+ Reply to Thread
Results 1 to 1 of 1
  1. #1
    Member
    Join Date
    May 2016
    Location
    Toronto
    Posts
    74

    Default Targeting of CXXC5 by a Competing Peptide Stimulates Hair Re-growth

    https://www.ncbi.nlm.nih.gov/pubmed/28595998

    The Wnt/β-catenin pathway has been implicated in hair follicle development and hair regeneration in adults. We discovered that CXXC-type zinc finger protein 5 (CXXC5) is a negative regulator of the Wnt/β-catenin pathway involved in hair re-growth and wound-induced hair follicle neogenesis (WIHN) via an interaction with Dishevelled (Dvl). CXXC5 was up-regulated in miniaturized hair follicles and arrector pili muscles in human balding scalps. The inhibitory effects of CXXC5 on alkaline phosphatase activity and cell proliferation were demonstrated using human hair follicle dermal papilla cells. Moreover, CXXC5-/- mice displayed accelerated hair re-growth and treatment with valproic acid, a glycogen synthase kinase 3β inhibitor that activates the Wnt/β-catenin pathway, further induced hair re-growth in the CXXC5-/- mice. Disrupting the CXXC5-Dvl interaction with a competitor peptide activated the Wnt/β-catenin pathway and accelerated hair re-growth and WIHN. Overall, these findings suggest that the CXXC5-Dvl interaction is a potential target for treatment of hair loss.

Similar Threads

  1. Replies: 7
    Last Post: 01-04-2024, 11:17 PM
  2. Replies: 6
    Last Post: 04-21-2016, 12:11 PM
  3. Can Parathyroid Hormone 7-34 stimulates hair growth?
    By sherrysherry in forum Hair Transplant: Start Your Own Topic
    Replies: 0
    Last Post: 02-29-2016, 01:31 AM
  4. HR peptide for hair loss
    By alitaher2009 in forum Cutting Edge / Future Treatments
    Replies: 5
    Last Post: 08-09-2015, 04:38 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts

» IAHRS

hair transplant surgeons

» The Bald Truth

» Recent Threads

1800 graft repair case results by Dr. Lindsey
Yesterday 08:38 AM
Last Post By Dr. Lindsey
Yesterday 08:38 AM
Navigating the German Job Market as a Kenyan Citizen
11-04-2023 06:31 AM
Last Post By Keegan212
Yesterday 03:51 AM
DR HAKAN DOGANAY/ 4500 GRAFTS / Implanter Pen+FUE
03-26-2024 04:15 PM
Last Post By Hakan Doganay, MD
03-26-2024 04:15 PM
The Mane Event for Thursday, June 15th, 2023
06-15-2023 02:59 PM
Last Post By gisecit34
03-26-2024 08:05 AM