Maybe Replicel will actually be the cure

[luiza]

I know there are already many threads about Replicel but I wanted you guys to comment what you think about it:

http://www.midasletter.com/2014/10/r...rview-podcast/

He is pretty confident that the regrowth will be just a matter of dosage or frequency.
However when I emailed them (Replicel) and got a response they were not so optimistic about the regrowth.

Now there are lots of news coming out claiming that Shiseido has found the baldness cure (Replicel even posted one of them on their FB page):

http://mobile.cosmeticsdesign-asia.c...-says-Shiseido

https://globalcosmeticsnews.com/asia...able-from-2018

http://en.rocketnews24.com/2015/07/0...arket-by-2018/

Also note that it seems they are using iPSCs cells now, which they have never mentioned before. I was wondering if Shiseido has improved Replicel's technology and now we actually have a full cure. That would be awesome.

[JayM]

I really think that ipsc's is important here. We all thought that maybe it was just lost in translation and just a few weeks ago replicel spoke to share holders and didn't mention a difference.

But if they have changed the process would they not need to go through the whole phase 1 again? I mean pilofocus changed a bit of tech and took like a year to get permission to proceed.

I genuinely have no idea aha. Could you email them again and ask about Ipsc's? Since you already received an email?

[Sogeking]

...
He is pretty confident that the regrowth will be just a matter of dosage or frequency.
However when I emailed them (Replicel) and got a response they were not so optimistic about the regrowth.

Now there are lots of news coming out claiming that Shiseido has found the baldness cure (Replicel even posted one of them on their FB page):
..
Also note that it seems they are using iPSCs cells now, which they have never mentioned before. I was wondering if Shiseido has improved Replicel's technology and now we actually have a full cure. That would be awesome.

Yes so far Replicel ,unofficially, through emails to curious parties relayed that their RCH-01 treatment would mostly serve as immunizing solution, meaning halting hair loss. Now they are claiming the cure. I have to warn you though. Various other news sites and sources and at some time even REplicel were hyping the effectiveness of RCH-01 during the times prior to them releasing RCH Phase 1 trials. And then once the results came it was kind of a big disappointment. However even if this only immunizes and halts progression of AGA it will still be valuable as hair loss treatment. We need to wait and see. Thankfully the fast tracked trials for this in Japan should give us some answers soon enough.

As for the iPCs... Well have no idea what that is about. However the sceptic in me thinks that it is too early for making DP cells out of iPSC cells. Guess we'll see.

[FooFighter]

Somebody should write them and ask about iPSCs cells and is this new inovative treatment different from their RCH-01. I am not soo good in english.

[JayM]

Luiza could you do this since you have already spoken to them? Don't worry if you're busy though

[sets]

today replicel on facebook :

Our belief is that injection of our cells are replacing the androgen-sensitive dermal sheath cup cells (responsible for maintaining the cell populations responsible for hair fibre growth) with androgen-insensitive dermal sheath cup cells. In each follicle that this is accomplished we believe the result will be permanent and that what happens is the regeneration of hair growth in that follicle. What is required to halt the progression of the disease is the conversion of each susceptible follicle with androgen insensitive cells.We believe hair regrowth and halting disease progression are both ultimately achievable with our product. In our phase 2 trial we will be testing different doses and multiple injections to determine what works best

[joel203]

When are results from phase 2 data out?

[balding1983]

Yes so far Replicel ,unofficially, through emails to curious parties relayed that their RCH-01 treatment would mostly serve as immunizing solution, meaning halting hair loss. Now they are claiming the cure. I have to warn you though. Various other news sites and sources and at some time even REplicel were hyping the effectiveness of RCH-01 during the times prior to them releasing RCH Phase 1 trials. And then once the results came it was kind of a big disappointment. However even if this only immunizes and halts progression of AGA it will still be valuable as hair loss treatment. We need to wait and see. Thankfully the fast tracked trials for this in Japan should give us some answers soon enough.

As for the iPCs... Well have no idea what that is about. However the sceptic in me thinks that it is too early for making DP cells out of iPSC cells. Guess we'll see.

I am really glad someone here has a good enough memory to remember how Replicel was hyped up before those phase 1 results were released.

All of the recent articles published online including the ones quoted by Replicel on their social network portals are all from obscure blogs and online publications. If there is going to be a genuine cure for baldness it will be on the broadsheets and have decent coverage on the 24 hour news channels. In fact, I heard about the Ramotraban break through on the news not the internet (I visit BTT at least once a day lol).

Secondly, my faith in Replicel actually lessened when they made that announcement about immunising DHT sensitive follicles with their process so that they will be DHT resistant. Think about it. How will they objectively prove that the immunised follicles as being DHT resistant? Patients will have to be followed up for decades to see if their hairloss progresses over time. Have replicel done this or made plans for a longterm follow up study?

Furthermore, the study design will be complicated by the fact that there is no clear way to predict how a man's hair loss will progress with time so you can never tell whether any stopping of hair loss is due to their treatment or innate physiological/genetic factors.

[mlamber5]

I am really glad someone here has a good enough memory to remember how Replicel was hyped up before those phase 1 results were released.

All of the recent articles published online including the ones quoted by Replicel on their social network portals are all from obscure blogs and online publications. If there is going to be a genuine cure for baldness it will be on the broadsheets and have decent coverage on the 24 hour news channels. In fact, I heard about the Ramotraban break through on the news not the internet (I visit BTT at least once a day lol).

Secondly, my faith in Replicel actually lessened when they made that announcement about immunising DHT sensitive follicles with their process so that they will be DHT resistant. Think about it. How will they objectively prove that the immunised follicles as being DHT resistant? Patients will have to be followed up for decades to see if their hairloss progresses over time. Have replicel done this or made plans for a longterm follow up study?

Furthermore, the study design will be complicated by the fact that there is no clear way to predict how a man's hair loss will progress with time so you can never tell whether any stopping of hair loss is due to their treatment or innate physiological/genetic factors.

I think Replicel was basically trying to say that by replacing the balding area dermal cup cells which are bad, with DHT resistant dermal cup cells which are located on the back/side of head, it will work to essentially kickstart the existing follicles back into working because they have the healthy "first initiator" of signals in the healthy dermal cup cells. I think the main problem with this is going to be, after the punch biopsy and multiplication, how to effectively get them to migrate to where the should be upon injecting into bald areas.

[FooFighter]

The main problem about stem cells therapies is that we dont have infrastracture, machines, enough educated people to offer this treatments to big population. Second problem is that we still dont know enough about stem cells. Just look this video

https://www.youtube.com/watch?t=164&v=hw_uOLuTiZI