Anyone planning on taking the *new* Hasson and Wong liposomal topical fin?

[nobs]

Fin can't work without going systematic.

https://en.wikipedia.org/wiki/Antiandrogen

you can alter the pathway by (1) stopping production of androgens or (2) blocking the receptors that receive androgens

aka

you can either (1) tackle the quarterback, or (2) you can try to intercept the ball from a wide receiver.

fin is for tackling the quarterback....it's for stopping the ball before it's been thrown (aka stopping the production of DHT before it goes into the blood stream). Which means intercepting the ball after it's been thrown is blocking the receptor from receiving androgens (or stopping the circulating DHT from acting on the receptors in your scalp).

You can't tackle the quarterback after he's thrown the ball. In other words, fin doesn't really do anything after the ball has been thrown (or the DHT has been produced and let into the bloodstream). Thus applying it locally is like thinking you can sack the QB after he threw the ball.

The only topicals that will work are ones that shut down the AR receptor. This is ideal because you can sill have high DHT (and not be a womanly man tit boy) and still stop the baldness.

if this topical fin is working (aka lowering circulating DHT), it's because it's gone systemic.

I'll try to be less harsh than stratowich. The argument you made would mean that topical minoxidil works by entering the bloodstream, which is not the case and why topical minoxidil can be found pretty much anywhere. To add to that, all the study participants on topical minoxidil had almost undetectable levels of the drug in their bloodstream. Finasteride is a very different drug than minoxidil from a chemical standpoint(lipophilic) and is easily absorbed through the bloodstream when applied with an ethanol carrier. I for one would be more than happy to do a before and after blood test while on Hasson and Wong's product. I live in the U.S. so I have to play the waiting game like the others unless a Canadian on here is willing to do it.

[PatientlyWaiting]

Will this be readily available in the US or reliable online pharmacies or it something I have to join some secret forum for and take chemistry 101 and buy a triple beam balance to make it myself? Is it a full finished product you just buy and use?

[nobs]

Will this be readily available in the US or reliable online pharmacies or it something I have to join some secret forum for and take chemistry 101 and buy a triple beam balance to make it myself? Is it a full finished product you just buy and use?

Finished product, already available in Canada but soon to be in United States within the next month or so. https://hassonandwong.com/topical-fi...-prescription/

[mowingdown]

It’s exactly these kinds of comments from uneducated morons like you who really make me don’t want to come back to these forums anymore. You are a disgrace to society man!

Just copy-pasting a wikipedia link without even then taking the time to further elucidate the point you are trying to make.

As you are obviously so educated on all of this, please explain to us the whole metabolic pathway of finasteride… The way liposomes pass the stratum corneum and locally release finasteride in the endoplasmic reticulum…

There is a very big chance this stuff Hasson & Wong is offering is not working, but there is all a decent chance this thing is a game changer for people who are prone or are afraid of systemic side-effects.

Using some fuc**** football analogy to prove your point - what a disgrace!!! Go read these papers and all references and all publications citing these and then come back and talk to all of us again:

Love the background you provided and sources Strat. You've really brought a lot of knowledge on this specific topic and it's helped me a great deal in understanding it.

I know it's a really frustrating topic and it's hard to constantly see misinformed people (even misinformed people who may possibly be correct), but try your best not to get too heated! We are all on the boards for the same reason and thus, in this together

[mowingdown]

I'm already on topical fin from murray avenue apothecary. frankly i think they are all bullshit

Is this the liposomal mixture? or just fin in topical form?

[nobs]

Is this the liposomal mixture? or just fin in topical form?

liposome.

[BaldingEagle]

Here's the thing. Fin doesn't block DHT. It blocks 5ar2.

Fin is trapped in the scalp it's the lipo formula right? So let's say it blocks 5ar2 locally in the scalp, okay good, but... What's going to stop all 5ar2 in your prostate from making DHT and the actual DHT which fin does nothing against circulates up to your follicles?

I want to believe it works but I can't get passed my point above.

[NeedHairASAP]

Here's the thing. Fin doesn't block DHT. It blocks 5ar2.

Fin is trapped in the scalp it's the lipo formula right? So let's say it blocks 5ar2 locally in the scalp, okay good, but... What's going to stop all 5ar2 in your prostate from making DHT and the actual DHT which fin does nothing against circulates up to your follicles?

I want to believe it works but I can't get passed my point above.

this.

I'm not sure why everyone is calling me an idiot while they are the ones comparing fin to minox like it's apples to apples

[nobs]

Here's the thing. Fin doesn't block DHT. It blocks 5ar2.

Fin is trapped in the scalp it's the lipo formula right? So let's say it blocks 5ar2 locally in the scalp, okay good, but... What's going to stop all 5ar2 in your prostate from making DHT and the actual DHT which fin does nothing against circulates up to your follicles?

I want to believe it works but I can't get passed my point above.

Valid point, I was a little stumped by this at first since I forgot finasteride was an AR type 2 inhibitor and not a dht inhibitor. However, balding scalps have higher expression of 5 alpha reductase type II and when people take oral finasteride, their scalp dht levels only go down by roughly 40-50% from one of the studies I have seen on propecia, meaning their isn't a complete equilibrium between the scalp and blood levels of dht. Maybe dht produced in the prostate doesn't have the same deleterious effects on the hair follicle idk.

[burtandernie]

Yeah but merck originally formulated propecia as a topical, but went with oral from surveys from men saying oral was more convenient so it must work that way as well. It is a bit odd though inhibiting the enzyme topically would work like doing it orally