OC info+ use RU at your own risk

[unbalding]

I think honestly the best option is to follow researchers' lead and use what they think works, which is setipiprant. Otherwise OC seems to be a good candidate, as we know it can be made, sold, and used topically with success, though anecdotal. I do not need photo proof to buy it at a reasonable price. The science is there, the reports of it working are enough, and I have had enough of a change in shedding and itch with zyrtec alone that Im pretty positive this will work. If it doesn't then I simply won't buy any more. The health risks are basically nil. I don't know anything about TM, or if it targets the exact receptor that cots has implicated and linked to treatment with setipiprant.

People are overlooking the obvious reason that Kythera went with setipiprant. It was the most available option, that is, they were able to buy the rights to it. I think they would have preferred OC or TM if they could have acquired the rights to either one.

TM does target the same CRTH2 receptor as setipiprant and OC, only it is more selective and more effective. It completely blocks PGD2 from the receptor without affecting other receptors. The only concern, as Gerhard pointed out, is that we don't know the effects of completely blocking PGD2. Although being more selective should make it safer to the extent that OC and setipiprant target other receptors. Other than that, TM is soluble in water. High concentrations of OC are only soluble in DMSO. TM only needs to be applied once a day at the most, and perhaps less.