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hey guys, not hair related but infact it could be
"Mesoblast and Japanese company JCR Pharmaceuticals announced approval of Temcell (allogeneic mesenchymal stromal cell-based product) in pediatric acute GVHD in Japan. This is the first product to be approved under the Japanese “regenerative medicine law” that allows cell therapy treatment to go from a phase 1 directly to commercialization.
TEMCELLŽ HS Inj., the first allogeneic regenerative medicine product in Japan for intravenous infusion, is isolated and expanded mesenchymal stem cells (MSCs) derived from bone marrow aspirate of healthy adult donors. It is an innovative therapy in view
of utilizing the MSCs’ properties to treat the disease."
First I like the fact that it is confirming that the temp approval occured at the end of phase1 /beginning of phase 2.
Second the allogeneic MSCs derived from bone marrow they are using in this approved treatment, could maybe also lead to a hair therapy :
Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth
Our study reveals that BM-MSC-generated Wnt1a promotes the DP's ability to induce hair cycling and regeneration.
29 jun 2015
Wnt-CM was prepared from the supernatant of Wnt1a-expressing bone marrow mesenchymal stem cells (BM-MSCs) that maintain the hair-inducing gene expression of DP cells.
The results demonstrate that Wnt-CM can maintain the hair induction ability of DP cells in expansion cultures, and this approach can be used for large-scale preparation of CCS cells in vitro to treat hair loss
So the problem with aderans kind of treatment, is that during cultivation and expansion of DP cells, they lose their hair induction capacity
Here above they show that this can be solved when cultivated with bone marrow derived MSCs
But I read in another study that the amount of MSCs-BM they can take from one individual is not sufficient to make a therapy. That's why that first treatment that has been approved under temp app is interesting, cause they use allogeneic MSCs. So this mean no more amount of MSCs problem
DP induction is solved, if 'Allogeneic MSCs' is solving the MSCs amount problem, then a therapy like they suggest in the 2 studies could come out of that
a treatment that would consist of cultivation of DP cells with allogeneic MSCs-BM is an aderans 2.0 kind of treatment, that don't have the iPSCs current issues
let's see how the TEMCELL product goes in japan, and maybe i'll try also to contact those chinese researchers or their institute in those 2 studies, cause maybe they are already testing their method in human or planning trials
"Mesoblast and Japanese company JCR Pharmaceuticals announced approval of Temcell (allogeneic mesenchymal stromal cell-based product) in pediatric acute GVHD in Japan. This is the first product to be approved under the Japanese “regenerative medicine law” that allows cell therapy treatment to go from a phase 1 directly to commercialization.
TEMCELLŽ HS Inj., the first allogeneic regenerative medicine product in Japan for intravenous infusion, is isolated and expanded mesenchymal stem cells (MSCs) derived from bone marrow aspirate of healthy adult donors. It is an innovative therapy in view
of utilizing the MSCs’ properties to treat the disease."
First I like the fact that it is confirming that the temp approval occured at the end of phase1 /beginning of phase 2.
Second the allogeneic MSCs derived from bone marrow they are using in this approved treatment, could maybe also lead to a hair therapy :
Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth
Our study reveals that BM-MSC-generated Wnt1a promotes the DP's ability to induce hair cycling and regeneration.
29 jun 2015
Wnt-CM was prepared from the supernatant of Wnt1a-expressing bone marrow mesenchymal stem cells (BM-MSCs) that maintain the hair-inducing gene expression of DP cells.
The results demonstrate that Wnt-CM can maintain the hair induction ability of DP cells in expansion cultures, and this approach can be used for large-scale preparation of CCS cells in vitro to treat hair loss
So the problem with aderans kind of treatment, is that during cultivation and expansion of DP cells, they lose their hair induction capacity
Here above they show that this can be solved when cultivated with bone marrow derived MSCs
But I read in another study that the amount of MSCs-BM they can take from one individual is not sufficient to make a therapy. That's why that first treatment that has been approved under temp app is interesting, cause they use allogeneic MSCs. So this mean no more amount of MSCs problem
DP induction is solved, if 'Allogeneic MSCs' is solving the MSCs amount problem, then a therapy like they suggest in the 2 studies could come out of that
a treatment that would consist of cultivation of DP cells with allogeneic MSCs-BM is an aderans 2.0 kind of treatment, that don't have the iPSCs current issues
let's see how the TEMCELL product goes in japan, and maybe i'll try also to contact those chinese researchers or their institute in those 2 studies, cause maybe they are already testing their method in human or planning trials
I was quite busy and made a little break about all hairloss related things, I'll post again now what i see 
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