Most giant discoveries in science aren't just made over night by one person... they are from an accumulation of knowledge contributed to by many scientists and even just smart individuals. I am happy we have people of all capacities and resources exploring this, it needs to happen more. Proof or no proof, this makes me happy.
I think I've hacked it
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Most giant discoveries in science aren't just made over night by one person... they are from an accumulation of knowledge contributed to by many scientists and even just smart individuals. I am happy we have people of all capacities and resources exploring this, it needs to happen more. Proof or no proof, this makes me happy.Comment
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Most giant discoveries in science aren't just made over night by one person... they are from an accumulation of knowledge contributed to by many scientists and even just smart individuals. I am happy we have people of all capacities and resources exploring this, it needs to happen more. Proof or no proof, this makes me happy.
It was kind of off topic, but it shows what you said that something can't be done over night by one person is very true and it applies to all science fields, even one of the most intelligent beings in History. It had to be done by many many scientists over the course of multiple decades. Now don't get me wrong I don't want it to take 100 more years, hopefully it doesn't take until the year 2116 to get a hair loss cure lol. But I agree with your post.Comment
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I don´t know if the thread starter is still following this thread. But lets try.
According to your theory, it is important to not only prevent the androgen-AR-interaction but also androgen independent AR activation (translocation into the nucleus). Therefore one has to either make the AR disappear altogether (like you tried to) or induce a permanent loss of intranuclear function of the androgen receptor. There are hundreds of known mutations that cause androgen insensitivity. A few of them will not only affect the androgen-AR-interaction but also to intranuclear affinity of the AR to its target.
What do you think of inducing such a point mutation via chimeric DNA/RNA oligonucleotids? The site directed mutations could be induced ex situ by extracting the hair follicles in order to prevent systemic side effects.Comment
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I don´t know if the thread starter is still following this thread. But lets try.
According to your theory, it is important to not only prevent the androgen-AR-interaction but also androgen independent AR activation (translocation into the nucleus). Therefore one has to either make the AR disappear altogether (like you tried to) or induce a permanent loss of intranuclear function of the androgen receptor. There are hundreds of known mutations that cause androgen insensitivity. A few of them will not only affect the androgen-AR-interaction but also to intranuclear affinity of the AR to its target.
What do you think of inducing such a point mutation via chimeric DNA/RNA oligonucleotids? The site directed mutations could be induced ex situ by extracting the hair follicles in order to prevent systemic side effects.Comment
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Forgot to say: the idea of fgf11 is not far fetched at all and far from being a scam. If you believe that finasteride works, then you have to believe that his idea works. He just takes it a step further. His approach is not some magical snake oil but an approach that researches use daily to investigate the role of all kinds of proteins in in vitro experiments.
This forum is a mixture of all kinds of people from different backgrounds. His motivation most propably was: I have a good idea but not the time or resources to develop it on a bigger scale so I at least want it to be a stepping stone for someone who really works in this field.Comment
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