing hair at 16 or by how much hair you've already lost or even by how bald your male relatives are it is more dictated by how fast you lost your hair i.e. full head to NW 4 in 3 months
Yet do not despair those who have began to slowly loose after years of success on propecia or even those who have aggressive enough baldness that propecia does not work as durasteride will likely prevent any further balding no matter how aggressive your hairless becomes
Although i am aware that durasteride is not approved by the fda for MPB it has been approved in korea in 2009 and i believe recently in japan
Hope this was helpful
ozzo
so for approx 3 months I've been putting a decent amount of research into propecia dutasteride etc
what really frustrated with mt about propecia is that despite its high success rate 83-90% i didn't know why it worked for some and not others well now I'm fairly confident i know why
essentially people who suffer from mpb have hair follicles that are sensitive to dht. This is the cause of MPB. Propecia works by inhibiting the production of dht by around 70%. This figure varies from person to person but very little (61-75%). Therefore as there is less dht then less attacks the dht sensitive hair follicles preventing further MPB giving the 83-90% figure.
Now for regrowth. A lot is to be said for propecia producing regrowth in younger patients more so than older. Although this may be due to younger bodies being able to metabolise drugs more effectively than older people the main reason regrowth is seen more so in younger patients is because the hair loss is more recent. Therefore the hair follicles are not yet dead and have went through less damage by dht. Therefore by lowering dht concentration hair follicles that were not producing hair are able to start producing hair again. Whereas hair follicles that has been long gone are likely dead and so regrowth is unlikely.
Now to the most interesting part the 17%-10% that it dosent work for. The reason that this drug does not work for them is because despite the reduction in dht there follicles are so sensitive to dht that they continue to be attacked by the remaining dht and so the person continues to lose hair although it should be noted at a slower rate. For these people dutasteride should be considered as this reduces dht by over 90% and so hairless should essentially be stopped.
for those curious as to wether finasteride looses its effectiveness in short no it does not. If you have successfully used finasteride for years and seem to notice your hair thinning finasteride is still lowering your dht levels by 70% but your hair follicles have become mor sensitive to dht over time and so hairless will resume but at a very slow rate
So for those worrying about factors such as age or event to extent of hairloss as to wether propecia will work for you a better gauge is to think about the aggression of your hairloss. This is not dictated by your age i.e. if you started loosing hair at 16 or by how much hair you've already lost or even by how bald your male relatives are it is more dictated by how fast you lost your hair i.e. full head to NW 4 in 3 months
Yet do not despair those who have began to slowly loose after years of success on propecia or even those who have aggressive enough baldness that propecia does not work as durasteride will likely prevent any further balding no matter how aggressive your hairless becomes
Although i am aware that durasteride is not approved by the fda for MPB it has been approved in korea in 2009 and i believe recently in japan
Hope this was helpful
ozzo
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