US government owned patent on hair follicle neogensis - Page 2 - BaldTruthTalk.com
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  1. #11
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    Rajesh Thangapazham, Ph.D., a Research Assistant Professor in the F. Edward Hébert School of Medicine’s Department of Dermatology, USU, was recently selected as a recipient of a 2015 Dermatology Foundation Research Award. Thangapazham will receive the Foundation’s Women’s Health Career Development Award for his project, “Genes Regulating Hair Follicle Neogenesis, Growth, and Development.” Thangapazham and colleagues have shown de novo hair follicle neogenesis in skin substitutes made entirely with cultured human cells. In his proposed work, Thangapazham will investigate molecules hypothesized to enhance the induction of human hair follicles to restore skin function and appearance. This major advance in skin regeneration is predicted to improve skin stability, healing and ultimately lead to a viable clinical strategy for restoring hair.

  2. #12
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    Here is the contact info: Uniformed Services University of the Health Sciences
    4301 Jones Bridge Road
    Bethesda, Maryland 20814

    Administrative Assistant
    Felicia Ballard (link sends e-mail)
    Phone: (301) 295-9802

  3. #13
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    Interesting quotes from "the official us army magazine" regarding 3D print skin graft:

    "In the fight to treat burns and lesions with 3D-printed skin, the US Army has revealed itself as a major contender; as a result of a recent international competition"

    In addition to surgical burn treatment and rehabilitation, the center is participating in several clinical trials to advance skin treatments.
    “We’re currently a part of two major regenerative multi-center trials,” King said. “And they are sponsored in part by the Department of Defense. (Another) group is also (involved), they’re called AFRIM, Armed Forces Institute of Regenerative Medicine — that’s a partnership between the Department of Defense and civilian entities.”

    The two U.S. Food and Drug Administration trials the ISR is participating in are the ReCell and StrataGraft trials. The ReCell trial takes a piece of skin the size of a stamp and uses it to create a solution of individual cells to cover a wound. The StrataGraft trial grows bioengineered skin from stem cell technology, King explained, adding that these skin substitutes are the “holy grail” of burn surgery.

    The StrataGraft project is the most exciting thing we’ve been a part of; it was a phase-two trial, sort of a pilot study to design the definitive phase three, and it is an off-the-shelf skin substitute that has lots of promise in helping revolutionize burn care,”

    "The ISR is also working in parallel with civilian counterparts, developing a potential skin treatment product called a vascularized skin equivalent, which takes amniotic membrane and adds stem cells into a dermal layer to create a skin substitute, similar to StrataGraft, but able to cover a larger surface area, Chung said. "


    All the skin graft world to treat burning is very important for us, as one of the major issue in this field is growing new functional hair follicle after HF neogenesis for the skin acts normally.


    In the articles about skin graft (released about 1 year ago), it said that AFIRM is set to begin 3D bioprinted FDA clinical trials, so they probably already in now.


    And when you see what they claimed in the patent , it's really exciting :

    "The present invention relates to compositions in the form of skin substitutes and microspheres comprising neurai crest-derived mesencyma! cells, such as hair follicle dermal cells, e.g., dermal papilla ("DP") ceils, or dermal sheath cells, that are capable of inducing hair follicles ("HFs"). The present invention also relates to methods, uses, and compositions for inducing HF growth and neogenesis. In some embodiments, the present invention can be used for the treatment of full- or partial-thickness skin loss, wounds, burns, scars, and full- or partia!-hair loss.


    FULL F####g HAIR LOSS ! ))

  4. #14
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    July 2014, A publication of science and technology news from the U.S. Army Research, Development and Engineering Command : http://usarmy.vo.llnwd.net/e2/c/downloads/352196.pdf



    The AFIRM is a multi-institutional, interdisciplinary network of universities, military laboratories and investigators under the framework of a cooperative agreement, Romanko said. The network is designed to promote integration of development, from basic science research through translational and clinical research, as the best means of bringing regenerative médicine therapies to practice.

    “The scars that Soldiers develop as a result of burns constrict movement and disfgure them permanently. The initiative to restore high-quality skin that is elastic and complete with sweat glands, appropriate pigmentation and hair follicles is incredibly important,” he said.

    "The bioprinter deposits each cell precisely where it needs to go, and the cells grow to become new skin. The precision available
    through 3-D bioprinting allows for a custom solution for each patient. “Everyone has a different type of injury, and not everyone’s skin injury looks the same. Skin bioprinting would provide a scalable form of personalized medicine,” Romanko said.

    "About 30 universities, hospitals and additional partners, led by the Wake Forest Institute for Regenerative Medicine, make up the consortium of AFIRM researchers. Romanko works with the TIRM PMO, which supports AFIRM and other regenerative medicine programs. AFIRM receives funding from the U.S. Army, the Offce of Naval Research, Air Force Surgeon General’s Offce, Veterans Health Administration, National Institutes of Health and the Offce of Assistant Secretary of Defense for Health Affairs. AFIRM investigators also bring in funding from other federal, state and private sources." money money money

    "Expanding the technology to a greater number of potential patients will also help to ensure its long-term viability, Romanko said. “This has very widespread use, not only to the military audience, but also to the civilian population. We need a larger commercialization audience in order to be a self-sustaining technology,” he said

  5. #15
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    Do you think you will be able to find this trial on clinicaltrials.gov? I'm not sure what to look for haha. It sounds so promising! If you can print skin with follicles in then surely there's a way just to implant follicles? I don't really need new skin haha.

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    Quote Originally Posted by dutchguyhanging View Post
    Guys.... This is the biggest and most promising news I have ever seen in the last 10 years of my life combating against hair loss. All other solutions on the pipeline are now on the sideline.
    I have my utmost trust on US Military Medicals as they have by far the best technology.
    This.

    Quote Originally Posted by dutchguyhanging View Post
    The only question is 1- They would keep it highly confidential since its military. But we need to know when they are planning to lunch so it would become mainstream for everyone of us.
    And this. We talk about the military here. The obvious and utmost interest is to rehabilitate their injured soldiers. It is unknown if and when such techniques will go outside the military medical field.

    U.S. Army is the only force in existence at this moment that can really do something about tissue regeneration with practical applications. All other players, discussed so much in this forum, are ants in front of them. But, again, the big question is if and when the general public will benefit from such biotechnological progress. And don't hope to learn anything more than what it is publicly available by directly contacting them.

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    The thing is though as lacazette mentioned they will be looking to expand it to the general public because they will need to make money on it at some point - Better than selling guns ay

    We all know that the DOD in many countries like to be secretive but it wouldn't really need to be the case here. And once they start performing these on a bigger scale you will need to outsource and it comes to a point where the public would have a right to access the care - Even if its insanely priced. An insane amount of things we have access to today are from the military and most advances aren't withheld.

  8. #18
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    Yes they say to have a succesful skin graft, the major issues were skin with sweat glands, appropriate pigmentation, and hair follicles. And fully functional hair follicle is the crucial factor that current skin graft are missing.

    They say their invention fills these needs
    And in the patent they mention a lot about hair loss:
    "that are capable of inducing hair follicles" "The present invention also relates to methods, uses, and compositions for inducing HF growth and neogenesis"

    " the present invention can be used for the treatment of full- or partia!-hair loss. " full !!!

    " In addition, hair restoration is one of the fastest growing areas of cosmetic therapies for both men and women. "

    "Such methods and compositions would be useful for treating conditions such as full- or partial-thickness skin loss, wounds, burns, scars, and hair loss. The present invention fills these needs by providing cellular compositions capable of hair growth, neogenesis, and regeneration.


    "The present invention is capable of inducing hair follicles that are morphologically-correct and are useful in any application requiring hair follicle formation/neogenesis, or in any condition where hair follicle formation/neogenesis is desired"

    "methods for transplanting cells at therapeutically effective concentrations capable of inducing human hair follicles "
    "the transplanted cells can be used to induce hair follicle growth or hair follicle neogenesis."

    " the subject to be treated with any of the compositions or methods described above has a partial- thickness skin loss, full-thickness skin loss, a wound, a burn, a scar, or hair loss. "

    All these quotes are just from the first 1/4 of the patent, so us hair loss sufferers will benefit from these progress
    Yeah jay haha we don't need a complete new skin ^^ we 're are Lucky compared to severe burned face.

    Well they have found what cotsarelis and follica are trying to do for years ( and it's logical as US army have unlimited money, best technologies and researchers, and burned injuries and skin loss are the most important issues in soldiers nowadays)

    And what is good also is that AFIRM is in collaboration with civil entities, and that quote is very hopeful to me :
    “This has very widespread use, not only to the military audience, but also to the civilian population. We NEED a larger commercialization audience in order to be a self-sustaining technology,”

    And as you said, we won't need a complete new skin, just the compositions/methods for functional hair growth/neogenesis and they claimed to have them!

    US army research is in the neogenesis game and it's incomparable with little private companies as follica,theracell,etc

    Sounds too exciting to be true lol

  9. #19
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    " In addition, hair restoration is one of the fastest growing areas of cosmetic therapies for both men and women. "

    This is the most important sentence for me. It shows that this therapy isn't just for burn victims or people who need skin grafts and wont just be used in the military. It shows that they plan to expand and offer this to the public.

    Talking about Cotsarelis, do we know if any of these scientist worked with him before? Could be a possibility. Or maybe he just gave up the game because he was piped to it by US army?

    @hellouser you know a lot about his research any insight?

  10. #20
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    I agree, Jay, there's a lot of hairloss references in the patent and it claims many times (in short): 'this invention is useful to treat FULL hair loss'.
    So they know it will not be useful just for skin grafts on burned patients, and the sentence you quote about hair industry just proove that thing.
    they know they have gold in their hand, for sure.

    other interesting quotes:

    "methods are disclosed herein for transplanting cells capable of inducing human hair follicles to a subject, comprising delivering to a human subject any of the microspheres described above. In some embodiments, the microsphere is subdermally or intradermally delivered to a subject."
    two approaches to deliver the cells that will induce human HF

    "Also disclosed herein are the microspheres described above for use in the manufacture of a medicament for inducing hair follicle formation or for inducing hair follicle neogenesis in a subject
    "

    those little quotes are good also, they talk about anagen,telogen,etc, their hair are cycling and are morphologically-correct

    "Fig. 15B provides a magnified view showing the presence of pigmented hair shafts."

    "after 15 weeks, Figs. 16A-C show telogen hair follicles, confirmed by club-like appearance and spiky keratin fibers(Fig. 18A), secondary hair germ with adjacent hair papilla (Fig. 16B), and presence of a cornified club "

    "Fig. 17B shows an anagen hair follicle with dermal papilla (arrow), including dense Ki- 67 reactivity. "


    [059] In some embodiments, a subject in need of inducing hair follicle growth has partial-thickness skin loss, full-thickness skin loss, a wound, a burn, a scar, or hair loss...

    I just stop at the middle of the patent, but all I read in it for the moment is just what I was dreaming to read for years hehe

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