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Originally Posted by Thinning87
I have to say I am kind of optimistic about Replicel though, in terms of product. So far we have only seen results at less than the 2 year timeline needed for a hair follicle to grow hair. Sheiseido's investment is a good sign, if it is true that they have been shown these results as Spencer suggested in a podcast a while ago I believe.
Now, that doesn't necessarily mean it is it, but we might have a positive surprise.
As to timelines, all we can do is hope the Japanese researchers can count on more resources to get to market with this thing if it turns out to be as good as I think it will be.
If you haven't read the posts of Dr. Aaron Gardener on this forum regarding the multiplication of DP or DSC cells it is illuminating. The major issue as I understand it is culturing these cells into the millions over numerous passes without losing their inductive characteristics. I believe Dr. Gardener's group has been successful in restoring up to 60% of the characteristics of DP cells using 3D cultering. However, they had no success in restoring the characteristics of DS cells. Here is a quote from one of his posts:
"So I'll summarise our workings on the DS:
• Freshly isolated DS is as competent as the DP.
• The DS acts as a reservoir for DP cells during the morphological changes of the hair cycle, see:
http://www.akclinics.com/images/regrowth-cycle.jpg
• In our hands 2D expanded DS do not retain inductivity.
• In our hands 3D culture of DS does not restore inductivity.
• We are attempting to restore inductivity in the DS by increasing expression of DP specific genes in the DS, but have currently not had any success.
• This is designed to help us identify key genes so that we can hopefully in the future use dermal fibroblasts, a much easier to isolated and expand population than DS or DP. See the Rendl labs work, they are attempting to go direct from DF already, very exciting work.
As for Replicel I honestly don't know as I've not seen any data. I know they reported the findings of their clinical trial in Japan but I've not seen the data myself. I would imagine they have the same issues as other and other groups, but, they may be doing something different that has allowed them to get past this. Again, it will be very interesting to see the findings and I think it's a very valid approach as a whole but I don't know the specifics."
Does anyone know what happened with Dr. Gardener? His posts on this forum just stopped cold.
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