After 1 year on RU (45 mg night) my body has crashed (very serious)

[diffuseloser]

Worrying stuff. Just about to start up on it again myself. I honestly think you will be fine in a couple of weeks. Like Swoop said, try not to think about it and just look after your body with good diet and exercise. This will definitely improve things mentally and physically. Neogenic supposed to be a great vehicle for RU but I can't justify using it myself as it's too expensive. Hope you start to feel better soon please keep us posted and Happy Christmas to all.

[Swooping]

Swooping,

Goid points about RU. I'm curious to know your thougts on CB-03-01. We still don't know if it will come to the market, but would you say that it's "safer" than RU considering the infos we have right now? Would you use it without fear of cancer?

Also, could you please share your thoughts about the post finasteride syndrome? Is it really possible that finasterida destroys enzymes making sexual and mental sides permanent and irrevirsible?

I'd appreciate your feedback. Thanks!

I don't have a scientific answer to this obviously but I can tell you my opinion. I don't think at this point CB-03-01 is safer than RU58841. RU58841 has been tried obviously by way more people even at very high dosages while CB-03-01 has not, that should tell you something perhaps. My primary concern with CB-03-01 would be potential cardio(vascular) toxic effects because it's a steroidal anti-androgen, but I don't know if this applies on CB-03-01 to be honest. I think we should get the results of the 2nd clinical trial of CB-03-01 soon? Perhaps that will tell us more, also in terms pharmacokinetics (to what extent it goes systemic etc.)

Cancer risk is something I wouldn't fear at all using any anti-androgen to be honest. That being said both of these compounds are not approved so use at your own risk.

About PFS, I think upon discontinuation the side effects should be reversible, although it might take a while. So "permanent" is in my opinion a big word to use. I do certainly believe that some people get sides on finasteride and some very unlucky people can have lingering side effects upon discontinuation. But permanent?

[Paul73]

Thanks for the analysis, Swooping.

I didn't know about the cardio toxic effects, that's a red flag for sure.

I am trying to elaborate a regimen without finasteride. I use it for almost two decades and need to stop it.

I was considering RU, but have seen many threads (like this one) reporting really bad reactions. Then CB called my attention, there are more and mode people experimenting with it.

But again comes the fear of a non approved substance.

I guess i will listen to your advice and wait the results of the second clinical trials. I hope we can see relevant information about safety there.

Thanks again for your reply. Btw, if you don't mind to share,
what are you using to combat MPB?

[mrkite]

How are you doing, OP?

I don't have a scientific answer to this obviously but I can tell you my opinion. I don't think at this point CB-03-01 is safer than RU58841. RU58841 has been tried obviously by way more people even at very high dosages while CB-03-01 has not, that should tell you something perhaps.

You should know the reason for this. CB is much harder to obtain, not to mention very expensive.

My primary concern with CB-03-01 would be potential cardio(vascular) toxic effects because it's a steroidal anti-androgen, but I don't know if this applies on CB-03-01 to be honest. I think we should get the results of the 2nd clinical trial of CB-03-01 soon? Perhaps that will tell us more, also in terms pharmacokinetics (to what extent it goes systemic etc.)

What are you basing these cardiovascular health concerns on exactly?

[dutchguyhanging]

How are you doing, OP?

You should know the reason for this. CB is much harder to obtain, not to mention very expensive.


What are you basing these cardiovascular health concerns on exactly?

guys guys, we are talking about cardiovascular health issues here... drop the pill asap and go to a doctor... these type of issue can be vital at young age... i repeat do not use RU... thnks

[Swooping]

@Paul73

I have had a hair transplant so my only concern is maintenance now really. I don't need regrowth that much anymore. I'm using RU currently but going to trial finasteride next month again. I'm thinking of actually cycling these two on and off with breaks in between. So something like 6 months RU / 6 months off/ 6 months finasteride. Nothing too fancy though as you can see, my goal is to work with a minimum maintenance treatment at the moment until better options come along.

[paleocapa89]

hey melanopsin! How are you doing now? Hope you are better.

[Trouse5858]

@Paul73

I have had a hair transplant so my only concern is maintenance now really. I don't need regrowth that much anymore. I'm using RU currently but going to trial finasteride next month again. I'm thinking of actually cycling these two on and off with breaks in between. So something like 6 months RU / 6 months off/ 6 months finasteride. Nothing too fancy though as you can see, my goal is to work with a minimum maintenance treatment at the moment until better options come along.

Wow you sprung for the hair transplant without being compatible with fin? I'm really screwed since I have diffuse loss, got gyno from RU and ED from fin so don't think a HT is realistic for me right now. How many nor woods did the HT give you back??

[Swooping]

Wow you sprung for the hair transplant without being compatible with fin? I'm really screwed since I have diffuse loss, got gyno from RU and ED from fin so don't think a HT is realistic for me right now. How many nor woods did the HT give you back??

Well, I am somewhat compatible with finasteride. I just get minor side effects. I'll trial it soon at a lower dosage though. I'm making sure I'll stay above baseline as best as I can.

Yeah it s*cks dude when you get side effects on current treatments. Maybe try something like alfatradiol? Weak but perhaps it will slow it down for you somewhat...

I think I reversed 3 norwood with the HT;

http://s8.postimg.org/c225yffhx/7halfmonth.jpg

http://s8.postimg.org/usywuex6b/journeyht.jpg (sorry the scabs look a bit nasty i guess)

[Dimoxynil]

Well, I am somewhat compatible with finasteride. I just get minor side effects. I'll trial it soon at a lower dosage though. I'm making sure I'll stay above baseline as best as I can.

Yeah it s*cks dude when you get side effects on current treatments. Maybe try something like alfatradiol? Weak but perhaps it will slow it down for you somewhat...

I think I reversed 3 norwood;

http://s8.postimg.org/c225yffhx/7halfmonth.jpg

http://s8.postimg.org/usywuex6b/journeyht.jpg (sorry the scabs look a bit nasty i guess)

You've had a HT though yea ? Surely you didn't achieve this just using treatments ?

[Swooping]

You've had a HT though yea ? Surely you didn't achieve this just using treatments ?

Yeah, that's a HT, look at the scabbing, redness and stuff, almost 3000 grafts by FUE.

[Dimoxynil]

Yeah, that's a HT, look at the scabbing, redness and stuff, almost 3000 grafts by FUE.

How is the scarring ? Congratulations mate you must feel great when you look in the mirror ? Can I also ask where you got it done and how much it cost ?

[Trouse5858]

Those results are awesome. I don't know what the back looks like but you've got a full head of hair even to a grandmaster at spotting MPB lol, congrats.

[diffuseloser]

Wow those are amazing results. I'd love to get a HT but is shock loss as big a problem as they say it is? I'm diffuse obviously and have been advised against it by the surgeons I had consultation with. However, I have seen a lot of promising results with diffuse loss online. I wouldn't be too bothered if I lost some hair providing it eventually grew back. Just at a loss as to what way to tackle the problem. I want my mojo back. RU will have to do for now.

[Swooping]

How is the scarring ? Congratulations mate you must feel great when you look in the mirror ? Can I also ask where you got it done and how much it cost ?

My donor was handled with a 0.7mm punch. The scarring is almost not visible from what I can see. I'll shave my head in the future so I can look at how the scarring is. My donor area looks good though. Jup it's great obviously mate . Don't need regrowth anymore. Would love better preventative options.

Sure, I have done the procedure in Turkey with Doganay. Costed me almost 5500 euro. If you consider a hair transplant please do good research. I'ts VERY important. Don't ever pick a surgeon because you see one success example.

Those results are awesome. I don't know what the back looks like but you've got a full head of hair even to a grandmaster at spotting MPB lol, congrats.

Thanks mate . My donor looks good. I never shaved it though to the bone.

Wow those are amazing results. I'd love to get a HT but is shock loss as big a problem as they say it is? I'm diffuse obviously and have been advised against it by the surgeons I had consultation with. However, I have seen a lot of promising results with diffuse loss online. I wouldn't be too bothered if I lost some hair providing it eventually grew back. Just at a loss as to what way to tackle the problem. I want my mojo back. RU will have to do for now.

Thanks mate. Shock loss? Not if you with a good surgeon in my opinion who is great at grafting in between native hair. It can become a problem however if you current native density is too high. In that case even the most skilled hands can't place the grafts in between the native hair follicles without causing transection. A good surgeon will know his limits and capabilities. I did have shock loss in my donor area btw but it grew back.

Have a look here for instance in this video gallery diffuseloser; https://www.youtube.com/user/shubbapahte/videos. You'll see some people who are losing hair in a diffuse manner too and got (major) cosmetic difference! Take enough time for research if you are willing to go with a HT eventually. I can't stress how important that is. Good luck man .