Donor Regeneration

[Swooping]

Interesting. I was surprised by the Italian study actually that a horizontal split could regenerate hair follicles even if they grow thinner/smaller. Basically that means that also the bulge is capable of generating de-novo morphogenesis. I'll go over the whole study this week. The possibility is there no doubt, some problems I foresee though;

- Speed. Assuming the hair follicle could be split with a "harsh" cut either through a horizontal axis or vertical axis this shouldn't be a problem. However if it is really needed to properly dissect cell lines from each other that is going to be pretty damn time invasive under a microscope. Time means money. It isn't a realistic scenario to work 10 minutes per graft. It would be hugely expensive and no way the hair transplant industry would innovate on such a thing even if the possibility would be there? They are pretty damn protective already.

- Harsh environment recipient. This is another problem. Normal FUE survival rates assuming you go with a good surgeon are 90%+. When you cut a hair follicle you basically induce mechanical trauma. This means that the tissue itself is already broadly way more susceptible to environmental stress and oxidation stress outside of the body. One would almost have to ensure that the splitted hair follicle would be needed to be place back as soon as possible into the recipient. However the recipient itself is a problem also indeed as Gardner said. This isn't exactly a embryogenesis environment. There are indeed many bad factors expressed in bald scalp. No wonder that even with normal FUE when you induce mechanical trauma to the hair follicle even a fully intact hair follicle can easily fail to grow. FUE is just so good nowadays because the transection rates are very low and subsequently good mediums like hypothermosol + ATP are used and delicate handling is performed. Overall the best surgeons just have everything lined out in an excellent protocol.

Nonetheless these are all things that can probably be tweaked. And the good thing about it all that with such practice you can work in vivo with direct observational experience. This is the best thing you can do/have in science. Plus you can work on humans, not on mice .

FearTheLoss do did you watch the bald truth? Do you have a recap of what Dr. Wesley said there?