Azelaic Acid. Does it work?

[warner8]

Any users have any positive reviews about this stuff? Did it work/help with new regrowth? What percent did you use? etc

[Jazz1]

See my threads, I use 1.5% in my lotion Hairloss mixture, I believe it works in conjunction with other proven treatments.

[warner8]

See my threads, I use 1.5% in my lotion Hairloss mixture, I believe it works in conjunction with other proven treatments.

Hi Jazz, what else is in your hair treatment arsenal along with the AA

[Jazz1]

Hi Jazz, what else is in your hair treatment arsenal along with the AA

15% minoxidil
0.1% finesteride
1.5% azelaic acid
0.25% progesterone
0.025% tretinoin
0.1% hydrocortisone.

I also just bought another 3 bottles of Acetyl Glitathione, Vitamin E and C mixture to trial on myself .

[Jazz1]

Here's one key factor as to why I want to trial different compounds on myself. I'm fed up not seeing a cure, maybe one day I may stumble across a cure for all of us .

Glutathione enhances fibroblast collagen contraction and protects keratinocytes from apoptosis in hyperglycaemic culture

The reduced glutathione to oxidized glutathione levels appear to influence G6PDH and maybe vice versa.But this shows indirectly(I believe) that glutathione levels ARE lower in mpb scalp.There is another study which says alopecic scalp is lower in glutathione also but doesnt state if they meant mpb specifically.

The second abstract suggests glutathione is an important part of androgen signaling.Maybe we become more androgen sensitive because of lower glutathione levels? But just blocking the androgen receptor may not be enough because perhaps it doesnt reverse the redox status? Sometimes when pathways are shut down too long merely reversing the original offender doesnt restore them to back to baseline levels as a new homeostatic setpoint was determined.

We can increase glutathione levels and G6PDH(an energy enzyme) by l-carnitine and alpha lipoic acid and NAC and aged garlic(because of s-allyl cysteine).

If you think about what the cell is attempting to do,it makes sense.If a cell has a poor antioxidant defense system it better shut down energy pathways like G6PDH or it could lead to cancer.

Glutathione

Biosci Biotechnol Biochem 1999 Dec;63(12):2219-21 Related Articles, Books

Activity of glucose-6-phosphate 1-dehydrogenase in hair follicles with male-pattern alopecia.

Adachi K, Watanabe Y, Inouye K

Research and Development Headquarters, Lion Corporation, Kanagawa, Japan.

[Medline record in process]

Activity of glucose-6-phosphate 1-dehydrogenase (G6PDH) in human hair follicles was measured. A good relationship has been demonstrated between the activity and the ratio of the number of the anagen hairs to that of all the plucked hairs in the frontal-parietal region of the scalp with male-pattern alopecia. As the ratio becomes lower so that the advancing degree of alopecia is higher, the G6PDH activity becomes lower.

PMID: 10664855, UI: 20128240

Purification of androgen receptors in human sebocytes and hair. Sawaya ME.

University of Miami School of Medicine, Department of Dermatology and Cutaneous Surgery, FL 33101.

Human sebaceous glands (SG) and hair follicles (HF) are target structures in the skin for androgen action. They contain steroid enzymes, capable of transforming weak androgens into the target-tissue-active androgens testosterone (T) and dihydrotestosterone (DHT), which bind to the androgen receptor (AR) to regulate cellular transcription. The AR from HF and SG from human scalp tissue has been purified greater than 86,000 times by phenyl-sepharose, DEAE-sephacel, gel filtration chromatography, and ultrafiltration. Sucrose density gradient analysis and non-denaturing gradient polyacrylamide gel electrophoresis (PAGE) and sodium dodecyl sulfate (SDS)-PAGE revealed two molecular species of AR, an active form called monomer, capable of binding DHT with great specificity (4S, m = 62,000 Da, Kd = 0.6 nM, Bmax 8260 fmol/micrograms protein), and the other, an inactive form of the monomer called tetramer (10.8S, m = 252,000 Da, Kd = 2.9 nM). The two species are interconvertible, and after purification each appeared as a single band on SDS-PAGE. The conversion of the monomer to the tetramer AR form is influenced by reduced and oxidized glutathione, and possibly by an endogenous disulfide converting factor (DCF). Furthermore, biochemical events in the androgenic signal transduction sequence were shown to be stimulated by androgens via the AR. These include the total nuclear AR content, chromatin binding of AR complexes, and stimulation of RNA polymerase II, thus influencing gene expression, which is important in understanding regulation of HF growth and SG proliferation.

L-carnitine and DL-alpha-lipoic acid reverse the age-related deficit in glutathione redox state in skeletal muscle and heart tissues. Kumaran S, Savitha S, Anusuya Devi M, Panneerselvam C.

Department of Medical Biochemistry, Dr. AL Mudaliar Post Graduate Institute of Basic Medical Sciences, Uni

[Jazz1]

15% minoxidil
0.1% finesteride
1.5% azelaic acid
0.25% progesterone
0.025% tretinoin
0.1% hydrocortisone.

I also just bought another 3 bottles of Acetyl Glitathione, Vitamin E and C mixture to trial on myself .

Also to add a topical mixture can be compounded, there's plenty of studies stating Azelaic Acid, Vitamin B6 and Zinc to be a potent DHT blocker when applied topically. So maybe a compound lotion with DMI could be a good call, rather than trying azelaic acid alone.

[warner8]

15% minoxidil
0.1% finesteride
1.5% azelaic acid
0.25% progesterone
0.025% tretinoin
0.1% hydrocortisone.

I also just bought another 3 bottles of Acetyl Glitathione, Vitamin E and C mixture to trial on myself .

Hi Jazz, my compounding pharmacist told me that minoxidil precipitates out of the alcohol/proplyene glycol solution at percents greater than 8%? I have seen it myself with a 10% solution that she made for me despite her fair warning ahead of time. how is it possible that a 15% solution can be made?

[Jazz1]

Hi Jazz, my compounding pharmacist told me that minoxidil precipitates out of the alcohol/proplyene glycol solution at percents greater than 8%? I have seen it myself with a 10% solution that she made for me despite her fair warning ahead of time. how is it possible that a 15% solution can be made?

I believe you are referring to liquid form only, the compound pharmacist I use makes me a lotion and higher grades is cream, see below;

Base formula:
Minoxidil (offered in 5%, 12.5%, 15% and 30%.)
AA 5%
RA 0.025%
Finasteride 0.1%
*
NOTES:
Minoxidil is available:
30% CREAM ONLY
12.5% LOTION ONLY
15% CREAM and LOTION ONLY
5% SPRAY LIQUID AND LOTION ONLY
NOTE: IN THE 5% SPRAY IS MINOXIDIL 5%, FINASTERIDE 0.1% AND AA 5%-NO OTHER ADDITIVES!!!!!
WE OFFER A 5% MINOXIDIL FOAM WITH NO ADDITIVES
*
General additives to everything BUT 5% spray liquid and foam are:
Progesterone 0.25%
Hydrocortisone 0.1% (NOT 1%)
BIOTIN 1.3%
DMI
*
Also another update:

MINOXIDIL AND ADDITIVES
The following are basic ingredients that have proven scientific validity in hair loss when applied topically:
 Minoxidil – while the exact mechanism of action is unclear, minoxidil is the gold standard ingredient for treating androgenic alopecia
 Finasteride – a 5-alpha reductase inhibitor, stops the conversion of testosterone to dihydrotestosterone (DHT). *Added topically, finasteride works synergistically with the other ingredients to halt further hair loss and promote thickening and re-growth with lower incidence of systemic side effects than oral use
 Azelaic Acid – a 5-alpha reductase inhibitor, stops the conversion of testosterone to dihydrotestosterone (DHT)
 Retinoic Acid (Tretinoin)– a vitamin A derivative, promotes growth and development of new skin and aids in absorption of other active ingredients
 Progesterone – a hormone naturally occurring in both men and women that acts as a 5-alpha reductase inhibitor
 Hydrocortisone – a corticosteroid that reduces inflammation, can be added if needed to prevent irritation from higher dose minoxidil
 Vitamin E – antioxidant and follicle softener, also increases blood circulation (all our minoxidil creams and lotions contain vitamin E at 0.1%)
 We do not recommend adding grape seed extract to a topical formulation because of concerns with staining and there is no scientific literature to prove efficacy.
***We recommend an oral grape seed extract supplement instead of topical use
*
In addition to our custom minoxidil formulations, we have a combination acetyl-glutathione and biotin liquid for daily use.
*
We are formulating 3 adjunct OTC topicals to be used before applying the Minoxidil:
Acetyl Glutathione with vitamin C and E.
Progesterone 3% leave-in treatment
Acetyl Glutathione 3% with Biotin 1.3%
*
 Biotin – a B vitamin that strengthens the hair from the root to increase hair anchoring and targets DHT to prevent hair loss
 Acetyl-Glutathione – potent anti-inflammatory and antioxidant, stimulates mitochondria, breaks down DHT, and detoxifies environmental xenoestrogens which are commonly found in fragrances, bath and body products, personal care products, and cleaning and laundry products.
*
*
Hair health involves the follicle. *1/3 of hair is in the growing phase, 1/3 is in hair loss phase, and 1/3 is in the process of development to maturity. *The goal is to protect the DNA and prevent free radicals from breaking down the cells in the follicle. *To that end we recommend use of antioxidants, SLS-free shampoo/conditioner (Check out our line of NON-TOXIC STIMULATING shampoos and conditioners on our hair loss page), and avoidance of pesticides/chemicals in food and water, and eating healthfully.
*
*
Oral supplements recommended for management of hair loss:
Murray Avenue Apothecary’s DHT/Hormone Balancer Caps-contains Saw Palmetto (alternative to finasteride) with other DHT balancing ingredients for hair loss and prostate health.
Grape seed extract – a concentrate of flavanoids, linoleic acid, vitamin E and oligomeric proanthocyanidins (OPCs), the last two constituents are known to stop hair loss and promote hair regrowth. *
Other oral supplements include Vitamin E Succinate, Zinc Methionine, , Acetyl Glutathione-exclusive to Murray Avenue Apothecary, Linolenic Acid-Borage oil or Evening Primrose oil, Fish Oil, MAA Easy Absorb Iron -with Iron Bis-Glycinate, Thyroid Support, Vitamin B Complex and Biotin Forte

[warner8]

Do you believe that minox is really dose dependent? As in a 15% minox will achieve better results than a 5% minox?

I believe you are referring to liquid form only, the compound pharmacist I use makes me a lotion and higher grades is cream, see below;

Base formula:
Minoxidil (offered in 5%, 12.5%, 15% and 30%.)
AA 5%
RA 0.025%
Finasteride 0.1%
*
NOTES:
Minoxidil is available:
30% CREAM ONLY
12.5% LOTION ONLY
15% CREAM and LOTION ONLY
5% SPRAY LIQUID AND LOTION ONLY
NOTE: IN THE 5% SPRAY IS MINOXIDIL 5%, FINASTERIDE 0.1% AND AA 5%-NO OTHER ADDITIVES!!!!!
WE OFFER A 5% MINOXIDIL FOAM WITH NO ADDITIVES
*
General additives to everything BUT 5% spray liquid and foam are:
Progesterone 0.25%
Hydrocortisone 0.1% (NOT 1%)
BIOTIN 1.3%
DMI
*
Also another update:

MINOXIDIL AND ADDITIVES
The following are basic ingredients that have proven scientific validity in hair loss when applied topically:
 Minoxidil – while the exact mechanism of action is unclear, minoxidil is the gold standard ingredient for treating androgenic alopecia
 Finasteride – a 5-alpha reductase inhibitor, stops the conversion of testosterone to dihydrotestosterone (DHT). *Added topically, finasteride works synergistically with the other ingredients to halt further hair loss and promote thickening and re-growth with lower incidence of systemic side effects than oral use
 Azelaic Acid – a 5-alpha reductase inhibitor, stops the conversion of testosterone to dihydrotestosterone (DHT)
 Retinoic Acid (Tretinoin)– a vitamin A derivative, promotes growth and development of new skin and aids in absorption of other active ingredients
 Progesterone – a hormone naturally occurring in both men and women that acts as a 5-alpha reductase inhibitor
 Hydrocortisone – a corticosteroid that reduces inflammation, can be added if needed to prevent irritation from higher dose minoxidil
 Vitamin E – antioxidant and follicle softener, also increases blood circulation (all our minoxidil creams and lotions contain vitamin E at 0.1%)
 We do not recommend adding grape seed extract to a topical formulation because of concerns with staining and there is no scientific literature to prove efficacy.
***We recommend an oral grape seed extract supplement instead of topical use
*
In addition to our custom minoxidil formulations, we have a combination acetyl-glutathione and biotin liquid for daily use.
*
We are formulating 3 adjunct OTC topicals to be used before applying the Minoxidil:
Acetyl Glutathione with vitamin C and E.
Progesterone 3% leave-in treatment
Acetyl Glutathione 3% with Biotin 1.3%
*
 Biotin – a B vitamin that strengthens the hair from the root to increase hair anchoring and targets DHT to prevent hair loss
 Acetyl-Glutathione – potent anti-inflammatory and antioxidant, stimulates mitochondria, breaks down DHT, and detoxifies environmental xenoestrogens which are commonly found in fragrances, bath and body products, personal care products, and cleaning and laundry products.
*
*
Hair health involves the follicle. *1/3 of hair is in the growing phase, 1/3 is in hair loss phase, and 1/3 is in the process of development to maturity. *The goal is to protect the DNA and prevent free radicals from breaking down the cells in the follicle. *To that end we recommend use of antioxidants, SLS-free shampoo/conditioner (Check out our line of NON-TOXIC STIMULATING shampoos and conditioners on our hair loss page), and avoidance of pesticides/chemicals in food and water, and eating healthfully.
*
*
Oral supplements recommended for management of hair loss:
Murray Avenue Apothecary’s DHT/Hormone Balancer Caps-contains Saw Palmetto (alternative to finasteride) with other DHT balancing ingredients for hair loss and prostate health.
Grape seed extract – a concentrate of flavanoids, linoleic acid, vitamin E and oligomeric proanthocyanidins (OPCs), the last two constituents are known to stop hair loss and promote hair regrowth. *
Other oral supplements include Vitamin E Succinate, Zinc Methionine, , Acetyl Glutathione-exclusive to Murray Avenue Apothecary, Linolenic Acid-Borage oil or Evening Primrose oil, Fish Oil, MAA Easy Absorb Iron -with Iron Bis-Glycinate, Thyroid Support, Vitamin B Complex and Biotin Forte

[Jazz1]

Yes 100% as when I upped the Dosage I achieved better results, there's plenty of proof IE The Belgravia Center in the uk well documented pictures and Dr Richard Lee.