+ Reply to Thread
Results 1 to 2 of 2
  1. #1
    Member
    Join Date
    Sep 2015
    Posts
    90

    Default This maybe why fin is not working for you?

    Found this article:

    http://www.ilht.com/mechanism-of-mal...-hair-loss.php

    It says there are two pathways, one requires 5AR enzymes, and alternate pathway that does not involved 5AR enzymes, that explains why fin/dut may not be effective on some people.

    This is worrying! Does this alternate pathway happen to everyone? Or just some people? I don't understand, how does testosterone get converted to DHT with just blood circulation?


    From the article:

    Alternate pathways

    Testosterone can get converted into DHT in the blood circulation. The circulating DHT in the blood enter in the tissues including scalp tissue. In the scalp tissue DHT enter into hair follicle cells, mainly the papilla cells, outer root sheath cells and sebaceous gland cells. DHT might bind to different receptors rather binding to Androgen Receptors in the cytosol of papilla cells , outer root sheath cell and sebaceous gland cells and enter into the nucleus and bind to the DNA leads to production of cell specific mRNA and synthesis of specific proteins that lead to progressive miniaturization of hair and hair loss. As these alternate pathways does not involve 5 alpha reductase, finesteride is not effective.

  2. #2
    Senior Member
    Join Date
    Jan 2015
    Posts
    217

    Default

    How r u doing on dutasteride. Has it improved?

Similar Threads

  1. Finasteride isn't working.
    By Borealis in forum Hair Loss Treatments
    Replies: 3
    Last Post: 08-25-2014, 03:30 PM
  2. HT's & working out!
    By Clark Kent in forum Hair Transplant: Start Your Own Topic
    Replies: 3
    Last Post: 11-26-2013, 09:48 PM
  3. This is not working
    By Cage in forum Hair Loss Treatments
    Replies: 4
    Last Post: 10-03-2013, 03:24 AM
  4. Finasteride working?
    By Tomb10 in forum Hair Loss Treatments
    Replies: 8
    Last Post: 08-12-2013, 07:54 AM
  5. Working out
    By Crisp in forum Hair Transplant: Start Your Own Topic
    Replies: 2
    Last Post: 04-05-2012, 01:20 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts

» IAHRS

hair transplant surgeons

» The Bald Truth

» Recent Threads

Benefits of Resveratrol for hair and health
05-05-2022 01:46 AM
Last Post By felixten
Yesterday 11:59 PM
1800 graft repair case results by Dr. Lindsey
03-27-2024 08:38 AM
Last Post By Dr. Lindsey
03-27-2024 08:38 AM
Navigating the German Job Market as a Kenyan Citizen
11-04-2023 06:31 AM
Last Post By Keegan212
03-27-2024 03:51 AM