CB-03-01 Investor update

[huawei]

Looks pretty reasonable really though I don't see the comparisons to current stuff like propecia. IIRC looking at this the other day this aims to treat the effects of inflammation rather than the underlying cause of inflammation where as propecia actively reduces the inflammation through reduction in dht and all of that yeah? Still if this comes to the market it'll be a welcome addition.

[burtandernie]

Its an AA first and foremost but it has anti inflammatory properties too so it might work better than propecia. Its all guessing until we see this phase 2 which will tell the real story. How big is the anti inflammatory part of it? No one knows so just wait and see. Guessing at how well it works is kind of silly. The preliminary study said 2 times as strong as propecia.

[It's2014ComeOnAlready]

Its an AA first and foremost but it has anti inflammatory properties too so it might work better than propecia. Its all guessing until we see this phase 2 which will tell the real story. How big is the anti inflammatory part of it? No one knows so just wait and see. Guessing at how well it works is kind of silly. The preliminary study said 2 times as strong as propecia.

Propecia needs to just die as the leading hair loss treatment. It's absurd that in 2015, the best we can do is Propecia.

[sdsurfin]

it's actually not an anti androgen first and foremost. It's a compound with anti androgen properties, but there are other much better anti androgens currently being tested for acne. the problem is theres no guarantee they will ever be tested for AA and if they are it will be a long time from now. it really sucks. CB is very hyped, and according to people at companies i've talked to is not that powerful. Might still be useful but wouldn't count on too much.

[balding1983]

The reason they don't test anti-androgens first for AA and instead for things like acne is because of potential markets.
Would a teenager be willing to use a new treatment for acne if they know it is being used to make bald men hairy?

But if a drug corners the acne market first and then the company can bring out that same drug for AA without reducing their potential market.

[hellouser]

Propecia needs to just die as the leading hair loss treatment. It's absurd that in 2015, the best we can do is Propecia.

Careful! Some guys might find this type of criticism offensive and will tell you we've made great progress with hair loss in the last 20 years...

LOL

[FearTheLoss]

The reason they don't test anti-androgens first for AA and instead for things like acne is because of potential markets.
Would a teenager be willing to use a new treatment for acne if they know it is being used to make bald men hairy?

But if a drug corners the acne market first and then the company can bring out that same drug for AA without reducing their potential market.

This is completely inaccurate. The reason is because it costs 10x as much to run trials for AGA.

[sdsurfin]

This is completely inaccurate. The reason is because it costs 10x as much to run trials for AGA.

yup. hair trials take much longer. And the market for acne actually is bigger whether you can believe it or not. Pretty much everyone gets acne. Has nothing to do with what the other dude above said at all. The lady from Hygeia laid it out pretty succinctly earlier. It's just crazy that all of this hasn't already happened, these topical anti androgens have been known forever. Propecia is the worst thing to have ever happened to hairloss research.

[LMS]

yup. hair trials take much longer. And the market for acne actually is bigger whether you can believe it or not. Pretty much everyone gets acne. Has nothing to do with what the other dude above said at all. The lady from Hygeia laid it out pretty succinctly earlier. It's just crazy that all of this hasn't already happened, these topical anti androgens have been known forever. Propecia is the worst thing to have ever happened to hairloss research.

Careful with taking the words of a competing company for absolute truth brotha

[Pate]

Not much to say, they expect to finish Phase 3 for acne with CB-03-01 by the end of 2017. And it shows great promise without serious side effects. The vehicle is BID 1% (don't know what this is).

For alopecia they are taking NW2 - NW5s, mostly NW3 and NW3 vertex to see the results of CB vs. placebo and minox. Phase 2 should finish by the end of this year.

BID 1% is not the vehicle. BID means bis in diem which is Latin for twice a day. It's standard pharma terminology.

So they are applying 1% CB twice a day.

Re: CB's strength, it doesn't really matter that CB is a slightly weaker AA than others. That just means you may need a higher concentration. The important thing is what happens when it penetrates the skin ie it supposedly quickly degrades to an inactive form. Unlike say flutamide which is a very strong AA but has systemic effects.

I don't recall Cosmo ever saying CB causes massive new hair growth. The pilot study showed an increase in hair count but that doesn't mean new hairs, it just means more hairs in anagen, which means more hairs at any given time. It won't cause much new growth anyway. AAs do not grow new hair. They don't even really reverse miniaturisation except in very early or very rare cases. It should significantly outperform Propecia though, because Propecia only lowers scalp DHT by about 30%. CB should beat that comfortably, and block T as well as DHT.

The best way to think of CB is basically the same as RU but more stable. And also quality control assured of it gets released officially.