hair-GEL (gene expression library)

[joachim]

interesting:

http://www.sciencedaily.com/releases/2015/10/151029185557.htm

[baldybald]

Really interesting, but not for us it is for the next generation

[lacazette]

Wow huge Joachim, it will be EXTREMELY useful !( and not for the next gen, for us Baldybald

it will elucidate at the molecular level what it is exactly needed to grow functionnal hair on skingraft (like US army researchers) or after wounding! ( thanks to michael Rendl's lab, they are top for us as they exclusively work on understanding the hair follicle world)



"The work is central to understanding the interactions between stem cells and their environment -- or "niche cells" -- during fetal development, and will specifically facilitate future attempts to make skin grafts with functional hair follicles or to regenerate lost hair in patients."

"The new tool and our initial analyses take a molecular snapshot of stem cells and niche cells as they interact to form hair follicles,"

"We know these cells are important for coordinating hair growth, but we don't know how they communicate on a molecular level to achieve such a complex process.
Our goal in publishing this database is to construct a launching pad for future studies that will clarify the role of all signals driving this developmental program -- with the ultimate goal of transitioning this knowledge to the clinical setting."

"Using next-generation RNA-sequencing, the research team compared transcriptomes in embryonic skin cells to uncover hundreds of genes that are active as skin develops, including those that guide the formation of hair follicles."


"While this work provides the first high-resolution molecular study of hair follicle precursor cells, its true power comes from analyzing these cells in the context of the entire developing skin,"


"As hair follicles form, many other cells in the local environment simultaneously coordinate epidermal and dermal maturation, pigment cell migration, nerve cell distribution, and more. By comparing the genome-wide RNA-sequencing analysis of distinct cell types isolated from embryonic skin, the research team uncovered unique genes associated with each one.
These aptly named "gene signatures" in turn reveal the messages specific cell types send and receive as they communicate and cooperate to form skin and all of its complex compartments


"Such genes could represent core factors that establish stem or niche cell identity and activity, and could be useful to promote hair growth in a clinical setting.
The authors additionally confirm the activity of defined signaling pathways, known to be important in diverse developmental programs, but for the first time pinpoint cells throughout the skin that take part in these molecular conversations.
"Finally, they highlight the widespread activation of signals previously defined by their role in axon guidance signaling, which could have a heretofore unrecognized role in directing the large scale cellular rearrangements important for functional skin development"


"The team is sharing all data in an interactive, searchable Hair Gene Expression Library website (Hair-GEL.net) that offers sequencing information on the stem cells and niche cells that interact to build hair follicles. Researchers can query any gene of interest to see if it is present and/or specifically expressed in any one of the distinct cell types that compose embryonic skin.



It will give a big help to any researchers currently working on a cure and so shorten the timeline

[WHTC Clinic]

Very interesting possibility of improving cell proliferation, but it's no exact science. Genetic or androgenic alopecia isn't going away anytime soon.

[baldybald]

Very interesting possibility of improving cell proliferation, but it's no exact science. Genetic or androgenic alopecia isn't going away anytime soon.

That is what am saying, things are improving well but very slowly. Not for us but next generation

[ShookOnes]

That is what am saying, things are improving well but very slowly. Not for us but next generation

how long would you place a timeline for the next generation and not us? I highly expect a cure to be discovered in 15-20 years, 25 for commercialization... wbu? just wondering.

[jpar]

give up on it, go get a transplant or finesteride at WHTC clinic. its for the next generation. theres no use even being on these forums if not shti is going on