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http://www.ncbi.nlm.nih.gov/pubmed/8655609 in this study is was actually the worst to add IGF1. Binding proteins were at the highest level.
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The study WAS PUBLISHED on 1996...lol
And there are so many years nd so many studies about IGF1. Like Hellouser said well, this doesn't mean a thing until results are made public !
You said HISTOGEN have no great results ! lol I'm not agree with you. For you perhaps, but for me this is a better treatment than fina and minox !Comment
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ANd are you sure you have seen this video ?? LOOK WELL on the results (Total hair count = +51,28% from a baseline to one year and TERMINAL HAIR COUNT = +123,36% )
These are not great results ??
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i even think histogen could have much better results with follicepts vehicle.
instead of using not always effective injections at higher doses, it's better to work with follicepts vehicle on a daily basis, with much lower concentration. lower but regular doses would also eliminate safety risks and side-effects of histogen enormously.
the more i think about it, the more i have the feeling follicept should reach out and team up with histogen, unless histogen completely dissapears from the market. because, with their current injections and relatively unspectacular results histogen will never come to market. they can't even get funding. a better topical vehicle and turning histogen in a treatment which could be used at home would be a gamechanger, instead of flying over to an asian country every 3 months or so.
Devon should give this idea a thought... and maybe (if IGF1 alone doesn't pan out) get in talks with histogen.Comment
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You obviously did not follow all the histogen threads and pictures. You can research it yourself and see its not as good as they lead on, which wasn't that good in the first place. Somehow a study from 1996 is invalid but rat studies on rats with no MPB is first class? Lol.ANd are you sure you have seen this video ?? LOOK WELL on the results (Total hair count = +51,28% from a baseline to one year and TERMINAL HAIR COUNT = +123,36% )
These are not great results ??
www.youtube.com/watch?v=WIM-vA6l0u8#t=219Comment
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And by the way.. The studies from post #10 are meaningless. None of them showed IGF1 increasing hair counts. All but one of them are about VEGF which has nothing to do with IGF1.Comment
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The study that you have posted is talking about HIGH level of IGF1. Doesn't mean anything for IGF1 at normal level, like the other studies, more recents, and Follicept.
Histogen isn't a cure but for me it's a better option than Fina + Minox. If you say not, i don't care.Comment
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Wrong. Read the study again. It's showing how dermal papillas will produce binding proteins to minimize the localized IGF-1. It shows this happening with retinoids, steroids, and direct IGF-1 action. It does not say what concentration IGF-1 was cultured so your comment is invalid.Comment
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And ?Comment
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I read again your study. And I will explain you why I tell you "high level" because you don't understand well your Own post with the Study.
" The IGFBP-3, in turn, forms a complex with free IGF1 to reduce the concentration of IGF1 available to stimulate hair elongation and maintenance of anagen phase ". (Conclusion from your study)
So " The free Igf1 stimulates the proliferation of keratinocytes (skin cells below the scalp). As the keratinocytes mature, they migrate to the top of the scalp and become what is known as corneocytes. If all goes well, the corneocytes are supposed to be shed off the scalp in a process called apoptosis. The shedding of corneocytes or the apoptosis of corneocytes, is under the influence of IGFBP-3 (insulin-like-growth-factor-binding-protein-3) and endogenous retinoids ". In men with male-pattern-baldness, they have excess free-IGF-1 and not enough IGFBP-3 .
IF YOU SEE AN ANOTHER STUDY TO UNDESTAND YOUR OWN POST :
"Those with vertex balding had high IGF-1 levels and low circulating levels of IGFBP-3 "
Source: http://www.ncbi.nlm.nih.gov/pubmed/10827403
On your study, the author tells that " However, little is known about IGF1 signaling in the hair follicle. " So he didn't know well the IGF1 signaling, in 1996.
"The IGFBP-3, in turn, forms a complex with free IGF1 to reduce the concentration of IGF1 available " (from your study)
So, If we can increase IGF1 directly into the Dermal papilla, we can "stimulate hair elongation and maintenance of anagen phase". And Not increasing IGF1 on our blood.
If we can increase IGF1 directly into the follicle, so IGF1 is enough to stimulate hair elongation and maintenance of anagen phase. You study prove that ! Follicept is for me a possible treatment.Comment
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Who cares about IGF-1? It's not going to work anyway, aside from unicorn land.Comment
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