+ Reply to Thread
Page 2 of 8 FirstFirst 1 2 3 4 ... LastLast
Results 11 to 20 of 73
  1. #11
    Senior Member
    Join Date
    May 2015
    Location
    france
    Posts
    395

    Default

    Ok I find the infos, on the igem exhibition website.

    Here is their team registration page for the event :
    http://igem.org/Team.cgi

    And when you click on "about our project form", you'll get that : http://2015.igem.org/Safety/About_Ou...t?team_id=1674

    "The main goal is to degrade DHT (Dihydro-testosterone), which causes male baldness. We are planing to do this by cloning the 3-alpha-HSD gene () from Rat liver origin into E.Coli and B.Subtilis. This enzyme converts the substance into it's inactive and safe form.

    We plan that the bacteria will be applied onto the scalp with a special comb.

    How would your project be used in the real world?
    In a consumer product that ordinary people buy

    Regular lab strains: E.Coli: top10, DH5alpa, BL21
    B.Subtilis: PY79


    There's also on the page the names of the 5 instructors and the 10 students

  2. #12
    Senior Member
    Join Date
    May 2014
    Posts
    561

    Default

    Quote Originally Posted by lacazette View Post
    Ok I find the infos, on the igem exhibition website.

    Here is their team registration page for the event :
    http://igem.org/Team.cgi

    And when you click on "about our project form", you'll get that : http://2015.igem.org/Safety/About_Ou...t?team_id=1674

    "The main goal is to degrade DHT (Dihydro-testosterone), which causes male baldness. We are planing to do this by cloning the 3-alpha-HSD gene () from Rat liver origin into E.Coli and B.Subtilis. This enzyme converts the substance into it's inactive and safe form.

    We plan that the bacteria will be applied onto the scalp with a special comb.

    How would your project be used in the real world?
    In a consumer product that ordinary people buy

    Regular lab strains: E.Coli: top10, DH5alpa, BL21
    B.Subtilis: PY79


    There's also on the page the names of the 5 instructors and the 10 students
    ok, so they trick the E.coli into producing a new enzyme which degrades the DHT. this sounds exactly like what we need finally!
    if this would work with a vehicle like the follicept gel this would truely be a revolution in prevention of MPB.
    BUT: could it also have a positive effect on bald skin, too? if you constantly remove the DHT from the miniaturized follicles over many months or even a whole year, would they come to life again?

  3. #13
    Senior Member
    Join Date
    Apr 2015
    Posts
    413

    Default

    Do we know how far along they are? and yeh the E.coli has been modified so that it produces the enzyme to break down DHT. I assume the comb is needed because its an organism so I'm not sure how that will work with follicept. And who knows about the miniaturised follicles. The only time I've seen a nw5 go to nw2 is in transgenders. But I've always thought we have got to a point now where you can inhibit almost all DHT with dutasteride - And I still see people lose hair.

  4. #14
    Senior Member
    Join Date
    May 2015
    Location
    france
    Posts
    395

    Default

    Quote Originally Posted by joachim View Post
    ok, so they trick the E.coli into producing a new enzyme which degrades the DHT. this sounds exactly like what we need finally!
    if this would work with a vehicle like the follicept gel this would truely be a revolution in prevention of MPB.
    BUT: could it also have a positive effect on bald skin, too? if you constantly remove the DHT from the miniaturized follicles over many months or even a whole year, would they come to life again?
    Yes it could sound huge, if this works, it could mean no more DHT in all our follicles. And the 3D printing they're talking is for the perfect vehicle to bring that killer anti dht bacteria into our follicles.

    I hope as you questioned, that it will be capable to help miniaturized to grow back again, but even if not, it will be great also for big Norwoods who want to go the transplant route, and in the future in combination with SM/piloscopy/histogen, etc

    I'm a severe Norwood 4, so if that thing work, and could really slow the baldness, It could convince me to go for a more aggressive HT, and not be scared to become a Norwood 7 in a few years. It could save a lot of us for some years, and help waiting more peacefully the neogenesis cure hehe

  5. #15
    Senior Member
    Join Date
    May 2014
    Posts
    561

    Default

    but wait, they're not going to inject the bacteria itself. the bacteria (e.coli) is used to generate the new enzyme in large amounts, so that the enzyme itself can be injected into the scalp. an enzyme is practically a cluster of different molecules, relatively large in size.
    IGF1 (from follicept) is also made by e.coli. those little bacterial bastards are just used as biological work horses ;-)

    would be interesting for how long these enzymes can last in the scalp, or if they are transported from the blood and going systemic. then of course, we would have the problem that the DHT dissappears from other regions in the body as well. that would be a bad sideeffect. but we don't know nothing about it yet. let's see

  6. #16
    Senior Member
    Join Date
    May 2012
    Posts
    4,423

    Default

    No amount of tinkering with DHT will actually solve the problem. How does something marginally better than finasteride get this much praise?

    Sigh.

  7. #17
    Senior Member
    Join Date
    Jul 2012
    Location
    Canada
    Posts
    1,270

    Default

    LOL

    NEXT

    cmon fg8s get rekt

  8. #18
    Senior Member
    Join Date
    May 2014
    Posts
    561

    Default

    Quote Originally Posted by hellouser View Post
    No amount of tinkering with DHT will actually solve the problem. How does something marginally better than finasteride get this much praise?

    Sigh.
    hasn't the problem of finasteride always been that it lowers scalp DHT only up to 50% or so? it doesn't block it completely, that's the main issue. also the systemic side effects of course. if this technion stuff acts locally only, and can eliminate all DHT, then it's a big deal, no?

  9. #19
    Senior Member
    Join Date
    Feb 2011
    Posts
    497

    Default

    Quote Originally Posted by joachim View Post
    hasn't the problem of finasteride always been that it lowers scalp DHT only up to 50% or so? it doesn't block it completely, that's the main issue. also the systemic side effects of course. if this technion stuff acts locally only, and can eliminate all DHT, then it's a big deal, no?
    Well it could mean something. I mean there is a reason NW7s still have hair on the back of the head. Basically donor region. Those hairs are DHT immune. So if they could immunize us with this comb then it could mean something. Not sure how much it would do with regrowth.

    Not sure if I'm right but iGEM exhibiton is on Sept 24th, am I right?

  10. #20
    Senior Member
    Join Date
    Jul 2015
    Posts
    196

    Default

    This is snake oil. The solution to pattern baldness will come from one of the following sources:

    1. Dr christiano & dr jahoda
    2. Ips cells ( combination of dr. Xu & dr. Terskikh research or dr. Tsuji or other Japanese research teams involved with ips cells)
    3. dr george cotsarelis wounding method along with topical drug combo
    4. US gov't & wake forest collaboration.
    5. Replicel
    6. Shiesheido
    7. Dr. Lauster's team

Similar Threads

  1. igrow comb and super laser comb
    By hopeeman in forum Cutting Edge / Future Treatments
    Replies: 24
    Last Post: 01-29-2015, 06:30 AM
  2. Printed skin with follicles
    By nickk in forum Cutting Edge / Future Treatments
    Replies: 61
    Last Post: 12-15-2014, 03:11 AM
  3. First 3D Printed Liver is Now available to accelertae human trials (Organova)
    By Desmond84 in forum Cutting Edge / Future Treatments
    Replies: 1
    Last Post: 02-08-2014, 07:41 AM
  4. 3D Printed Embryonic Stem Cells
    By hellouser in forum Cutting Edge / Future Treatments
    Replies: 7
    Last Post: 02-13-2013, 01:38 AM
  5. energy comb, VS> factory refurbished hair max comb
    By stylus187 in forum Hair Loss Treatments
    Replies: 10
    Last Post: 01-31-2012, 04:41 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts

» IAHRS

hair transplant surgeons

» The Bald Truth

» Recent Threads

1800 graft repair case results by Dr. Lindsey
Yesterday 08:38 AM
Last Post By Dr. Lindsey
Yesterday 08:38 AM
Navigating the German Job Market as a Kenyan Citizen
11-04-2023 06:31 AM
Last Post By Keegan212
Yesterday 03:51 AM
DR HAKAN DOGANAY/ 4500 GRAFTS / Implanter Pen+FUE
03-26-2024 04:15 PM
Last Post By Hakan Doganay, MD
03-26-2024 04:15 PM
The Mane Event for Thursday, June 15th, 2023
06-15-2023 02:59 PM
Last Post By gisecit34
03-26-2024 08:05 AM