Could a partnership Samumed/Follica = the cure ?

[lacazette]

- Follica have their wounding procedure, They seem to fail (not to create neogenesis but to find that exact molecule that would create functional new follicle

"It turns out that the wound-healing process causes skin cells to dedifferentiate, providing a limited time window during which those cells can be persuaded to form new hair follicles.The researchers also found that inhibiting Wnt signaling during this window reduced follicle neogenesis, while overexpressing Wnt molecules in the skin increased the number of new follicles"

-Samumed is specialize in Wnt pathway, and they peraph's already have the knowledge and capacity to create that kind of Wnt molecule that could induce neogenesis and then a hair with good characteristics
If they don't, that kind of Wnt pathway is probably not far far away from their initial molecule for MPB currently in trial

Please god tell Cotsarelis to ask some help and collaboration! a great solution could be not that far away (of course a lot of years of clinical trials, but that would be a real cure in the horizon and we could already live with more peace in our mind hehe)

[nameless]

You said, "-Samumed is specialize in Wnt pathway, and they peraph's already have the knowledge and capacity to create that kind of Wnt molecule that could induce neogenesis and then a hair with good characteristics
If they don't, that kind of Wnt pathway is probably not far far away from their initial molecule for MPB currently in trial"

What does this mean? I can't make sense of it. Were you drunk when you wrote it.

[hellouser]

Could a Lauster/Jahoda partnership = the cure?
Could a Bimatoprost/Setipiprant partnership = the cure?
Could a Follica/Histogen partnership = the cure?
Could a Histogen/Replicel partnership = the cure?

[Ziggyz123]

Could a Lauster/Jahoda partnership = the cure?
Could a Bimatoprost/Setipiprant partnership = the cure?
Could a Follica/Histogen partnership = the cure?
Could a Histogen/Replicel partnership = the cure?

Yeah, too many coulda, woulda, shoulda's.. Who the hell knows when or who will cure hairloss let alone treat it. It's a selfish industry and optimism is getting extremely exhausting.

[noisette]

Wnt1a maintains characteristics of dermal papilla cells that induce mouse hair regene

And this could be the cure?

Wnt1a maintains characteristics of dermal papilla cells that induce mouse hair regeneration in a 3D preculture system.
Article in Journal of Tissue Engineering and Regenerative Medicine · June 2015


Abstract
Hair follicle morphogenesis and regeneration depend on intensive but well-orchestrated interactions between epithelial and mesenchymal components. Therefore, an alternative strategy to reproduce the process of epithelial-mesenchymal interaction in vitro could use a 3D system containing appropriate cell populations. The 3D air-liquid culture system for reproducibly generating hair follicles from dissociated epithelial and dermal papilla (DP) cells combined with a collagen-chitosan scaffold is described in this study. Wnt-CM was prepared from the supernatant of Wnt1a-expressing bone marrow mesenchymal stem cells (BM-MSCs) that maintain the hair-inducing gene expression of DP cells. The collagen-chitosan scaffold cells (CCS cells) were constructed using a two-step method by inoculating the Wnt-CM-treated DP cells and epidermal (EP) cells into the CCS. The cells in the air-liquid culture formed dermal condensates and a proliferative cell layer in vitro. The CCS cells were able to induce hair regeneration in nude mice. The results demonstrate that Wnt-CM can maintain the hair induction ability of DP cells in expansion cultures, and this approach can be used for large-scale preparation of CCS cells in vitro to treat hair loss.
Copyright © 2015 John Wiley & Sons, Ltd.

[lacazette]

You said, "-Samumed is specialize in Wnt pathway, and they peraph's already have the knowledge and capacity to create that kind of Wnt molecule that could induce neogenesis and then a hair with good characteristics
If they don't, that kind of Wnt pathway is probably not far far away from their initial molecule for MPB currently in trial"

What does this mean? I can't make sense of it. Were you drunk when you wrote it.

I wanted to say that Samumed have better knowledge than cotsarelis on how modulate Wnt pathway with a small molecule, and the capacity of create that molecule . ( they already are in phase 2 for mpb, and phase 1 for a pill destinate to cancers patients in final phase, so in my opinion they have better capacities to create what Cotsarelis is missing) Doesn't make sense?

Well i supposed Follica is failing, maybe not and they're doing their thing under the radar, but in supposition they're failing, I really think Samumed could find the molecule to apply after the wounding skin procedure (and they maybe already have that knowledge since pathway modulating is their only work domain!)
, when you see that they were taking only Nwd 4,5,6,7 in their 300 patients for phase 2 trial, it gives me hope that they know a lot on Wnt pathway and have powerful drugs, and not that 'early stage of baldness' bullshit

And yes I make weird sentences formulations cause it's not my native langage

[JayM]

Better English than me and I'm British haha!

[brocktherock]

And this could be the cure?

Wnt1a maintains characteristics of dermal papilla cells that induce mouse hair regeneration in a 3D preculture system.
Article in Journal of Tissue Engineering and Regenerative Medicine · June 2015


Abstract
Hair follicle morphogenesis and regeneration depend on intensive but well-orchestrated interactions between epithelial and mesenchymal components. Therefore, an alternative strategy to reproduce the process of epithelial-mesenchymal interaction in vitro could use a 3D system containing appropriate cell populations. The 3D air-liquid culture system for reproducibly generating hair follicles from dissociated epithelial and dermal papilla (DP) cells combined with a collagen-chitosan scaffold is described in this study. Wnt-CM was prepared from the supernatant of Wnt1a-expressing bone marrow mesenchymal stem cells (BM-MSCs) that maintain the hair-inducing gene expression of DP cells. The collagen-chitosan scaffold cells (CCS cells) were constructed using a two-step method by inoculating the Wnt-CM-treated DP cells and epidermal (EP) cells into the CCS. The cells in the air-liquid culture formed dermal condensates and a proliferative cell layer in vitro. The CCS cells were able to induce hair regeneration in nude mice. The results demonstrate that Wnt-CM can maintain the hair induction ability of DP cells in expansion cultures, and this approach can be used for large-scale preparation of CCS cells in vitro to treat hair loss.
Copyright © 2015 John Wiley & Sons, Ltd.

Whaaaaaaaaaaaaaa? So that's it?

[lacazette]

HAha JayM x)

To add something about Sm drug, look what sarah millar was saying in 2013 :

"However, stem cells were still maintained within the dormant hair follicles. When Dkk1 was removed, the Wnt/β-catenin pathway resumed normal function, the stem cells were activated, and hair growth was restored.
While more research is needed to improve our understanding of this pathway, our results suggest that if delivered in a limited, safe and controlled way, agents that activate Wnt signaling might be used to promote hair growth in dormant hair follicles in conditions such as male pattern baldness,” said senior author Sarah Millar, PhD, professor in the departments of Dermatology and of Cell and Developmental Biology.

Researchers aim to better understand the key components and functions of the Wnt/β-catenin pathway. Important areas of focus for future work will include developing effective means of safely targeting therapeutics to the skin for clinical and cosmetic applications. "

Sounds like SM04554, no?

If it is, that would mean Samumed was in advance of follica's team in understanding the right pathway and how modulate it with the right smalls molecules and went into clinical trials even before Sarah millar publish this study.
So Hellouser I don't think it's that absurd when I say that Samumed could be in advance in that 'wnt pathway world', and could already have the knowledge to create the molecule that Cotsarelis is missing after is wounding procedure

[nameless]

And this could be the cure?

Wnt1a maintains characteristics of dermal papilla cells that induce mouse hair regeneration in a 3D preculture system.
Article in Journal of Tissue Engineering and Regenerative Medicine · June 2015


Abstract
Hair follicle morphogenesis and regeneration depend on intensive but well-orchestrated interactions between epithelial and mesenchymal components. Therefore, an alternative strategy to reproduce the process of epithelial-mesenchymal interaction in vitro could use a 3D system containing appropriate cell populations. The 3D air-liquid culture system for reproducibly generating hair follicles from dissociated epithelial and dermal papilla (DP) cells combined with a collagen-chitosan scaffold is described in this study. Wnt-CM was prepared from the supernatant of Wnt1a-expressing bone marrow mesenchymal stem cells (BM-MSCs) that maintain the hair-inducing gene expression of DP cells. The collagen-chitosan scaffold cells (CCS cells) were constructed using a two-step method by inoculating the Wnt-CM-treated DP cells and epidermal (EP) cells into the CCS. The cells in the air-liquid culture formed dermal condensates and a proliferative cell layer in vitro. The CCS cells were able to induce hair regeneration in nude mice. The results demonstrate that Wnt-CM can maintain the hair induction ability of DP cells in expansion cultures, and this approach can be used for large-scale preparation of CCS cells in vitro to treat hair loss.
Copyright © 2015 John Wiley & Sons, Ltd.

They are talking about nude mice. Mice. This does not mean it will work in humans.

[lacazette]

Another study by other researchers in 2013 regarding Wnt signals:

http://www.nature.com/jid/journal/v133/n1/full/jid2012446a.html

"Activation of β-catenin was shown to be of central importance for hair development and cycling. Recent progress brought more understanding to how Wnt signaling is regulated during hair follicle generation and regeneration, telogen–anagen reentry, and extra-follicular macro-environmental modulation. This new understanding presents multiple possibilities to fine tune Wnt signaling for desired hair growth."

To manage these clinical conditions, it is important to understand molecular pathways that regulate the number, size, growth, and regeneration of hair follicles. Wnt signaling has a fundamental role in this process. We need a deeper understanding so that we can reliably adjust Wnt levels in existing follicles. In sum, the studies reviewed here have future translational value for skin regeneration following severe wound injury and in the context of tissue engineering. Tuning the levels of Wnt ligands can modulate the number and growth of hairs directly. On the basis of this new knowledge, we now know that Wnt activity can be modulated by adjusting the secretion of Wnt ligands, altering binding of ligands to receptors, inhibiting β-catenin translocation, or by regulating extrafollicular dermal Wnt and Wnt inhibitors. "


In 2013 it was on mouse studies, now 2015 it's on humans trials phase 2 #IamSamumed haha

[macbeth81]

Their original patent, under company name Wintherix, was filed in 2011. With regard to hair loss, they referenced a paper in 2008. That 2013 paper was probably old news for them.

[lacazette]

2 june 2015 : http://otl.sinica.edu.tw/en/index.ph...article_id=858

"Preparation of skin extract for hair follicle neogenesis"

"We screened and successfully identified protein extract and a ****tail of specific protein mixtures that are able to induce hair follicle neogenesis "

"With this technology, hair follicle neogenesis can be induced without expansion of hair follicle dermal papilla cells from the patients. The cost can be reduced."

"Protein extract or ****tail of specific proteins can be used in (A) As a drug for local administration to induce hair follicle neogenesis; (2) Preparation of bioartificial dermis or bioartificial skin: addition of the extract in bioartificial skin or bioartificial dermis can induce hair follicle neogenesis; (3) In vitro cell culture: addition of this recipe to cultured fibroblasts can confer the fibroblasts trichogenic capability."

[hosney7]

Is it can be the cure? Sung jan lin is quite prominant in eastern area
last month he came to Korean dermatology congress and had presentation about hair regeneration
The presentation is restricted to the dermatologist that I don't have more info
anyway considering their previous researches, it is worth for us to keep watching his research. I think he can bring us 'the cure'

[FooFighter]

2 june 2015 : http://otl.sinica.edu.tw/en/index.ph...article_id=858

"Preparation of skin extract for hair follicle neogenesis"

"We screened and successfully identified protein extract and a ****tail of specific protein mixtures that are able to induce hair follicle neogenesis "

"With this technology, hair follicle neogenesis can be induced without expansion of hair follicle dermal papilla cells from the patients. The cost can be reduced."

"Protein extract or ****tail of specific proteins can be used in (A) As a drug for local administration to induce hair follicle neogenesis; (2) Preparation of bioartificial dermis or bioartificial skin: addition of the extract in bioartificial skin or bioartificial dermis can induce hair follicle neogenesis; (3) In vitro cell culture: addition of this recipe to cultured fibroblasts can confer the fibroblasts trichogenic capability."

Someone from Asia should call or write them.

Contact Person： Ivy Yang, Tel:886-2-2787-2502 E-Mail: ivyy@gate.sinica.edu.tw