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Safety and efficacy analysis of liposomal insulin-like growth factor-1 in a fluid gel formulation for hair-loss treatment in a hamster model.
Castro RF1, Azzalis LA, Feder D, Perazzo FF, Pereira EC, Junqueira VB, Rocha KC, Machado CD, Paschoal FC, Gnann LA, Fonseca FL.
Author information
1Discipline of Dermatology, Department of Clinical Medicine, Faculty of Medicine ABC, Santo André, SP, Brazil.
Abstract
Insulin-like growth factor (IGF)-1 has shown some interesting results in studies examining its use as a hair-loss treatment. IGF-1 works by regulating cellular proliferation and migration during the development of hair follicles. Hepatotoxicity and myelotoxicity were evaluated in hamsters (Mesocricetus auratus) after topical application of the liquid gel vehicle (placebo), 1% IGF-1 or 3% IGF-1. No significant difference in the levels of aspartate aminotransferase or alanine aminotransferase was found between the control and treated groups. ELISA did not shown any increase in the plasma level of IGF-1. A haematopoietic niche was found, but it was not associated with myelotoxicity. Efficacy was determined by dermatoscopy analysis of hair density and microscopy analysis of hair diameter, with hair found to be thicker and with more rapid growth in the 3% group than in either the 1% group or the control group. These results strongly suggest that liposomal IGF-1 in a liquid gel formulation is a safe and efficient treatment for hair loss.
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When can it be purchased?
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Originally Posted by rambo007
reading the test examples in this link makes this stuff sounds pretty good...
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The real question is to know if this product will provide more regrowth than minox !
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Originally came in to mock it as snake oil, but it honestly doesn't sound like bullhockey. Could be a cool supplemental thing. I might give it a shot.
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Originally Posted by Gerhard
Originally came in to mock it as snake oil, but it honestly doesn't sound like bullhockey. Could be a cool supplemental thing. I might give it a shot.
Same here, but I like their confidence.
"We will send you exactly one email: to let you know when and where to get the product when we are ready. It will be soon. No spam, no games"
I like that.
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Hopefully it'll be available in Europe too.
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They're marketing it as a growth stimulant more than a Androgen inhibitor... This has me worried because the science posted by Recidive says the opposite.
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Looks like they just updated their website with a FAQ. http://www.hairgrowthsoon.com/#faq
There is a link with an explanation here: https://www.dropbox.com/s/ls05w87bt5...eview.pdf?dl=0
The second line of that PDF states "The condition is characterized by below normal levels of androgens such as dihydrotestosterone (DHT), testosterone, FSH, and sex hormone binding globulin at the dermal papillae."
Additionally, there is a diagram with a pathway specifying the function of IGF-1.
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Originally Posted by Reign
Looks like they just updated their website with a FAQ. http://www.hairgrowthsoon.com/#faq
There is a link with an explanation here: https://www.dropbox.com/s/ls05w87bt5...eview.pdf?dl=0
The second line of that PDF states "The condition is characterized by below normal levels of androgens such as dihydrotestosterone (DHT), testosterone, FSH, and sex hormone binding globulin at the dermal papillae."
Additionally, there is a diagram with a pathway specifying the function of IGF-1.
On the other hand, it's just a start-up from a biology student...
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