Regience

[Renee]

Anybody heard of this Japanese company called Regience?

regience.jp/english/

They are trying to develop a cell based cure for hairloss and have partnered with Riken & Tokyo university.

[Renee]

http://www.cdb.riken.jp/org/en/research/organ/hair.html

[Renee]

Regience K.K. (hereafter, Regience) and RIKEN, Institute of Physical and Chemical Research (hereafter, RIKEN) made an agreement of collaboration to study toward “derivation and cultivation of hair follicle-related stem cells maintaining high potency to reconstruct the hair follicle”. In this collaboration, the expertise of RIKEN (the profound knowledge of Extracellular Matrix; ECM, accumulated by Dr. Hironobu Fujiwara, Team Leader of Tissue Microenvironment, Center for Developmental Biology; CDB, RIKEN) and of Regience (the technology of 3D cultivation system in which a biological environment suitable for the proliferation of mammalian cells is reproduced) will be combined to create stem cell niche* in vitro.This project is expected to leads to the final goal of the successive reconstruction of hair follicle in vitro.

[nameless]

Regience K.K. (hereafter, Regience) and RIKEN, Institute of Physical and Chemical Research (hereafter, RIKEN) made an agreement of collaboration to study toward “derivation and cultivation of hair follicle-related stem cells maintaining high potency to reconstruct the hair follicle”. In this collaboration, the expertise of RIKEN (the profound knowledge of Extracellular Matrix; ECM, accumulated by Dr. Hironobu Fujiwara, Team Leader of Tissue Microenvironment, Center for Developmental Biology; CDB, RIKEN) and of Regience (the technology of 3D cultivation system in which a biological environment suitable for the proliferation of mammalian cells is reproduced) will be combined to create stem cell niche* in vitro.This project is expected to leads to the final goal of the successive reconstruction of hair follicle in vitro.

5 - 10 years away Renee.

I'm glad they're doing this research but if SM04554 is safe and effective it will be available much MUCH sooner.

[joachim]

sounds great! more and more research is done now around hair follicles.
i have no doubt. all the remaining puzzles will be solved within the next 3 years, and lab-grown follicles in vitro will be a realitiy.
unfortunately, from that day on it will still require years to get it to market.
i hope with japan's new laws they can find a way to bring a cure within 5 years. i think it's optimistic, but possible.

[Sogeking]

sounds great! more and more research is done now around hair follicles.
i have no doubt. all the remaining puzzles will be solved within the next 3 years, and lab-grown follicles in vitro will be a realitiy.
unfortunately, from that day on it will still require years to get it to market.
i hope with japan's new laws they can find a way to bring a cure within 5 years. i think it's optimistic, but possible.

Yes finally people have started working on AGA problem. But I still feel bitter about the fact that all of this activity and research should have started 5 years ago at least...

In this case they are talking about cultivating stem cells for hair follicles in vitro. Meaning they have to create them in lab in controlled environment. And afterwards they have to test it on mice and then on humans. This will take a lot of years.

[Renee]

Yes but they have partnered with Riken, which is where tsuji did his research on hair in 2012. So I'm assuming they are not starting from scratch. I emailed the company hopefully they respond.

[Renee]

Riken & tsuji lab from 2012:

The organ germ method, that we previously developed could autonomously regenerate fully functional hair follicle and tooth from the fetal germ cells.
We developed the organ germ method to apply the technology to adult cells in order to regenerate hair follicles that are normally connected to the dermal epidermal layer and other tissues.

This technology, a major breakthrough in the practical use of hair regenerative therapy, enables the reproductive hair follicle to connect adequately to the surrounding tissues and to be reproduced functionally. In the future, we will contribute to hair regenerative therapy via transplantation therapy through the reproduction of hair follicle germ with autologous stem cells.

[Renee]

There is another company based in japan called organ technologies inc.

http://www.organ-technol.co.jp/en/profile.html

Takashi tsuji is a director.

[joachim]

There is another company based in japan called organ technologies inc.

http://www.organ-technol.co.jp/en/profile.html

Takashi tsuji is a director.

you and lazacette are really bringing up lots of good info and research. seems like you're digging out some new stuff every day :-)
being proactive is key here. the answer is somewhere out there.

thanks so much for the good work! (just felt the need to say that right now)

[Renee]

Joachim, thanks for the kind words. I'm a firm believer there is research and trials currently going on that we don't know about, I try to dig and find out.

Regience has partnered with kotaro yoshimura. This guy has been researching a lot on hair loss. I have attached a study he did in 2010 using dermal papilla cells.

http://www.researchgate.net/publication/49821599_Clinically_applicable_transplantation_procedure_of_dermal_papilla_cells_for_hair_follicle_regeneration

[lacazette]

That is great!! Riken center are probably the most Advanced in the organ regeneration knowledge and Tools. This regience company also made agreements for a collaboration with some Osaka and Tokyo universties high researchers that work on hair, and also with ROHTO Pharmaceutical to develop the clinical application based on in vitro and in vivo results

This company wants to be a leading company in regenerative medecine, and regarding hair, their multiple agreements will at least help the preclinical research to find that possible clinical application. They seems to gather all the knowledge/methods needed

"In August 2014, Regience made an agreement for collaboration research with Professor, Daisuke Tsuruta and visiting Professor, Katsutoshi Yoshizato in Department of Dermatology, Osaka City University Graduate School of Medicine, to develop regenerative medicine products for the treatment of alopecia and promotion of hair growth.
Professor, Daisuke Tsuruta and Lecturer, Kouji Sugawara are leading researchers in the dermatology field of hair growth, who developed cultivated human hair follicle model and animal hair cycle model
Regience starts the collaboration research to regenerate the hair cycle, consisting of growth, destruction and resting phases as intrinsic state and for this goal, the accumulating technologies Professor Tsuruta and Lecturer Sugawara established will be employed.


"Regience made an agreement with Tokyo University and ROHTO Pharmaceutical Co., Ltd. for collaboration research to the regeneration medicine of hair. Through this collaboration, Regience aims for the clinical application of regenerative medical products, developed upon the in vitro and in vivo studies with Koutaro Yoshimura,"

[lacazette]

"Innovative technologies including iPS cells are being created in Japan. We are aiming to utilize these technologies in the field of regenerative medical products and obtain the approval in foreign countries as well to sell these products. Besides, we are also aiming to develop one and only product in the world utilizing robotics and other manufacturing technologies"

the company president :
“Our purpose is to create innovative medicine in the field of regenerative medicine utilizing technologies originated in Japan and deliver it to the patients who need it all over the world as soon as possible.”

"Regenerative Medicine Industrialization Task Force (RMIT) has been established as a task force under Forum for Innovative Regenerative Medicine (FIRM). Japan has set up the most advanced legal and regulatory environment for industrialization of regenerative medicine and cell therapy since the progressive legislations that took place in the autumn of 2014. Encouraged by that, some of the FIRM member companies have volunteered to organize RMIT and organized an industrialization support team as its initiating activity. This support team is meant to help wide spectrum of organizations such as established mega pharmas, emerging venture businesses, or thriving academia, domestic and overseas alike, resolving various bottlenecks that hinder prompt industrialization of regenerative medicine and cell therapy."

[FooFighter]

Fantastic news for my mouse!

[JayM]

Fantastic news for my mouse!

Oh no I'm really sorry to hear that your mouse has lost it's hair