Pax1/Foxa2- 1 of the primary genetic reasons why we balding men- are balding

[eldarlmario]

PAX1 gene: http://www.genecards.org/cgi-bin/carddisp.pl?gene=PAX1

FOXA2 gene: http://www.genecards.org/cgi-b...=FOXA2&keywords=foxa2

So to summarise my opinion on the all literature sources i have read in relation to the pathology of AGA:

1)IMO, not all studies are accurate. Some older studies were even refuted by later studies.
2)Not all proposed/suggested pharmalogical solutions in those studies were effective. Some were even refuted as being harmful to the hair follicles in later experiments.
3)The best indicative and in IMO referral source on the pathology of AGA in my course of reading countless studies on literature relevant to AGA comes from the Scoliosis study. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365504/ The fact that Idiopathic Scoliosis http://en.wikipedia.org/wiki/S...tionary_considerations , and not AGA- was the (A)original intended topic of the study, along with the fact that the gene locus indicated by the study and supported by (B)others as being a genetic susceptibility locus in multiple ethnic groups for AGA further lends its findings enhanced credibilit(on AGA):

(A)"Unexpectedly, the 20p11.22 IS risk alleles were previously associated with protection from early-onset alopecia, another sexually dimorphic condition."*

(B) Abstract

Background

Androgenetic alopecia (AGA) is a well-characterized type of progressive hair loss commonly seen in men, with different prevalences in different ethnic populations. It is generally considered to be a polygenic heritable trait. Several susceptibility genes/loci, such as AR/EDA2R, HDAC9 and 20p11, have been identified as being involved in its development in European populations. In this study, we aim to validate whether these loci are also associated with AGA in the Chinese Han population.

Methods

We genotyped 16 previously reported single nucleotide polymorphisms (SNPs) with 445 AGA cases and 546 healthy controls using the Sequenom iPlex platform. The trend test was used to evaluate the association between these loci and AGA in the Chinese Han population. Conservatively accounting for multiple testing by the Bonferroni correction, the threshold for statistical significance was P ?3.13×10?3.

Results

We identified that 5 SNPs at 20p11 were significantly associated with AGA in the Chinese Han population (1.84×10?11?P?2.10×10?6).

Conclusions

This study validated, for the first time, that 20p11 also confers risk for AGA in the Chinese Han population and implicated the potential common genetic factors for AGA shared by both Chinese and European populations.

http://journals.plos.org/ploso.../journal.pone.0071771

We carried out a genome-wide association study in 296
individuals with male-pattern baldness (androgenetic alopecia)
and 347 controls. We then investigated the 30 best SNPs in an
independent replication sample and found highly significant
association for five SNPs on chromosome 20p11 (rs2180439
combined P ¼ 2.7
1015). No interaction was detected
with the X-chromosomal androgen receptor locus, suggesting
that the 20p11 locus has a role in a yet-to-be-identified
androgen-independent pathway.(possibly why castrates dont regrow hair)

http://neurogenetics.qimrbergh...llmer2008NatGenet.pdf

Male-pattern baldness susceptibility locus at 20p11

J Brent Richards,1,2 Xin Yuan,3 Frank Geller,4 Dawn Waterworth,3 Veronique Bataille,1 Daniel Glass,1 Kijoung Song,3 Gerard Waeber,5 Peter Vollenweider,5 Katja K H Aben,6,7 Lambertus A Kiemeney,8,9 Bragi Walters,4 Nicole Soranzo,1,10 Unnur Thorsteinsdottir,4 Augustine Kong,4 Thorunn Rafnar,4 Panos Deloukas,10 Patrick Sulem,4 Hreinn Stefansson,4 Kari Stefansson,4 Tim D Spector,1,11 and Vincent Mooser3,11
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Abstract
We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 × 10?14 for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 × 10?15).

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672151/