@bbbeeeppp3
It is possible to reverse damage and to regrow hair in androgenetic alopecia. I have gone myself NW4 to NW2 with treatments (Now a NW1 though). I have seen reversal of androgenetic alopecia to great extent and sometimes full. It's also known in literature. It's just not common at all. Estrogen + castration is the best method known of sometimes causing (full) reversal of androgenetic alopecia.
Anyway there are all different forms of hairloss
- Androgenetic alopecia (reversible)
- Alopecia areata (reversible, auto-immune, mechanism fully understood)
- Scarring Alopecia's (irreversible, fibrosis & scarring)
- Senescence (aging) alopecia (unknown)
To answer your question though why it is so difficult. There is one answer; nobody full understands yet. However multiple researchers are pointing out extremely hard evidence lately to important factors which are implicated in androgenetic alopecia;
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828374/
- http://www.ncbi.nlm.nih.gov/pubmed/17989730
- http://www.ncbi.nlm.nih.gov/pubmed/18702626
- http://www.ncbi.nlm.nih.gov/pubmed/25647436
- http://www.papersearch.net/view/deta...l_key=27731029
There are like 3 or 4 more studies of other researchers who point out the same problems. Anyway you don't need to read them as they might be hard to understand. I can translate it to you in a simple manner though. Your hair follicle consists of different types of cells. Your whole body does. Every cell is a little organism, literally a working horse. Every cell can decide his own cell fate. A cell can decide to profilerate, they can die (apoptosis), and they can also lock itself (senescence). Among some other actions.
Now your hair follicle consists of a extremely important type of mesenchymal type of cells. These cells initially kind of made your whole hair follicle when you were in the embryogenesis state. These cells are called the dermal papilla. They can be seen as a master regulator of the hair follicle. I don't exactly remember how much dermal papilla cells there are present in every hair follicle but I think the number was 500. They are the mastor regulator of the hair follicle basically. They also harness the androgen receptors of the hair follicle.
Now I think you already know androgens are bad. Imagine now the androgens coming through the blood attaching to the androgen receptor to the dermal papilla. These 500 cells of the dermal papilla receive that signal. However in a person with androgenetic alopecia something is causing them to get stressed out like hell. The researchers refer to this as "oxidative stress" & "dna damage" in the studies I just showed you. You remember that I mentioned that cells can decide their own cell fate right? Well so these researchers point out that these cells react to this stress. After all prolonged stress isn't good at all for cells and they adapt in an efficient manner. What do they do? Every cell individually at a certain moment has had enough of it and goes in a permanent lock of cell arrest. That's how they shield itself from the stress from preventing further damage. Problem is this lock is extremely hard to unlock. They locked itself down for a reason and the pathways responsible for this are a extremely important function of the cells in your body. Without them you wouldn't survive. This mechanism also protects you from oncogene (cancer) transformation for example.
Now the fun thing is remember; estrogen? Estrogen has impact on these pathways and can override this cell fate lock. A fun fact is also with that that estrogen is seen as a cancerous compound. There is way more proof for these researchers that this really seems to be the problem. This is also the case when you observe AGA. For instance the amount of dermal papilla cells correlate with hair size. So if you have 500 dermal papilla cells in a normal cell fate you have a fully terminal hair. However when some of these cells decide to die or adopt a state of cell arrest your hair follicle get's smaller.
Anyway that's it in a nutshell. You can basically kinda view androgenetic alopecia like premature aging of the cells. I can only give you one tip furthermore; Try to work with the current treatments we have. The outlook for the coming 10 years is pretty bad to give better options than we have currently. You can come very far with current methods too. Take the matter in your owns hands. Wishing & hoping for better treatments is a joke. Most likely it isn't going to come short-term or mid-term. Good luck!
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