I think it can be obvious that it is linked with TLR3 discovery in august by Dr Luis GARZA's team ( GARZA and Cotsarelis used to work together on many studies) :
"Researchers Identify Drug Candidate for Skin, Hair Regeneration Among Scarred Victims of Burns and Trauma"
Johns Hopkins researchers have identified a novel cell signaling pathway in mice through which mammals — presumably including people — can regenerate hair follicles and skin while healing from wounds.
The discovery, summarized in an article published Aug. 6 in the journal Cell Stem Cell, could, they say, eventually help spur the growth of new hair, skin or other organ tissue in scarred victims of burns and other injuries.
Our study “uncovers a novel role for a protein that works as a master regulator of regeneration in the skin,” says senior study author Luis A. Garza, M.D., Ph.D., associate professor of dermatology at the Johns Hopkins University School of Medicine. “Medications that turn on this protein have the powerful potential to decrease scarring as healing of wounds takes place, thereby promoting skin and hair follicle regeneration.”
During wounding TLR3 activates the genes IL6 and STAT3 to promote hair follicle regeneration.
TLR3 also activates other molecules involved in hair development, including the Wnt and Shh signaling pathways and a gene called EDAR, which makes the protein ectodysplasin and plays an important role in skin development.
could be directly used to stimulate rejuvenation in aging or hair follicle growth in burn patients to regain structures that have been lost
The clinical translation of this work is promising because work has already started, says Garza. Drug companies
are already developing products to activate TLR3 to trigger the immune system, and these same products could be tested to promote regeneration. "
It's exactly what follica needed.
Wounding the scalp, then TLR3 activation to regain the hair follicles structures, and then daily Wnt activation to promote the growth of these new hair follicles. Sounds good
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