– These fascinating JAK inhibitor drugs have a multi-faceted effect on hair follicles. Here are some descriptions of their method of action from the published study:
JAK inhibitors stimulate hair follicles out of the resting phase into the growing phase. They also show the ability to elongate the growing phase.
JAK inhibitors activate the Wnt and Shh signaling pathway.
JAK inhibitors cause the activation of hair follicle progentior (stem) cells.
Tofacitinib (a JAK inhibitor) promotes inductivity of dermal papillae cells.
Tofacitinib promotes hair growth by positively affecting genes within pathways that are crucial to hair growth. For example: TGFB pathway genes, BMP pathway genes, LEF1, and NOTCH pathway genes.
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