This maybe why fin is not working for you?

[BaldingHelpMe]

Found this article:

http://www.ilht.com/mechanism-of-mal...-hair-loss.php

It says there are two pathways, one requires 5AR enzymes, and alternate pathway that does not involved 5AR enzymes, that explains why fin/dut may not be effective on some people.

This is worrying! Does this alternate pathway happen to everyone? Or just some people? I don't understand, how does testosterone get converted to DHT with just blood circulation?


From the article:

Alternate pathways

Testosterone can get converted into DHT in the blood circulation. The circulating DHT in the blood enter in the tissues including scalp tissue. In the scalp tissue DHT enter into hair follicle cells, mainly the papilla cells, outer root sheath cells and sebaceous gland cells. DHT might bind to different receptors rather binding to Androgen Receptors in the cytosol of papilla cells , outer root sheath cell and sebaceous gland cells and enter into the nucleus and bind to the DNA leads to production of cell specific mRNA and synthesis of specific proteins that lead to progressive miniaturization of hair and hair loss. As these alternate pathways does not involve 5 alpha reductase, finesteride is not effective.

[robincurtz]

How r u doing on dutasteride. Has it improved?