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Setipiprant
http://www.chemicalbook.com/Chemical...CB52683701.htm
Can possibly obtain setipiprant from this source. This drug has been tested pretty thoroughly for safety already, so someone with loot get on this and try it out! I wouldn't expect a lot of regrowth, but who knows what's possible, and should at least be good for maintenance. If we can get a reliable source then maybe we can also find ways to use it topically and not wait the whatever number of years for this to be put through the wringer. Filing an IND alone is gonna take at least a year.
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Originally Posted by sdsurfin
http://www.chemicalbook.com/Chemical...CB52683701.htm
Can possibly obtain setipiprant from this source. This drug has been tested pretty thoroughly for safety already, so someone with loot get on this and try it out! I wouldn't expect a lot of regrowth, but who knows what's possible, and should at least be good for maintenance. If we can get a reliable source then maybe we can also find ways to use it topically and not wait the whatever number of years for this to be put through the wringer. Filing an IND alone is gonna take at least a year.
Just wait until it is formulated correctly for hairloss, cant just buy raw product, slap it on and live happily ever after. For all you know, product can be bust or not handled correctly
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Also look at this
Hair grows as normal when PGD2 blocked!! human hair!!
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And when will it be available on the real market ?
And same question for the "black market" ?
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Yeah speed is definitely not the strength of the FDA. That being said this stuff is the most promising thing for MPB in the last 20 years IMO but I would feel better seeing a little more evidence to how well it works. CB, BIM and this in the next 5 years? MPB would be toast.
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Excuse me guys for being ignorant of this drug - But can anyone link me to information about side effects, etc?
EDIT: http://www.ncbi.nlm.nih.gov/pubmed/24095247
Results
All subjects completed the study. Both formulations were well tolerated, with headache the most frequently reported adverse event (25% of subjects), followed by flatulence (15%) and somnolence and fatigue (10%). The adverse event profile in men and women and between formulations was similar. The ratios of geometric means for Cmax (0.94; 95% CI, 0.79-1.12) and AUC0-∞ (1.01; 95% CI, 0.92-1.12) were mostly within the limits of 0.80 to 1.25. When corrected for weight, the differences observed between sexes, within each treatment, for Cmax (capsules: 1.01; 95% CI, 0.71-1.44; tablet: 0.89; 95% CI, 0.62-1.26) and AUC0-∞ (capsules: 1.12; 95% CI, 0.86-1.47; tablet: 0.96; 95% CI, 0.73-1.25) were minor.
So this one doesn't interfere with androgen's I take?
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Originally Posted by HairlossAt15
Also look at this
Attachment 37431
Hair grows as normal when PGD2 blocked!! human hair!!
This is interesting. Can you please say where it came from?
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Originally Posted by beetee
This is interesting. Can you please say where it came from?
kythera's presentation on the development of this drug for hair loss, page 7:
http://files.shareholder.com/downloa...0Deck%209FEB15
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Originally Posted by Trenblastoise
Excuse me guys for being ignorant of this drug - But can anyone link me to information about side effects, etc?
EDIT: http://www.ncbi.nlm.nih.gov/pubmed/24095247
Results
All subjects completed the study. Both formulations were well tolerated, with headache the most frequently reported adverse event (25% of subjects), followed by flatulence (15%) and somnolence and fatigue (10%). The adverse event profile in men and women and between formulations was similar. The ratios of geometric means for Cmax (0.94; 95% CI, 0.79-1.12) and AUC0-∞ (1.01; 95% CI, 0.92-1.12) were mostly within the limits of 0.80 to 1.25. When corrected for weight, the differences observed between sexes, within each treatment, for Cmax (capsules: 1.01; 95% CI, 0.71-1.44; tablet: 0.89; 95% CI, 0.62-1.26) and AUC0-∞ (capsules: 1.12; 95% CI, 0.86-1.47; tablet: 0.96; 95% CI, 0.73-1.25) were minor.
So this one doesn't interfere with androgen's I take?
Hi i'm thinking of getting in on a Seti GB, but something baffles - there have been 8 clinical trials with over 1000 patients and then with 211 using 1000mg (see link below), how come it wasnt noticed or reported that Seti caused any positive influence to hair loss as as a side-effect from these trials? Admittedly, of the 211 only a say, 10% - 20% will have AGA, but still, that's 21 to 42 patients.
I would have thought it would have been spotted (like fin when initially only used for prostate cancer, or minox etc) and jumped on by pharma from the headlines rather than Cotsarelis's unrelated research that PGD2 inhibition should limit hair loss and then Seti being identified as an strong inhibitor and thus should work leading to a trials etc
Thoughts?
http://files.shareholder.com/downloa...tipiprant_.pdf
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I thought this exact thing however, it is probably because setipiprant isn't going to regrow hair. It's ping to be for halting hairloss. It is puzzling however like you say that propecia regrew hair.. You'd think that seti would be even better. However, seti could possibly rejuvenate hair that was on its way to miniaturization. I'm in the group buy and have paid. I was thinking of just trialing seti at 1000mg til I run out so 25 days lol. But just to see if this halts shedding and what not so that we know if seti is a dead end.
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