Hair follicle neogenesis induced by cultured human scalp dermal papilla cells

[Renee]

Looks like this is a new study because it sites christiano's/ jahoda's work from 2013.


Research Article
Hair follicle neogenesis induced by cultured human scalp dermal papilla cells

Jizeng Qiao1, Agatha Zawadzka1, Erica Philips1, Anya Turetsky1, Susan Batchelor2, Jillian Pea****2, Steven Durrant2, Darren Garlick2, Paul Kemp2 & Jeff Teumer1†
† Author for correspondence

Aim: To develop a method by which human hair follicle dermal papilla (DP) cells can be expanded in vitro while preserving their hair-inductive potential for use in follicular cell implantation, a cellular therapy for the treatment of hair loss. Materials & methods: DP cells were isolated from scalp hair follicles in biopsies from human donors. DP cell cultures were established under conditions that preserved their hair-inductive potential and allowed for significant expansion. The hair-inductive potential of cells cultured for approximately 36 doublings was tested in an in vivo flap-graft model. In some experiments, DiI was used to label cells prior to grafting. Results: Under the culture conditions developed, cultures established from numerous donors reproducibly resulted in an expansion that averaged approximately five population doublings per passage. Furthermore, the cells consistently induced hair formation in an in vivo graft assay. Grafted DP cells appeared in DP structures of newly formed hairs, as well as in the dermal sheath and in the dermis surrounding follicles. Induced hair follicles persisted and regrew after being plucked 11 months after grafting. Conclusion: A process for the propagation of human DP cells has been developed that provides significant expansion of cells and maintenance of their hair-inductive capability, overcoming a major technical obstacle in the development of follicular cell implantation as a treatment for hair loss.


http://www.futuremedicine.com/doi/abs/10.2217/rme.09.50

[Renee]

Looks like these researchers solved the main issue.

[Renee]

Looks like this is old from 2009 intercytex.

[nameless]

Looks like this is old from 2009 intercytex.

Can you please clarify things. First you said that the study cites work done by Christiano and Jahoda in 2013 but then you say this study is actually from 2009. How can a 2009 study cite work done by Jahoda and Christiano in 2013. Please clarify.

[BDDFreak]

yeah this study also sites another study from january 2015. I think this is new.

[allTheGoodNamesAreTaken]

Can you please clarify things. First you said that the study cites work done by Christiano and Jahoda in 2013 but then you say this study is actually from 2009. How can a 2009 study cite work done by Jahoda and Christiano in 2013. Please clarify.

"Cited by:

...


Chris Mason, Elisa Manzotti. (2009) Bioaesthetics and regenerative medicine. Regenerative Medicine 4:5, 635-637.
Online publication date: 1-Sep-200917-Sep-2009."

[BDDFreak]

"Cited by:

...


Chris Mason, Elisa Manzotti. (2009) Bioaesthetics and regenerative medicine. Regenerative Medicine 4:5, 635-637.
Online publication date: 1-Sep-200917-Sep-2009."

Thats the publication date of that study which is cited, not the study which is in question at the top. Look at all the "online publishing dates" of material under "cited by". There are various online publishing dates. For example:

Heidi Debels, Moustapha Hamdi, Keren Abberton, Wayne Morrison. (2015) Dermal Matrices and Bioengineered Skin Substitutes. Plastic and Reconstructive Surgery Global Open 3, e284.
Online publication date: 1-Jan-2015.
CrossRef

[JayM]

yeah this study also sites another study from january 2015. I think this is new.

The list is studies that have cited this study. If you look at the volume it was released in it was in 2009.

[BDDFreak]

The list is studies that have cited this study. If you look at the volume it was released in it was in 2009.

Oh my fault, that makes sense. Thanks!

[Replicel55]

So if they solved it why did intercytex shut down and why arent they running trials?