Increasing the hair inductive potential of DP cells

[lacazette]

SARI, AGNES ROSARINA PRITA is a researcher from melbourne, and here it's her master research thesis:


Increasing the hair inductive potential of human dermal papilla cells: stimulating and characterising cell aggregation

https://minerva-access.unimelb.edu.a...le/11343/55427

Dermal papilla cells (DPCs) are able to induce hair follicles. DPC tend to aggregate both in vitro and in vivo. This tendency is associated with their ability to induce hair growth. The use of DPCs to treat alopecia is limited because human DPCs lose their hair-inducing activity in culture, whereas ovine DPC do not.

The aims of this study were to characterise the molecular phenotype of ovine DPC aggregates, and to determine whether aggregating ovine DPCs secrete factors affecting the aggregative behaviour or inductive potential of human DPCs.

Expression of papilla markers in cultured ovine DPCs was characterised. The effects of ovine factors, different culture substrates and medium compositions on aggregative behaviour of human DPCs were determined. Co-cultures of ovine and human papilla cells, separated by a permeable membrane were observed to determine whether the ovine cells secrete soluble factors that affect human cell aggregation.

Ovine DPC aggregates expressed 16 papilla markers, showing they have a similar phenotype to papillae in vivo. In co-culture experiments, well-formed aggregates were produced in humanvine DPC mixtures. In contrast, unmixed human DPCs remained in a monolayer state, indicating that ovine cells are required to initiate aggregation but the human cells are then able to incorporate into aggregates. Both human and ovine DPCs had a higher tendency to aggregate in medium containing 20% (v/v) lamb serum compared to 10% (v/v) foetal calf serum. The effect of co-culturing human with ovine DPCs separated by a permeable membrane gave positive additional effects to human aggregation.

In summary, ovine biomolecules show potential for increasing the aggregative behaviour of human DPCs in culture. These biomolecules might eventually be used to treat androgenetic alopecia.
"


So apparently her biovine molecules could help to culture inductive DP cells for a cellular therapy, but could also eventually be used directly as a medication for existing hair

I saw also that she was one of the travel grant recipients from the 2014 World Congress Hair Research
http://www.hair2014.org/Contents.asp...14&openpage=14

Her work seems quite interesting but I don't find her contact info, would like to ask what she is doin now, if she had link with a company or what,etc.. so if someone find it

[nameless]

This is interesting but they can't inject ovine cells into humans because doing so would trigger an immune response.

[noisette]

Hi bro,
I found her facebook lol : https://www.facebook.com/agnes.pritasari

[JayM]

Get in her DM's son.

[JayM]

She is the media and communications officer on whatever she does anyway. So could be a good shout getting a reply

[baldybald]

Now, do we need to understand the hair loss mechanism to find the cure ?

[Vic]

Now, do we need to understand the hair loss mechanism to find the cure ?

Can't solve the problem without knowing what the problem is