Results 1 to 10 of 36

Threaded View

  1. #19
    Senior Member
    Join Date
    May 2010
    Posts
    188

    Default

    Quote Originally Posted by Thinning87 View Post
    I have to say I am kind of optimistic about Replicel though, in terms of product. So far we have only seen results at less than the 2 year timeline needed for a hair follicle to grow hair. Sheiseido's investment is a good sign, if it is true that they have been shown these results as Spencer suggested in a podcast a while ago I believe.

    Now, that doesn't necessarily mean it is it, but we might have a positive surprise.

    As to timelines, all we can do is hope the Japanese researchers can count on more resources to get to market with this thing if it turns out to be as good as I think it will be.
    If you haven't read the posts of Dr. Aaron Gardener on this forum regarding the multiplication of DP or DSC cells it is illuminating. The major issue as I understand it is culturing these cells into the millions over numerous passes without losing their inductive characteristics. I believe Dr. Gardener's group has been successful in restoring up to 60% of the characteristics of DP cells using 3D cultering. However, they had no success in restoring the characteristics of DS cells. Here is a quote from one of his posts:

    "So I'll summarise our workings on the DS:

    • Freshly isolated DS is as competent as the DP.
    • The DS acts as a reservoir for DP cells during the morphological changes of the hair cycle, see:
    http://www.akclinics.com/images/regrowth-cycle.jpg
    • In our hands 2D expanded DS do not retain inductivity.
    • In our hands 3D culture of DS does not restore inductivity.
    • We are attempting to restore inductivity in the DS by increasing expression of DP specific genes in the DS, but have currently not had any success.
    • This is designed to help us identify key genes so that we can hopefully in the future use dermal fibroblasts, a much easier to isolated and expand population than DS or DP. See the Rendl labs work, they are attempting to go direct from DF already, very exciting work.

    As for Replicel I honestly don't know as I've not seen any data. I know they reported the findings of their clinical trial in Japan but I've not seen the data myself. I would imagine they have the same issues as other and other groups, but, they may be doing something different that has allowed them to get past this. Again, it will be very interesting to see the findings and I think it's a very valid approach as a whole but I don't know the specifics."

    Does anyone know what happened with Dr. Gardener? His posts on this forum just stopped cold.

Similar Threads

  1. Histogen and Replicel : stem cell meeting on the Mesa
    By noisette in forum Cutting Edge / Future Treatments
    Replies: 102
    Last Post: 12-08-2014, 01:04 AM
  2. Japanese scientists generate human organ from stem cells (First time ever!)
    By Westonci in forum Cutting Edge / Future Treatments
    Replies: 20
    Last Post: 07-04-2013, 05:33 PM
  3. I finally have some negative side effects to report
    By PatientlyWaiting in forum Men's Hair Loss: Start Your Own Topic
    Replies: 9
    Last Post: 05-30-2013, 12:56 PM
  4. 10/2011 Study: <1.0% Japanese Men Show Side Effects on Finasteride
    By HairTalk in forum Hair Loss Treatments
    Replies: 22
    Last Post: 01-23-2012, 04:59 PM
  5. Replies: 3
    Last Post: 03-31-2010, 05:37 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts

» IAHRS

hair transplant surgeons

» The Bald Truth

» Recent Threads

1800 graft repair case results by Dr. Lindsey
Yesterday 08:38 AM
Last Post By Dr. Lindsey
Yesterday 08:38 AM
Navigating the German Job Market as a Kenyan Citizen
11-04-2023 06:31 AM
Last Post By Keegan212
Yesterday 03:51 AM
DR HAKAN DOGANAY/ 4500 GRAFTS / Implanter Pen+FUE
03-26-2024 04:15 PM
Last Post By Hakan Doganay, MD
03-26-2024 04:15 PM
The Mane Event for Thursday, June 15th, 2023
06-15-2023 02:59 PM
Last Post By gisecit34
03-26-2024 08:05 AM